Clinicopathologic analysis of multiple (Five or More) atypical adenomatous hyperplasias (AAHs) of the lung: Evidence for the AAH-adenocarcinoma sequence

Akiko Miyagi Maeshima, Naobumi Tochigi, Akihiko Yoshida, Hisao Asamura, Koji Tsuta, Hitoshi Tsuda

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

OBJECTIVE:: Clarification of the clinicopathologic characteristics of patients with multiple atypical adenomatous hyperplasias (AAHs). MATERIALS AND METHODS:: The subjects were 1639 patients who underwent lobectomy or pneumonectomy for lung tumors. The clinicopathologic features of the AAHs in the lung background and the main tumors were examined with regard to the number and the size of the AAHs, the incidence and histology of adenocarcinomas (ADs), and the outcome. RESULTS:: Thirty-two patients (2.0%) had 5 or more AAHs (ranging from 5 to 171), being present predominantly in the upper lobe (86%) and in women (75%). Among the 794 AAHs, 495 (62%) measured less than 1 mm, 170 (22%) measured 1 to less than 2 mm, 118 (15%) measured 2 to less than 5 mm, and 11 (1%) measured 5 to less than 10 mm. Twenty-eight patients (88%) had AD (1 in 18 patients and 2 to 6 in 10 patients). Thirty-two of the 51 patients with ADs (63%) had an AAH component. The incidence of ADs among the total of both AAHs and ADs was 6.0% (51 of 845). The 5-year cancer-free survival rate was 71.4%. CONCLUSION:: Five or more AAHs were seen in the background in 2.0% of lung tumors. Most of the AAHs were small, measuring less than 2 mm, and few exceeded 5 mm. Most of the patients had ADs, which were histologically suggested to be derived from AAH. However, the incidence of the AAH-AD sequence was considered to be low at the tumor basis, and the outcome of ADs was not very favorable.

Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalJournal of Thoracic Oncology
Volume5
Issue number4
DOIs
Publication statusPublished - 2010 Apr
Externally publishedYes

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Hyperplasia
Adenocarcinoma
Lung
Neoplasms
Incidence
Pneumonectomy
Histology
Survival Rate

Keywords

  • Adenocarcinoma
  • Atypical adenomatous hyperplasia
  • Lung
  • Multiple
  • Prognosis
  • Sequence

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Clinicopathologic analysis of multiple (Five or More) atypical adenomatous hyperplasias (AAHs) of the lung : Evidence for the AAH-adenocarcinoma sequence. / Maeshima, Akiko Miyagi; Tochigi, Naobumi; Yoshida, Akihiko; Asamura, Hisao; Tsuta, Koji; Tsuda, Hitoshi.

In: Journal of Thoracic Oncology, Vol. 5, No. 4, 04.2010, p. 466-471.

Research output: Contribution to journalArticle

Maeshima, Akiko Miyagi ; Tochigi, Naobumi ; Yoshida, Akihiko ; Asamura, Hisao ; Tsuta, Koji ; Tsuda, Hitoshi. / Clinicopathologic analysis of multiple (Five or More) atypical adenomatous hyperplasias (AAHs) of the lung : Evidence for the AAH-adenocarcinoma sequence. In: Journal of Thoracic Oncology. 2010 ; Vol. 5, No. 4. pp. 466-471.
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abstract = "OBJECTIVE:: Clarification of the clinicopathologic characteristics of patients with multiple atypical adenomatous hyperplasias (AAHs). MATERIALS AND METHODS:: The subjects were 1639 patients who underwent lobectomy or pneumonectomy for lung tumors. The clinicopathologic features of the AAHs in the lung background and the main tumors were examined with regard to the number and the size of the AAHs, the incidence and histology of adenocarcinomas (ADs), and the outcome. RESULTS:: Thirty-two patients (2.0{\%}) had 5 or more AAHs (ranging from 5 to 171), being present predominantly in the upper lobe (86{\%}) and in women (75{\%}). Among the 794 AAHs, 495 (62{\%}) measured less than 1 mm, 170 (22{\%}) measured 1 to less than 2 mm, 118 (15{\%}) measured 2 to less than 5 mm, and 11 (1{\%}) measured 5 to less than 10 mm. Twenty-eight patients (88{\%}) had AD (1 in 18 patients and 2 to 6 in 10 patients). Thirty-two of the 51 patients with ADs (63{\%}) had an AAH component. The incidence of ADs among the total of both AAHs and ADs was 6.0{\%} (51 of 845). The 5-year cancer-free survival rate was 71.4{\%}. CONCLUSION:: Five or more AAHs were seen in the background in 2.0{\%} of lung tumors. Most of the AAHs were small, measuring less than 2 mm, and few exceeded 5 mm. Most of the patients had ADs, which were histologically suggested to be derived from AAH. However, the incidence of the AAH-AD sequence was considered to be low at the tumor basis, and the outcome of ADs was not very favorable.",
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AU - Maeshima, Akiko Miyagi

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AU - Yoshida, Akihiko

AU - Asamura, Hisao

AU - Tsuta, Koji

AU - Tsuda, Hitoshi

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N2 - OBJECTIVE:: Clarification of the clinicopathologic characteristics of patients with multiple atypical adenomatous hyperplasias (AAHs). MATERIALS AND METHODS:: The subjects were 1639 patients who underwent lobectomy or pneumonectomy for lung tumors. The clinicopathologic features of the AAHs in the lung background and the main tumors were examined with regard to the number and the size of the AAHs, the incidence and histology of adenocarcinomas (ADs), and the outcome. RESULTS:: Thirty-two patients (2.0%) had 5 or more AAHs (ranging from 5 to 171), being present predominantly in the upper lobe (86%) and in women (75%). Among the 794 AAHs, 495 (62%) measured less than 1 mm, 170 (22%) measured 1 to less than 2 mm, 118 (15%) measured 2 to less than 5 mm, and 11 (1%) measured 5 to less than 10 mm. Twenty-eight patients (88%) had AD (1 in 18 patients and 2 to 6 in 10 patients). Thirty-two of the 51 patients with ADs (63%) had an AAH component. The incidence of ADs among the total of both AAHs and ADs was 6.0% (51 of 845). The 5-year cancer-free survival rate was 71.4%. CONCLUSION:: Five or more AAHs were seen in the background in 2.0% of lung tumors. Most of the AAHs were small, measuring less than 2 mm, and few exceeded 5 mm. Most of the patients had ADs, which were histologically suggested to be derived from AAH. However, the incidence of the AAH-AD sequence was considered to be low at the tumor basis, and the outcome of ADs was not very favorable.

AB - OBJECTIVE:: Clarification of the clinicopathologic characteristics of patients with multiple atypical adenomatous hyperplasias (AAHs). MATERIALS AND METHODS:: The subjects were 1639 patients who underwent lobectomy or pneumonectomy for lung tumors. The clinicopathologic features of the AAHs in the lung background and the main tumors were examined with regard to the number and the size of the AAHs, the incidence and histology of adenocarcinomas (ADs), and the outcome. RESULTS:: Thirty-two patients (2.0%) had 5 or more AAHs (ranging from 5 to 171), being present predominantly in the upper lobe (86%) and in women (75%). Among the 794 AAHs, 495 (62%) measured less than 1 mm, 170 (22%) measured 1 to less than 2 mm, 118 (15%) measured 2 to less than 5 mm, and 11 (1%) measured 5 to less than 10 mm. Twenty-eight patients (88%) had AD (1 in 18 patients and 2 to 6 in 10 patients). Thirty-two of the 51 patients with ADs (63%) had an AAH component. The incidence of ADs among the total of both AAHs and ADs was 6.0% (51 of 845). The 5-year cancer-free survival rate was 71.4%. CONCLUSION:: Five or more AAHs were seen in the background in 2.0% of lung tumors. Most of the AAHs were small, measuring less than 2 mm, and few exceeded 5 mm. Most of the patients had ADs, which were histologically suggested to be derived from AAH. However, the incidence of the AAH-AD sequence was considered to be low at the tumor basis, and the outcome of ADs was not very favorable.

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KW - Prognosis

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