Abstract
Purpose: To investigate the clinical features and pathologic diagnosis of prenatally diagnosed lung diseases. Materials and Methods: The medical records of 28 fetuses with prenatally diagnosed lung diseases were reviewed with regard to perinatal courses, ultrasonographic measurement of the lesion volume ratio, and the histopathology of lung tissue. Results: Of the 23 fetuses with a prenatal diagnosis of congenital cystic adenomatoid malformation (CCAM), 4 required an emergency lobectomy (1 prenatally and 3 postnatally), whereas the other 14 showed uneventful courses after birth. The pathologic diagnosis of the resected lungs included CCAM (n = 4), lobar emphysema (n = 2), intralobar sequestration (n = 2), and bronchial atresia (n = 1). The peak value of the lesion volume ratio was significantly higher in the CCAM cases that required urgent surgery than in the non-CCAM cases (2.29 ± 0.46 vs 1.20 ± 0.21, P < .001). The ratio decreased after the 25th to the 30th week to less than 1.0 in the 5 non-CCAM cases, but remained higher than 2.0 in the 4 CCAM cases. Prenatally diagnosed extralobar pulmonary sequestration caused massive pleural effusion requiring a fetal intervention in 4 of the 5 fetuses. Conclusions: The prenatally diagnosed lung lesions include various kinds of pulmonary diseases. Regardless of the diseases, sequential ultrasonographic assessment may predict perinatal risks.
| Original language | English |
|---|---|
| Pages (from-to) | 2028-2031 |
| Number of pages | 4 |
| Journal | Journal of Pediatric Surgery |
| Volume | 41 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2006 Dec |
| Externally published | Yes |
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Keywords
- CCAM
- Lung diseases
- Prenatal diagnosis
- Pulmonary sequestration
ASJC Scopus subject areas
- Surgery
Cite this
Clinicopathologic assessment of prenatally diagnosed lung diseases. / Kuroda, Tatsuo; Morikawa, Nobuyuki; Kitano, Yoshihiro; Sago, Haruhiko; Hayashi, Satoshi; Honna, Toshiro; Saeki, Morihiro.
In: Journal of Pediatric Surgery, Vol. 41, No. 12, 12.2006, p. 2028-2031.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinicopathologic assessment of prenatally diagnosed lung diseases
AU - Kuroda, Tatsuo
AU - Morikawa, Nobuyuki
AU - Kitano, Yoshihiro
AU - Sago, Haruhiko
AU - Hayashi, Satoshi
AU - Honna, Toshiro
AU - Saeki, Morihiro
PY - 2006/12
Y1 - 2006/12
N2 - Purpose: To investigate the clinical features and pathologic diagnosis of prenatally diagnosed lung diseases. Materials and Methods: The medical records of 28 fetuses with prenatally diagnosed lung diseases were reviewed with regard to perinatal courses, ultrasonographic measurement of the lesion volume ratio, and the histopathology of lung tissue. Results: Of the 23 fetuses with a prenatal diagnosis of congenital cystic adenomatoid malformation (CCAM), 4 required an emergency lobectomy (1 prenatally and 3 postnatally), whereas the other 14 showed uneventful courses after birth. The pathologic diagnosis of the resected lungs included CCAM (n = 4), lobar emphysema (n = 2), intralobar sequestration (n = 2), and bronchial atresia (n = 1). The peak value of the lesion volume ratio was significantly higher in the CCAM cases that required urgent surgery than in the non-CCAM cases (2.29 ± 0.46 vs 1.20 ± 0.21, P < .001). The ratio decreased after the 25th to the 30th week to less than 1.0 in the 5 non-CCAM cases, but remained higher than 2.0 in the 4 CCAM cases. Prenatally diagnosed extralobar pulmonary sequestration caused massive pleural effusion requiring a fetal intervention in 4 of the 5 fetuses. Conclusions: The prenatally diagnosed lung lesions include various kinds of pulmonary diseases. Regardless of the diseases, sequential ultrasonographic assessment may predict perinatal risks.
AB - Purpose: To investigate the clinical features and pathologic diagnosis of prenatally diagnosed lung diseases. Materials and Methods: The medical records of 28 fetuses with prenatally diagnosed lung diseases were reviewed with regard to perinatal courses, ultrasonographic measurement of the lesion volume ratio, and the histopathology of lung tissue. Results: Of the 23 fetuses with a prenatal diagnosis of congenital cystic adenomatoid malformation (CCAM), 4 required an emergency lobectomy (1 prenatally and 3 postnatally), whereas the other 14 showed uneventful courses after birth. The pathologic diagnosis of the resected lungs included CCAM (n = 4), lobar emphysema (n = 2), intralobar sequestration (n = 2), and bronchial atresia (n = 1). The peak value of the lesion volume ratio was significantly higher in the CCAM cases that required urgent surgery than in the non-CCAM cases (2.29 ± 0.46 vs 1.20 ± 0.21, P < .001). The ratio decreased after the 25th to the 30th week to less than 1.0 in the 5 non-CCAM cases, but remained higher than 2.0 in the 4 CCAM cases. Prenatally diagnosed extralobar pulmonary sequestration caused massive pleural effusion requiring a fetal intervention in 4 of the 5 fetuses. Conclusions: The prenatally diagnosed lung lesions include various kinds of pulmonary diseases. Regardless of the diseases, sequential ultrasonographic assessment may predict perinatal risks.
KW - CCAM
KW - Lung diseases
KW - Prenatal diagnosis
KW - Pulmonary sequestration
UR - http://www.scopus.com/inward/record.url?scp=33845226198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845226198&partnerID=8YFLogxK
U2 - 10.1016/j.jpedsurg.2006.08.001
DO - 10.1016/j.jpedsurg.2006.08.001
M3 - Article
C2 - 17161198
AN - SCOPUS:33845226198
VL - 41
SP - 2028
EP - 2031
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
SN - 0022-3468
IS - 12
ER -