Clinicopathologic features of small pancreatic adenocarcinoma

A collective study

Hiroyoshi Furukawa, Shuichi Okada, Hiromitsu Saisho, Jo Ariyama, Eii Karasawa, Akihiko Nakaizumi, Saburo Nakazawa, Kouji Murakami, Tadao Kakizoe

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

BACKGROUND. Early diagnosis and complete removal of pancreatic adenocarcinoma (PC) is essential to improve its poor prognosis. It is necessary to find PC when it is small and at an early stage if surgical is to be successful. This is an investigation of the clinicopathologic features of small PC. METHODS. Thirty-one resected and histophatologically examined cases of small PC, 2cm or less in greatest dimension, were collected from 7 institutions between 1989 and 1994, and their clinicopathologic features were analyzed in detail. RESULTS. Eighteen patients (58.1%) had some symptoms or signs at the time of diagnosis, however, the other 13 (41.9%) had no symptoms. There was no sensitive blood test for the detection of small PC. The detection rates of the pancreatic tumor mass on ultrasonography, endoscopic ultrasonography, and computed tomography were 64.5% (20/31), 73.7% (14/19), and 64.5% (20/31), respectively. Only 13 patients (41.9%) were in International Union Against Cancer (UICC) Stage 1 and the other 18 were III IV to lymph node metastasis or peritoneal dissemination. The overall 4-year postoperative survival rate was 54.5% and that of patients in Stage I was 77.9%. CONCLUSION. To detect a small PC, a thorough examination may be required in patients with slightly abnormal findings on laboratory tests or imaging modalities, even if the patient is asymptomatic. PC 2 cm or less and belonging to Stage I may be regarded as an early carcinoma, because of its good prognosis.

Original languageEnglish
Pages (from-to)986-990
Number of pages5
JournalCancer
Volume78
Issue number5
DOIs
Publication statusPublished - 1996 Sep 1
Externally publishedYes

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Adenocarcinoma
Endosonography
Hematologic Tests
Signs and Symptoms
Early Diagnosis
Ultrasonography
Survival Rate
Lymph Nodes
Tomography
Neoplasm Metastasis
Carcinoma
Neoplasms

Keywords

  • diagnosis
  • pancreatic adenocarcinoma
  • pathology
  • prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Furukawa, H., Okada, S., Saisho, H., Ariyama, J., Karasawa, E., Nakaizumi, A., ... Kakizoe, T. (1996). Clinicopathologic features of small pancreatic adenocarcinoma: A collective study. Cancer, 78(5), 986-990. https://doi.org/10.1002/(SICI)1097-0142(19960901)78:5<986::AID-CNCR7>3.0.CO;2-A

Clinicopathologic features of small pancreatic adenocarcinoma : A collective study. / Furukawa, Hiroyoshi; Okada, Shuichi; Saisho, Hiromitsu; Ariyama, Jo; Karasawa, Eii; Nakaizumi, Akihiko; Nakazawa, Saburo; Murakami, Kouji; Kakizoe, Tadao.

In: Cancer, Vol. 78, No. 5, 01.09.1996, p. 986-990.

Research output: Contribution to journalArticle

Furukawa, H, Okada, S, Saisho, H, Ariyama, J, Karasawa, E, Nakaizumi, A, Nakazawa, S, Murakami, K & Kakizoe, T 1996, 'Clinicopathologic features of small pancreatic adenocarcinoma: A collective study', Cancer, vol. 78, no. 5, pp. 986-990. https://doi.org/10.1002/(SICI)1097-0142(19960901)78:5<986::AID-CNCR7>3.0.CO;2-A
Furukawa, Hiroyoshi ; Okada, Shuichi ; Saisho, Hiromitsu ; Ariyama, Jo ; Karasawa, Eii ; Nakaizumi, Akihiko ; Nakazawa, Saburo ; Murakami, Kouji ; Kakizoe, Tadao. / Clinicopathologic features of small pancreatic adenocarcinoma : A collective study. In: Cancer. 1996 ; Vol. 78, No. 5. pp. 986-990.
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AU - Nakaizumi, Akihiko

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N2 - BACKGROUND. Early diagnosis and complete removal of pancreatic adenocarcinoma (PC) is essential to improve its poor prognosis. It is necessary to find PC when it is small and at an early stage if surgical is to be successful. This is an investigation of the clinicopathologic features of small PC. METHODS. Thirty-one resected and histophatologically examined cases of small PC, 2cm or less in greatest dimension, were collected from 7 institutions between 1989 and 1994, and their clinicopathologic features were analyzed in detail. RESULTS. Eighteen patients (58.1%) had some symptoms or signs at the time of diagnosis, however, the other 13 (41.9%) had no symptoms. There was no sensitive blood test for the detection of small PC. The detection rates of the pancreatic tumor mass on ultrasonography, endoscopic ultrasonography, and computed tomography were 64.5% (20/31), 73.7% (14/19), and 64.5% (20/31), respectively. Only 13 patients (41.9%) were in International Union Against Cancer (UICC) Stage 1 and the other 18 were III IV to lymph node metastasis or peritoneal dissemination. The overall 4-year postoperative survival rate was 54.5% and that of patients in Stage I was 77.9%. CONCLUSION. To detect a small PC, a thorough examination may be required in patients with slightly abnormal findings on laboratory tests or imaging modalities, even if the patient is asymptomatic. PC 2 cm or less and belonging to Stage I may be regarded as an early carcinoma, because of its good prognosis.

AB - BACKGROUND. Early diagnosis and complete removal of pancreatic adenocarcinoma (PC) is essential to improve its poor prognosis. It is necessary to find PC when it is small and at an early stage if surgical is to be successful. This is an investigation of the clinicopathologic features of small PC. METHODS. Thirty-one resected and histophatologically examined cases of small PC, 2cm or less in greatest dimension, were collected from 7 institutions between 1989 and 1994, and their clinicopathologic features were analyzed in detail. RESULTS. Eighteen patients (58.1%) had some symptoms or signs at the time of diagnosis, however, the other 13 (41.9%) had no symptoms. There was no sensitive blood test for the detection of small PC. The detection rates of the pancreatic tumor mass on ultrasonography, endoscopic ultrasonography, and computed tomography were 64.5% (20/31), 73.7% (14/19), and 64.5% (20/31), respectively. Only 13 patients (41.9%) were in International Union Against Cancer (UICC) Stage 1 and the other 18 were III IV to lymph node metastasis or peritoneal dissemination. The overall 4-year postoperative survival rate was 54.5% and that of patients in Stage I was 77.9%. CONCLUSION. To detect a small PC, a thorough examination may be required in patients with slightly abnormal findings on laboratory tests or imaging modalities, even if the patient is asymptomatic. PC 2 cm or less and belonging to Stage I may be regarded as an early carcinoma, because of its good prognosis.

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