Clinicopathologic manifestations of early-onset endometrial cancer in Japanese women with a familial predisposition to cancer

Wataru Yamagami, Nobuyuki Susumu, Kouji Banno, Takeshi Hirao, Fumio Kataoka, Akira Hirasawa, Nao Suzuki, Daisuke Aoki, Shiro Nozawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: The number of patients under 40 years of age with early-onset endometrial cancer is on the rise in Japan. Preservation of fertility in younger patients is a critical issue. In order to examine the clinical and pathological characteristics of these patients, cases of early-onset endometrial cancer at a single hospital were analyzed. Methods: Seventy-four patients were diagnosed with endometrial cancer before age 40 and included in this study after obtaining informed consent. Results: The clinical characteristics included a significantly higher prevalence of complications such as nulligravidity and nulliparity (P < 0.001). Pathologically, well-differentiated endometrial carcinoma was significantly more frequent (P = 0.011). The 5-year survival rate was high (98.7%). In regards to the relationship between clinicopathological features and grade of differentiation, the prevalence of G2 and G3 carcinoma was not significantly lower (P = 0.24) in patients with obesity. Although the frequency of G2 and G3 carcinoma was significantly higher in patients with a family history of cancer (P = 0.02), their 5-year survival rate was not significantly lower (100%). Conclusion: This study found that these two types of early-onset endometrial cancer are clinicopathologically different. In patients with a family history of cancer, their body mass index was lower, and the frequency of G2 and G3 carcinoma was significantly higher, but their 5-year disease-free survival rate was not significantly lower.

Original languageEnglish
Pages (from-to)444-451
Number of pages8
JournalJournal of Obstetrics and Gynaecology Research
Volume31
Issue number5
DOIs
Publication statusPublished - 2005 Oct

Fingerprint

Endometrial Neoplasms
Neoplasms
Survival Rate
Carcinoma
Fertility Preservation
Gravidity
Parity
Informed Consent
Disease-Free Survival
Japan
Body Mass Index
Obesity

Keywords

  • Endometrial cancer
  • Family history of cancer
  • HNPCC
  • Obesity

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Clinicopathologic manifestations of early-onset endometrial cancer in Japanese women with a familial predisposition to cancer. / Yamagami, Wataru; Susumu, Nobuyuki; Banno, Kouji; Hirao, Takeshi; Kataoka, Fumio; Hirasawa, Akira; Suzuki, Nao; Aoki, Daisuke; Nozawa, Shiro.

In: Journal of Obstetrics and Gynaecology Research, Vol. 31, No. 5, 10.2005, p. 444-451.

Research output: Contribution to journalArticle

@article{28280a710d0b44d38767444614da2e11,
title = "Clinicopathologic manifestations of early-onset endometrial cancer in Japanese women with a familial predisposition to cancer",
abstract = "Aim: The number of patients under 40 years of age with early-onset endometrial cancer is on the rise in Japan. Preservation of fertility in younger patients is a critical issue. In order to examine the clinical and pathological characteristics of these patients, cases of early-onset endometrial cancer at a single hospital were analyzed. Methods: Seventy-four patients were diagnosed with endometrial cancer before age 40 and included in this study after obtaining informed consent. Results: The clinical characteristics included a significantly higher prevalence of complications such as nulligravidity and nulliparity (P < 0.001). Pathologically, well-differentiated endometrial carcinoma was significantly more frequent (P = 0.011). The 5-year survival rate was high (98.7{\%}). In regards to the relationship between clinicopathological features and grade of differentiation, the prevalence of G2 and G3 carcinoma was not significantly lower (P = 0.24) in patients with obesity. Although the frequency of G2 and G3 carcinoma was significantly higher in patients with a family history of cancer (P = 0.02), their 5-year survival rate was not significantly lower (100{\%}). Conclusion: This study found that these two types of early-onset endometrial cancer are clinicopathologically different. In patients with a family history of cancer, their body mass index was lower, and the frequency of G2 and G3 carcinoma was significantly higher, but their 5-year disease-free survival rate was not significantly lower.",
keywords = "Endometrial cancer, Family history of cancer, HNPCC, Obesity",
author = "Wataru Yamagami and Nobuyuki Susumu and Kouji Banno and Takeshi Hirao and Fumio Kataoka and Akira Hirasawa and Nao Suzuki and Daisuke Aoki and Shiro Nozawa",
year = "2005",
month = "10",
doi = "10.1111/j.1447-0756.2005.00318.x",
language = "English",
volume = "31",
pages = "444--451",
journal = "Asia-Oceania Journal of Obstetrics and Gynaecology",
issn = "1341-8076",
publisher = "Blackwell Publishing Asia",
number = "5",

}

TY - JOUR

T1 - Clinicopathologic manifestations of early-onset endometrial cancer in Japanese women with a familial predisposition to cancer

AU - Yamagami, Wataru

AU - Susumu, Nobuyuki

AU - Banno, Kouji

AU - Hirao, Takeshi

AU - Kataoka, Fumio

AU - Hirasawa, Akira

AU - Suzuki, Nao

AU - Aoki, Daisuke

AU - Nozawa, Shiro

PY - 2005/10

Y1 - 2005/10

N2 - Aim: The number of patients under 40 years of age with early-onset endometrial cancer is on the rise in Japan. Preservation of fertility in younger patients is a critical issue. In order to examine the clinical and pathological characteristics of these patients, cases of early-onset endometrial cancer at a single hospital were analyzed. Methods: Seventy-four patients were diagnosed with endometrial cancer before age 40 and included in this study after obtaining informed consent. Results: The clinical characteristics included a significantly higher prevalence of complications such as nulligravidity and nulliparity (P < 0.001). Pathologically, well-differentiated endometrial carcinoma was significantly more frequent (P = 0.011). The 5-year survival rate was high (98.7%). In regards to the relationship between clinicopathological features and grade of differentiation, the prevalence of G2 and G3 carcinoma was not significantly lower (P = 0.24) in patients with obesity. Although the frequency of G2 and G3 carcinoma was significantly higher in patients with a family history of cancer (P = 0.02), their 5-year survival rate was not significantly lower (100%). Conclusion: This study found that these two types of early-onset endometrial cancer are clinicopathologically different. In patients with a family history of cancer, their body mass index was lower, and the frequency of G2 and G3 carcinoma was significantly higher, but their 5-year disease-free survival rate was not significantly lower.

AB - Aim: The number of patients under 40 years of age with early-onset endometrial cancer is on the rise in Japan. Preservation of fertility in younger patients is a critical issue. In order to examine the clinical and pathological characteristics of these patients, cases of early-onset endometrial cancer at a single hospital were analyzed. Methods: Seventy-four patients were diagnosed with endometrial cancer before age 40 and included in this study after obtaining informed consent. Results: The clinical characteristics included a significantly higher prevalence of complications such as nulligravidity and nulliparity (P < 0.001). Pathologically, well-differentiated endometrial carcinoma was significantly more frequent (P = 0.011). The 5-year survival rate was high (98.7%). In regards to the relationship between clinicopathological features and grade of differentiation, the prevalence of G2 and G3 carcinoma was not significantly lower (P = 0.24) in patients with obesity. Although the frequency of G2 and G3 carcinoma was significantly higher in patients with a family history of cancer (P = 0.02), their 5-year survival rate was not significantly lower (100%). Conclusion: This study found that these two types of early-onset endometrial cancer are clinicopathologically different. In patients with a family history of cancer, their body mass index was lower, and the frequency of G2 and G3 carcinoma was significantly higher, but their 5-year disease-free survival rate was not significantly lower.

KW - Endometrial cancer

KW - Family history of cancer

KW - HNPCC

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=27744586345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744586345&partnerID=8YFLogxK

U2 - 10.1111/j.1447-0756.2005.00318.x

DO - 10.1111/j.1447-0756.2005.00318.x

M3 - Article

C2 - 16176516

AN - SCOPUS:27744586345

VL - 31

SP - 444

EP - 451

JO - Asia-Oceania Journal of Obstetrics and Gynaecology

JF - Asia-Oceania Journal of Obstetrics and Gynaecology

SN - 1341-8076

IS - 5

ER -