Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma

Immunohistochemical analysis of 115 patients

Aya Nishizawa, Yukihiro Nakanishi, Kimio Yoshimura, Yuko Sasajima, Naoya Yamazaki, Akifumi Yamamoto, Katsumi Hanada, Yae Kanai, Setsuo Hirohashi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

BACKGROUND. The E-cadherin-mediated cell adhesion system is frequently inactivated by multiple mechanisms and is involved in tumor progression in many types of cancer. Recently, the authors reported a novel cell membrane glycoprotein, dysadherin, which has an anti-cell-cell adhesion function and down-regulates E-cadherin. METHODS. Expression of both dysadherin and E-cadherin was investigated immunohistochemically in 115 patients with cutaneous malignant melanoma to determine the correlation between the 2 molecules and their associations with both patient survival and the clinicopathologic features of the tumors. RESULTS. Dysadherin and E-cadherin were expressed at the cell membranes of melanoma cells. Fifty-two percent of the tumors showed dysadherin immunopositivity, and 91% of the tumors showed reduced E-cadherin immunopositivity. There was no significant inverse correlation between dysadherin expression and E-cadherin expression. Increased dysadherin expression was significantly correlated with nodular subtype (P = 0.042), Clark level (P < 0.001), tumor thickness (P < 0.001), ulceration (P = 0.008), lymph node metastasis (P < 0.001), high TNM classification (P < 0.001), and poor patient survival (P < 0.001). Multivariate analysis of patient survival revealed that increased dysadherin expression was a significant predictor of poor survival (P < 0.001). CONCLUSIONS. Thus, increased expression of dysadherin was a significant indicator of poor prognosis in patients with cutaneous malignant melanoma.

Original languageEnglish
Pages (from-to)1693-1700
Number of pages8
JournalCancer
Volume103
Issue number8
DOIs
Publication statusPublished - 2005 Apr 15
Externally publishedYes

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Cadherins
Neoplasms
Survival
Cell Adhesion
Cell Membrane
Neoplasm Staging
Membrane Glycoproteins
Cutaneous Malignant Melanoma
Melanoma
Down-Regulation
Multivariate Analysis
Lymph Nodes
Neoplasm Metastasis

Keywords

  • Clinicopathologic study
  • Cutaneous malignant melanoma
  • Dysadherin
  • E-cadherin
  • Immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma : Immunohistochemical analysis of 115 patients. / Nishizawa, Aya; Nakanishi, Yukihiro; Yoshimura, Kimio; Sasajima, Yuko; Yamazaki, Naoya; Yamamoto, Akifumi; Hanada, Katsumi; Kanai, Yae; Hirohashi, Setsuo.

In: Cancer, Vol. 103, No. 8, 15.04.2005, p. 1693-1700.

Research output: Contribution to journalArticle

Nishizawa, A, Nakanishi, Y, Yoshimura, K, Sasajima, Y, Yamazaki, N, Yamamoto, A, Hanada, K, Kanai, Y & Hirohashi, S 2005, 'Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: Immunohistochemical analysis of 115 patients', Cancer, vol. 103, no. 8, pp. 1693-1700. https://doi.org/10.1002/cncr.20984
Nishizawa, Aya ; Nakanishi, Yukihiro ; Yoshimura, Kimio ; Sasajima, Yuko ; Yamazaki, Naoya ; Yamamoto, Akifumi ; Hanada, Katsumi ; Kanai, Yae ; Hirohashi, Setsuo. / Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma : Immunohistochemical analysis of 115 patients. In: Cancer. 2005 ; Vol. 103, No. 8. pp. 1693-1700.
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AU - Sasajima, Yuko

AU - Yamazaki, Naoya

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AU - Kanai, Yae

AU - Hirohashi, Setsuo

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AB - BACKGROUND. The E-cadherin-mediated cell adhesion system is frequently inactivated by multiple mechanisms and is involved in tumor progression in many types of cancer. Recently, the authors reported a novel cell membrane glycoprotein, dysadherin, which has an anti-cell-cell adhesion function and down-regulates E-cadherin. METHODS. Expression of both dysadherin and E-cadherin was investigated immunohistochemically in 115 patients with cutaneous malignant melanoma to determine the correlation between the 2 molecules and their associations with both patient survival and the clinicopathologic features of the tumors. RESULTS. Dysadherin and E-cadherin were expressed at the cell membranes of melanoma cells. Fifty-two percent of the tumors showed dysadherin immunopositivity, and 91% of the tumors showed reduced E-cadherin immunopositivity. There was no significant inverse correlation between dysadherin expression and E-cadherin expression. Increased dysadherin expression was significantly correlated with nodular subtype (P = 0.042), Clark level (P < 0.001), tumor thickness (P < 0.001), ulceration (P = 0.008), lymph node metastasis (P < 0.001), high TNM classification (P < 0.001), and poor patient survival (P < 0.001). Multivariate analysis of patient survival revealed that increased dysadherin expression was a significant predictor of poor survival (P < 0.001). CONCLUSIONS. Thus, increased expression of dysadherin was a significant indicator of poor prognosis in patients with cutaneous malignant melanoma.

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