Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: Immunohistochemical analysis of 115 patients

Aya Nishizawa, Yukihiro Nakanishi, Kimio Yoshimura, Yuko Sasajima, Naoya Yamazaki, Akifumi Yamamoto, Katsumi Hanada, Yae Kanai, Setsuo Hirohashi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

BACKGROUND. The E-cadherin-mediated cell adhesion system is frequently inactivated by multiple mechanisms and is involved in tumor progression in many types of cancer. Recently, the authors reported a novel cell membrane glycoprotein, dysadherin, which has an anti-cell-cell adhesion function and down-regulates E-cadherin. METHODS. Expression of both dysadherin and E-cadherin was investigated immunohistochemically in 115 patients with cutaneous malignant melanoma to determine the correlation between the 2 molecules and their associations with both patient survival and the clinicopathologic features of the tumors. RESULTS. Dysadherin and E-cadherin were expressed at the cell membranes of melanoma cells. Fifty-two percent of the tumors showed dysadherin immunopositivity, and 91% of the tumors showed reduced E-cadherin immunopositivity. There was no significant inverse correlation between dysadherin expression and E-cadherin expression. Increased dysadherin expression was significantly correlated with nodular subtype (P = 0.042), Clark level (P < 0.001), tumor thickness (P < 0.001), ulceration (P = 0.008), lymph node metastasis (P < 0.001), high TNM classification (P < 0.001), and poor patient survival (P < 0.001). Multivariate analysis of patient survival revealed that increased dysadherin expression was a significant predictor of poor survival (P < 0.001). CONCLUSIONS. Thus, increased expression of dysadherin was a significant indicator of poor prognosis in patients with cutaneous malignant melanoma.

Original languageEnglish
Pages (from-to)1693-1700
Number of pages8
JournalCancer
Volume103
Issue number8
DOIs
Publication statusPublished - 2005 Apr 15
Externally publishedYes

Keywords

  • Clinicopathologic study
  • Cutaneous malignant melanoma
  • Dysadherin
  • E-cadherin
  • Immunohistochemistry

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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