TY - JOUR
T1 - Clinicopathological analysis of primary lung carcinoma with heterotopic ossification
AU - Kuribayashi, Hidehiko
AU - Tsuta, Koji
AU - Mizutani, Eiki
AU - Maeshima, Akiko Miyagi
AU - Yoshida, Yukihiro
AU - Gemma, Akihiko
AU - Kudoh, Shoji
AU - Asamura, Hisao
AU - Matsuno, Yoshihiro
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Pulmonary heterotopic ossification is an unusual event. The relationship between ossification and lung carcinoma is unclear. The present study analyzed clinicopathological features of primary lung carcinoma with heterotopic ossification. We reviewed 2269 surgically resected primary lung carcinomas and identified 33 with heterotopic ossification, including 15 cases with intratumoral heterotopic ossification (IHO) and 18 cases with extratumoral heterotopic ossification (EHO). All cases with IHO were adenocarcinomas and 10 of 15 (66.6%) cases had confirmed positive mucin staining in the tumor cells. Cases with EHO could be divided into three patterns, and each pattern is potentially associated with the background conditions of lung parenchyma. Immunohistochemistry, BMP-2 production was present in 13 of 15 (86.7%) cases with IHO, although, only 4 of 17 (23.5%) cases with EHO. A prognostic analysis revealed no statistically significant difference to be observed between adenocarcinomas with IHO and without IHO. The present study suggested that IHO associated with adenocarcinomas and BMP-2 production in the tumor cells, whereas EHO was not associated with the biology of the carcinoma.
AB - Pulmonary heterotopic ossification is an unusual event. The relationship between ossification and lung carcinoma is unclear. The present study analyzed clinicopathological features of primary lung carcinoma with heterotopic ossification. We reviewed 2269 surgically resected primary lung carcinomas and identified 33 with heterotopic ossification, including 15 cases with intratumoral heterotopic ossification (IHO) and 18 cases with extratumoral heterotopic ossification (EHO). All cases with IHO were adenocarcinomas and 10 of 15 (66.6%) cases had confirmed positive mucin staining in the tumor cells. Cases with EHO could be divided into three patterns, and each pattern is potentially associated with the background conditions of lung parenchyma. Immunohistochemistry, BMP-2 production was present in 13 of 15 (86.7%) cases with IHO, although, only 4 of 17 (23.5%) cases with EHO. A prognostic analysis revealed no statistically significant difference to be observed between adenocarcinomas with IHO and without IHO. The present study suggested that IHO associated with adenocarcinomas and BMP-2 production in the tumor cells, whereas EHO was not associated with the biology of the carcinoma.
KW - BMP-2
KW - Heterotopic bone formation
KW - Lung cancer
KW - Ossification
KW - Primary
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UR - http://www.scopus.com/inward/citedby.url?scp=63049124801&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2008.08.007
DO - 10.1016/j.lungcan.2008.08.007
M3 - Article
C2 - 18819725
AN - SCOPUS:63049124801
SN - 0169-5002
VL - 64
SP - 160
EP - 165
JO - Lung Cancer
JF - Lung Cancer
IS - 2
ER -
