Clinicopathological characteristics of intrahepatic cholangiocellular carcinoma presenting intrahepatic bile duct growth

Yusuke Yamamoto, Kazuaki Shimada, Yoshihiro Sakamoto, Minoru Esaki, Satoshi Nara, Daisuke Ban, Tomoo Kosuge, Hidenori Ojima

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Intrahepatic cholangiocellular carcinoma (ICC) presenting intraductal growth (IG) has distinct clinicopathological features with a favorable prognosis. The mass-forming (MF) plus IG type of ICC has not been previously investigated. Methods: One hundred forty-four patients with ICC underwent surgical resections and were classified according to the macroscopic type. The clinicopathological features of the IG type (n=7) and MF plus IG type (n=14) were retrospectively analyzed. The clinicopathological differences between the MF plus IG type and MF plus periductal infiltrating (PI) type (n=37) were compared. Results: All of the patients with the IG type had no sign of recurrence and survived. The 5-year overall survival rates was significantly better in the MF plus IG type than in the MF plus PI type (41.3% vs. 13.3%, P=0.034). Significant differences were recognized between the MF plus IG type and MF plus PI type, in terms of vascular resection (P=0.030), mucosal extension (P=0.006), and postoperative recurrence (P=0.004). Conclusions: The MF plus IG type had significantly better prognosis than the MF plus PI type. The IG type and MF plus IG type should be distinguished from other types even if hepatic hilar confluence is involved, because of the favorable outcome after surgery.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalJournal of Surgical Oncology
Volume99
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1
Externally publishedYes

Fingerprint

Intrahepatic Bile Ducts
Cholangiocarcinoma
Growth
Recurrence
Blood Vessels
Survival Rate

Keywords

  • Intraductal growth type
  • Intrahepatic cholangiocellular carcinoma
  • Mass-forming plus intraductal growth type
  • Surgical resection

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Clinicopathological characteristics of intrahepatic cholangiocellular carcinoma presenting intrahepatic bile duct growth. / Yamamoto, Yusuke; Shimada, Kazuaki; Sakamoto, Yoshihiro; Esaki, Minoru; Nara, Satoshi; Ban, Daisuke; Kosuge, Tomoo; Ojima, Hidenori.

In: Journal of Surgical Oncology, Vol. 99, No. 3, 01.03.2009, p. 161-165.

Research output: Contribution to journalArticle

Yamamoto, Yusuke ; Shimada, Kazuaki ; Sakamoto, Yoshihiro ; Esaki, Minoru ; Nara, Satoshi ; Ban, Daisuke ; Kosuge, Tomoo ; Ojima, Hidenori. / Clinicopathological characteristics of intrahepatic cholangiocellular carcinoma presenting intrahepatic bile duct growth. In: Journal of Surgical Oncology. 2009 ; Vol. 99, No. 3. pp. 161-165.
@article{be5f091b7af34b31bb20ca2810ebf5c2,
title = "Clinicopathological characteristics of intrahepatic cholangiocellular carcinoma presenting intrahepatic bile duct growth",
abstract = "Background: Intrahepatic cholangiocellular carcinoma (ICC) presenting intraductal growth (IG) has distinct clinicopathological features with a favorable prognosis. The mass-forming (MF) plus IG type of ICC has not been previously investigated. Methods: One hundred forty-four patients with ICC underwent surgical resections and were classified according to the macroscopic type. The clinicopathological features of the IG type (n=7) and MF plus IG type (n=14) were retrospectively analyzed. The clinicopathological differences between the MF plus IG type and MF plus periductal infiltrating (PI) type (n=37) were compared. Results: All of the patients with the IG type had no sign of recurrence and survived. The 5-year overall survival rates was significantly better in the MF plus IG type than in the MF plus PI type (41.3{\%} vs. 13.3{\%}, P=0.034). Significant differences were recognized between the MF plus IG type and MF plus PI type, in terms of vascular resection (P=0.030), mucosal extension (P=0.006), and postoperative recurrence (P=0.004). Conclusions: The MF plus IG type had significantly better prognosis than the MF plus PI type. The IG type and MF plus IG type should be distinguished from other types even if hepatic hilar confluence is involved, because of the favorable outcome after surgery.",
keywords = "Intraductal growth type, Intrahepatic cholangiocellular carcinoma, Mass-forming plus intraductal growth type, Surgical resection",
author = "Yusuke Yamamoto and Kazuaki Shimada and Yoshihiro Sakamoto and Minoru Esaki and Satoshi Nara and Daisuke Ban and Tomoo Kosuge and Hidenori Ojima",
year = "2009",
month = "3",
day = "1",
doi = "10.1002/jso.21214",
language = "English",
volume = "99",
pages = "161--165",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Clinicopathological characteristics of intrahepatic cholangiocellular carcinoma presenting intrahepatic bile duct growth

AU - Yamamoto, Yusuke

AU - Shimada, Kazuaki

AU - Sakamoto, Yoshihiro

AU - Esaki, Minoru

AU - Nara, Satoshi

AU - Ban, Daisuke

AU - Kosuge, Tomoo

AU - Ojima, Hidenori

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Background: Intrahepatic cholangiocellular carcinoma (ICC) presenting intraductal growth (IG) has distinct clinicopathological features with a favorable prognosis. The mass-forming (MF) plus IG type of ICC has not been previously investigated. Methods: One hundred forty-four patients with ICC underwent surgical resections and were classified according to the macroscopic type. The clinicopathological features of the IG type (n=7) and MF plus IG type (n=14) were retrospectively analyzed. The clinicopathological differences between the MF plus IG type and MF plus periductal infiltrating (PI) type (n=37) were compared. Results: All of the patients with the IG type had no sign of recurrence and survived. The 5-year overall survival rates was significantly better in the MF plus IG type than in the MF plus PI type (41.3% vs. 13.3%, P=0.034). Significant differences were recognized between the MF plus IG type and MF plus PI type, in terms of vascular resection (P=0.030), mucosal extension (P=0.006), and postoperative recurrence (P=0.004). Conclusions: The MF plus IG type had significantly better prognosis than the MF plus PI type. The IG type and MF plus IG type should be distinguished from other types even if hepatic hilar confluence is involved, because of the favorable outcome after surgery.

AB - Background: Intrahepatic cholangiocellular carcinoma (ICC) presenting intraductal growth (IG) has distinct clinicopathological features with a favorable prognosis. The mass-forming (MF) plus IG type of ICC has not been previously investigated. Methods: One hundred forty-four patients with ICC underwent surgical resections and were classified according to the macroscopic type. The clinicopathological features of the IG type (n=7) and MF plus IG type (n=14) were retrospectively analyzed. The clinicopathological differences between the MF plus IG type and MF plus periductal infiltrating (PI) type (n=37) were compared. Results: All of the patients with the IG type had no sign of recurrence and survived. The 5-year overall survival rates was significantly better in the MF plus IG type than in the MF plus PI type (41.3% vs. 13.3%, P=0.034). Significant differences were recognized between the MF plus IG type and MF plus PI type, in terms of vascular resection (P=0.030), mucosal extension (P=0.006), and postoperative recurrence (P=0.004). Conclusions: The MF plus IG type had significantly better prognosis than the MF plus PI type. The IG type and MF plus IG type should be distinguished from other types even if hepatic hilar confluence is involved, because of the favorable outcome after surgery.

KW - Intraductal growth type

KW - Intrahepatic cholangiocellular carcinoma

KW - Mass-forming plus intraductal growth type

KW - Surgical resection

UR - http://www.scopus.com/inward/record.url?scp=61449196852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61449196852&partnerID=8YFLogxK

U2 - 10.1002/jso.21214

DO - 10.1002/jso.21214

M3 - Article

C2 - 19101954

AN - SCOPUS:61449196852

VL - 99

SP - 161

EP - 165

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 3

ER -