Clinicopathological features and surgical outcome of isolated metastasis of renal cell carcinoma

Tomotaka Akatsu, Motohide Shimazu, Koichi Aiura, Yasuhiro Ito, Masahiro Shinoda, Shigeyuki Kawachi, Minoru Tanabe, Masakazu Ueda, Masaki Kitajima, Yuukou Kitagawa

Research output: Contribution to journalArticle

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Abstract

Background/Aims: The benefit of pancreatic resection for metastatic renal cell carcinoma (RCC) is poorly defined. Here, we investigate the clinicopathological features and surgical outcome of patients with pancreatic metastasis from RCC. Methodology: Among a total of 131 patients who underwent pancreatic resection at our center between November 2000 and November 2005, four patients (three men, one woman) with a median age of 57 years (range: 52-80 years) at the time of pancreatic tumor presentation, had histologically confirmed metastatic RCC to the pancreas. The medical records, imaging data, surgical records, and pathology findings of these patients were reviewed retrospectively. Results: All patients underwent radical nephrectomy for primary RCC. The pathologic stage was TNM stage T2N0M0 (n = 1) or T3aN0M0 (n = 2) (no data were available on one patient). RCCs developed in the right (n = 2) or left (n = 2) kidney. The median interval between nephrectomy and detection of pancreatic metastasis was 84 months (range: 0-285 months). All patients were asymptomatic, and the pancreatic masses with a median tumor diameter of 2.0cm (range: 1.5-4.0cm) were detected during routine follow-up or screening examinations. All pancreatic tumors were smooth, well-demarcated, and hypervascular on imaging studies. None of them showed evidence of associated extrapancreatic disease. Complete resection with an adequate margin of safety was achieved by distal pancreatectomy (n = 3) or pylorus-preserving pancreatoduodenectomy (n = 1). Within a median follow-up period of 39 months (range: 4-41 months) after the surgery, three patients were alive with no evidence of recurrence, and one patient was alive with evidence of recurrence. The median survival from nephrectomy was 103 months (range: 40-326 months). Conclusions: RCCs may demonstrate very late metastasis to the pancreas, thus the possibility of pancreatic metastasis should be considered when a patient with a pancreatic tumor has a history of RCC, despite the interval since nephrectomy. The experience gained in this study suggests that pancreatic metastasectomy should be attempted for RCC patients without extrapancreatic disease.

Original languageEnglish
Pages (from-to)1836-1840
Number of pages5
JournalHepato-Gastroenterology
Volume54
Issue number78
Publication statusPublished - 2007 Sep

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Renal Cell Carcinoma
Neoplasm Metastasis
Nephrectomy
Pancreas
Neoplasms
Metastasectomy
Recurrence
Surgical Pathology
Pancreatectomy
Pancreaticoduodenectomy
Pylorus
Diagnostic Imaging
Medical Records
Kidney
Safety
Survival

Keywords

  • Metastasis
  • Pancreas
  • Renal cell carcinoma
  • Resection

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Clinicopathological features and surgical outcome of isolated metastasis of renal cell carcinoma. / Akatsu, Tomotaka; Shimazu, Motohide; Aiura, Koichi; Ito, Yasuhiro; Shinoda, Masahiro; Kawachi, Shigeyuki; Tanabe, Minoru; Ueda, Masakazu; Kitajima, Masaki; Kitagawa, Yuukou.

In: Hepato-Gastroenterology, Vol. 54, No. 78, 09.2007, p. 1836-1840.

Research output: Contribution to journalArticle

Akatsu, T, Shimazu, M, Aiura, K, Ito, Y, Shinoda, M, Kawachi, S, Tanabe, M, Ueda, M, Kitajima, M & Kitagawa, Y 2007, 'Clinicopathological features and surgical outcome of isolated metastasis of renal cell carcinoma', Hepato-Gastroenterology, vol. 54, no. 78, pp. 1836-1840.
Akatsu, Tomotaka ; Shimazu, Motohide ; Aiura, Koichi ; Ito, Yasuhiro ; Shinoda, Masahiro ; Kawachi, Shigeyuki ; Tanabe, Minoru ; Ueda, Masakazu ; Kitajima, Masaki ; Kitagawa, Yuukou. / Clinicopathological features and surgical outcome of isolated metastasis of renal cell carcinoma. In: Hepato-Gastroenterology. 2007 ; Vol. 54, No. 78. pp. 1836-1840.
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abstract = "Background/Aims: The benefit of pancreatic resection for metastatic renal cell carcinoma (RCC) is poorly defined. Here, we investigate the clinicopathological features and surgical outcome of patients with pancreatic metastasis from RCC. Methodology: Among a total of 131 patients who underwent pancreatic resection at our center between November 2000 and November 2005, four patients (three men, one woman) with a median age of 57 years (range: 52-80 years) at the time of pancreatic tumor presentation, had histologically confirmed metastatic RCC to the pancreas. The medical records, imaging data, surgical records, and pathology findings of these patients were reviewed retrospectively. Results: All patients underwent radical nephrectomy for primary RCC. The pathologic stage was TNM stage T2N0M0 (n = 1) or T3aN0M0 (n = 2) (no data were available on one patient). RCCs developed in the right (n = 2) or left (n = 2) kidney. The median interval between nephrectomy and detection of pancreatic metastasis was 84 months (range: 0-285 months). All patients were asymptomatic, and the pancreatic masses with a median tumor diameter of 2.0cm (range: 1.5-4.0cm) were detected during routine follow-up or screening examinations. All pancreatic tumors were smooth, well-demarcated, and hypervascular on imaging studies. None of them showed evidence of associated extrapancreatic disease. Complete resection with an adequate margin of safety was achieved by distal pancreatectomy (n = 3) or pylorus-preserving pancreatoduodenectomy (n = 1). Within a median follow-up period of 39 months (range: 4-41 months) after the surgery, three patients were alive with no evidence of recurrence, and one patient was alive with evidence of recurrence. The median survival from nephrectomy was 103 months (range: 40-326 months). Conclusions: RCCs may demonstrate very late metastasis to the pancreas, thus the possibility of pancreatic metastasis should be considered when a patient with a pancreatic tumor has a history of RCC, despite the interval since nephrectomy. The experience gained in this study suggests that pancreatic metastasectomy should be attempted for RCC patients without extrapancreatic disease.",
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AU - Akatsu, Tomotaka

AU - Shimazu, Motohide

AU - Aiura, Koichi

AU - Ito, Yasuhiro

AU - Shinoda, Masahiro

AU - Kawachi, Shigeyuki

AU - Tanabe, Minoru

AU - Ueda, Masakazu

AU - Kitajima, Masaki

AU - Kitagawa, Yuukou

PY - 2007/9

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N2 - Background/Aims: The benefit of pancreatic resection for metastatic renal cell carcinoma (RCC) is poorly defined. Here, we investigate the clinicopathological features and surgical outcome of patients with pancreatic metastasis from RCC. Methodology: Among a total of 131 patients who underwent pancreatic resection at our center between November 2000 and November 2005, four patients (three men, one woman) with a median age of 57 years (range: 52-80 years) at the time of pancreatic tumor presentation, had histologically confirmed metastatic RCC to the pancreas. The medical records, imaging data, surgical records, and pathology findings of these patients were reviewed retrospectively. Results: All patients underwent radical nephrectomy for primary RCC. The pathologic stage was TNM stage T2N0M0 (n = 1) or T3aN0M0 (n = 2) (no data were available on one patient). RCCs developed in the right (n = 2) or left (n = 2) kidney. The median interval between nephrectomy and detection of pancreatic metastasis was 84 months (range: 0-285 months). All patients were asymptomatic, and the pancreatic masses with a median tumor diameter of 2.0cm (range: 1.5-4.0cm) were detected during routine follow-up or screening examinations. All pancreatic tumors were smooth, well-demarcated, and hypervascular on imaging studies. None of them showed evidence of associated extrapancreatic disease. Complete resection with an adequate margin of safety was achieved by distal pancreatectomy (n = 3) or pylorus-preserving pancreatoduodenectomy (n = 1). Within a median follow-up period of 39 months (range: 4-41 months) after the surgery, three patients were alive with no evidence of recurrence, and one patient was alive with evidence of recurrence. The median survival from nephrectomy was 103 months (range: 40-326 months). Conclusions: RCCs may demonstrate very late metastasis to the pancreas, thus the possibility of pancreatic metastasis should be considered when a patient with a pancreatic tumor has a history of RCC, despite the interval since nephrectomy. The experience gained in this study suggests that pancreatic metastasectomy should be attempted for RCC patients without extrapancreatic disease.

AB - Background/Aims: The benefit of pancreatic resection for metastatic renal cell carcinoma (RCC) is poorly defined. Here, we investigate the clinicopathological features and surgical outcome of patients with pancreatic metastasis from RCC. Methodology: Among a total of 131 patients who underwent pancreatic resection at our center between November 2000 and November 2005, four patients (three men, one woman) with a median age of 57 years (range: 52-80 years) at the time of pancreatic tumor presentation, had histologically confirmed metastatic RCC to the pancreas. The medical records, imaging data, surgical records, and pathology findings of these patients were reviewed retrospectively. Results: All patients underwent radical nephrectomy for primary RCC. The pathologic stage was TNM stage T2N0M0 (n = 1) or T3aN0M0 (n = 2) (no data were available on one patient). RCCs developed in the right (n = 2) or left (n = 2) kidney. The median interval between nephrectomy and detection of pancreatic metastasis was 84 months (range: 0-285 months). All patients were asymptomatic, and the pancreatic masses with a median tumor diameter of 2.0cm (range: 1.5-4.0cm) were detected during routine follow-up or screening examinations. All pancreatic tumors were smooth, well-demarcated, and hypervascular on imaging studies. None of them showed evidence of associated extrapancreatic disease. Complete resection with an adequate margin of safety was achieved by distal pancreatectomy (n = 3) or pylorus-preserving pancreatoduodenectomy (n = 1). Within a median follow-up period of 39 months (range: 4-41 months) after the surgery, three patients were alive with no evidence of recurrence, and one patient was alive with evidence of recurrence. The median survival from nephrectomy was 103 months (range: 40-326 months). Conclusions: RCCs may demonstrate very late metastasis to the pancreas, thus the possibility of pancreatic metastasis should be considered when a patient with a pancreatic tumor has a history of RCC, despite the interval since nephrectomy. The experience gained in this study suggests that pancreatic metastasectomy should be attempted for RCC patients without extrapancreatic disease.

KW - Metastasis

KW - Pancreas

KW - Renal cell carcinoma

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