Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma

Kei Shimizu, Keisuke Kirita, Keiju Aokage, Motohiro Kojima, Tomoyuki Hishida, Takeshi Kuwata, Satoshi Fujii, Atsushi Ochiai, Kazuhito Funai, Junji Yoshida, Masahiro Tsuboi, Genichiro Ishii

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Caveolin is an essential constituent of caveolae and has many biological functions. Expression of caveolin-1 in cancer cells was reported to be a prognostic marker in several types of cancers, the prognostic significance of its expression in cancer-associated fibroblasts (CAFs) has not been investigated. This study aimed to evaluate the clinicopathological significance of expression by CAFs in lung adenocarcinoma. Methods: We examined caveolin-1 expression in both CAFs and cancer cells in stage I invasive lung adenocarcinoma (n = 412) and analyzed the relationship between the expression and clinicopathological factors. Results: Caveolin-1 expression by CAFs and cancer cells was observed in 12.1% and 7.8% of adenocarcinomas, respectively. Tumors with caveolin-1-positive CAFs had vascular and pleural invasion significantly more frequently than those with caveolin-1-negative CAF (p < 0.05). This was also the cases with tumors with caveolin-1-positive cancer cells (p < 0.01). Caveolin-1 expression by CAFs and that by cancer cells were significant predictors of shorter recurrence-free survival (p < 0.001). Caveolin-1 expression by CAFs and cancer cells was found in 25% and 30% of solid predominant subtype, respectively, but only 9.2% and 2.7% of non-solid predominant subtype, respectively. The frequency of cases with caveolin-1-positive CAFs or cancer cells was significantly higher in the solid predominant subtype than in non-solid predominant subtype (p < 0.001). Conclusions: Our current results highlight the prognostic importance of caveolin-1 expression by CAFs in stage I lung adenocarcinoma and provide new insights into the biological significance of caveolin-1 in the tumor microenvironment, especially in microenvironment of solid predominant adenocarcinoma.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalJournal of Cancer Research and Clinical Oncology
Volume143
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1
Externally publishedYes

Fingerprint

Caveolin 1
Neoplasms
Adenocarcinoma
Cancer-Associated Fibroblasts
Adenocarcinoma of lung
Caveolins
Caveolae
Tumor Microenvironment
Blood Vessels

Keywords

  • Cancer-associated fibroblast
  • Caveolin-1
  • Lung adenocarcinoma
  • Progression-free survival
  • Solid predominant subtype
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma. / Shimizu, Kei; Kirita, Keisuke; Aokage, Keiju; Kojima, Motohiro; Hishida, Tomoyuki; Kuwata, Takeshi; Fujii, Satoshi; Ochiai, Atsushi; Funai, Kazuhito; Yoshida, Junji; Tsuboi, Masahiro; Ishii, Genichiro.

In: Journal of Cancer Research and Clinical Oncology, Vol. 143, No. 2, 01.02.2017, p. 321-328.

Research output: Contribution to journalArticle

Shimizu, K, Kirita, K, Aokage, K, Kojima, M, Hishida, T, Kuwata, T, Fujii, S, Ochiai, A, Funai, K, Yoshida, J, Tsuboi, M & Ishii, G 2017, 'Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma', Journal of Cancer Research and Clinical Oncology, vol. 143, no. 2, pp. 321-328. https://doi.org/10.1007/s00432-016-2285-2
Shimizu, Kei ; Kirita, Keisuke ; Aokage, Keiju ; Kojima, Motohiro ; Hishida, Tomoyuki ; Kuwata, Takeshi ; Fujii, Satoshi ; Ochiai, Atsushi ; Funai, Kazuhito ; Yoshida, Junji ; Tsuboi, Masahiro ; Ishii, Genichiro. / Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma. In: Journal of Cancer Research and Clinical Oncology. 2017 ; Vol. 143, No. 2. pp. 321-328.
@article{303a3e5f4d614b249c96da412c85761d,
title = "Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma",
abstract = "Purpose: Caveolin is an essential constituent of caveolae and has many biological functions. Expression of caveolin-1 in cancer cells was reported to be a prognostic marker in several types of cancers, the prognostic significance of its expression in cancer-associated fibroblasts (CAFs) has not been investigated. This study aimed to evaluate the clinicopathological significance of expression by CAFs in lung adenocarcinoma. Methods: We examined caveolin-1 expression in both CAFs and cancer cells in stage I invasive lung adenocarcinoma (n = 412) and analyzed the relationship between the expression and clinicopathological factors. Results: Caveolin-1 expression by CAFs and cancer cells was observed in 12.1{\%} and 7.8{\%} of adenocarcinomas, respectively. Tumors with caveolin-1-positive CAFs had vascular and pleural invasion significantly more frequently than those with caveolin-1-negative CAF (p < 0.05). This was also the cases with tumors with caveolin-1-positive cancer cells (p < 0.01). Caveolin-1 expression by CAFs and that by cancer cells were significant predictors of shorter recurrence-free survival (p < 0.001). Caveolin-1 expression by CAFs and cancer cells was found in 25{\%} and 30{\%} of solid predominant subtype, respectively, but only 9.2{\%} and 2.7{\%} of non-solid predominant subtype, respectively. The frequency of cases with caveolin-1-positive CAFs or cancer cells was significantly higher in the solid predominant subtype than in non-solid predominant subtype (p < 0.001). Conclusions: Our current results highlight the prognostic importance of caveolin-1 expression by CAFs in stage I lung adenocarcinoma and provide new insights into the biological significance of caveolin-1 in the tumor microenvironment, especially in microenvironment of solid predominant adenocarcinoma.",
keywords = "Cancer-associated fibroblast, Caveolin-1, Lung adenocarcinoma, Progression-free survival, Solid predominant subtype, Surgery",
author = "Kei Shimizu and Keisuke Kirita and Keiju Aokage and Motohiro Kojima and Tomoyuki Hishida and Takeshi Kuwata and Satoshi Fujii and Atsushi Ochiai and Kazuhito Funai and Junji Yoshida and Masahiro Tsuboi and Genichiro Ishii",
year = "2017",
month = "2",
day = "1",
doi = "10.1007/s00432-016-2285-2",
language = "English",
volume = "143",
pages = "321--328",
journal = "Journal of Cancer Research and Clinical Oncology",
issn = "0171-5216",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma

AU - Shimizu, Kei

AU - Kirita, Keisuke

AU - Aokage, Keiju

AU - Kojima, Motohiro

AU - Hishida, Tomoyuki

AU - Kuwata, Takeshi

AU - Fujii, Satoshi

AU - Ochiai, Atsushi

AU - Funai, Kazuhito

AU - Yoshida, Junji

AU - Tsuboi, Masahiro

AU - Ishii, Genichiro

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Purpose: Caveolin is an essential constituent of caveolae and has many biological functions. Expression of caveolin-1 in cancer cells was reported to be a prognostic marker in several types of cancers, the prognostic significance of its expression in cancer-associated fibroblasts (CAFs) has not been investigated. This study aimed to evaluate the clinicopathological significance of expression by CAFs in lung adenocarcinoma. Methods: We examined caveolin-1 expression in both CAFs and cancer cells in stage I invasive lung adenocarcinoma (n = 412) and analyzed the relationship between the expression and clinicopathological factors. Results: Caveolin-1 expression by CAFs and cancer cells was observed in 12.1% and 7.8% of adenocarcinomas, respectively. Tumors with caveolin-1-positive CAFs had vascular and pleural invasion significantly more frequently than those with caveolin-1-negative CAF (p < 0.05). This was also the cases with tumors with caveolin-1-positive cancer cells (p < 0.01). Caveolin-1 expression by CAFs and that by cancer cells were significant predictors of shorter recurrence-free survival (p < 0.001). Caveolin-1 expression by CAFs and cancer cells was found in 25% and 30% of solid predominant subtype, respectively, but only 9.2% and 2.7% of non-solid predominant subtype, respectively. The frequency of cases with caveolin-1-positive CAFs or cancer cells was significantly higher in the solid predominant subtype than in non-solid predominant subtype (p < 0.001). Conclusions: Our current results highlight the prognostic importance of caveolin-1 expression by CAFs in stage I lung adenocarcinoma and provide new insights into the biological significance of caveolin-1 in the tumor microenvironment, especially in microenvironment of solid predominant adenocarcinoma.

AB - Purpose: Caveolin is an essential constituent of caveolae and has many biological functions. Expression of caveolin-1 in cancer cells was reported to be a prognostic marker in several types of cancers, the prognostic significance of its expression in cancer-associated fibroblasts (CAFs) has not been investigated. This study aimed to evaluate the clinicopathological significance of expression by CAFs in lung adenocarcinoma. Methods: We examined caveolin-1 expression in both CAFs and cancer cells in stage I invasive lung adenocarcinoma (n = 412) and analyzed the relationship between the expression and clinicopathological factors. Results: Caveolin-1 expression by CAFs and cancer cells was observed in 12.1% and 7.8% of adenocarcinomas, respectively. Tumors with caveolin-1-positive CAFs had vascular and pleural invasion significantly more frequently than those with caveolin-1-negative CAF (p < 0.05). This was also the cases with tumors with caveolin-1-positive cancer cells (p < 0.01). Caveolin-1 expression by CAFs and that by cancer cells were significant predictors of shorter recurrence-free survival (p < 0.001). Caveolin-1 expression by CAFs and cancer cells was found in 25% and 30% of solid predominant subtype, respectively, but only 9.2% and 2.7% of non-solid predominant subtype, respectively. The frequency of cases with caveolin-1-positive CAFs or cancer cells was significantly higher in the solid predominant subtype than in non-solid predominant subtype (p < 0.001). Conclusions: Our current results highlight the prognostic importance of caveolin-1 expression by CAFs in stage I lung adenocarcinoma and provide new insights into the biological significance of caveolin-1 in the tumor microenvironment, especially in microenvironment of solid predominant adenocarcinoma.

KW - Cancer-associated fibroblast

KW - Caveolin-1

KW - Lung adenocarcinoma

KW - Progression-free survival

KW - Solid predominant subtype

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=84992055599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992055599&partnerID=8YFLogxK

U2 - 10.1007/s00432-016-2285-2

DO - 10.1007/s00432-016-2285-2

M3 - Article

VL - 143

SP - 321

EP - 328

JO - Journal of Cancer Research and Clinical Oncology

JF - Journal of Cancer Research and Clinical Oncology

SN - 0171-5216

IS - 2

ER -