Clinicopathological significance of growth factors and their receptors as potential therapeutic targets for biliary tract carcinoma

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1 Citation (Scopus)

Abstract

Biliary tract carcinoma (BTC) has a poor prognosis. However, no standard chemotherapy regimens have been established for inoperable cases or cases of recurrence after surgical resection. Recent molecular biological analysis has shown that epidermal growth factor receptor, human epidermal growth factor receptor 2, vascular endothelial growth factor, hepatocyte growth factor, c-Met and transforming growth factor-beta could be potential targets for therapy of BTC. It is considered that these molecules are involved in the carcinogenesis, invasion, and progression of BTC. Furthermore, immunohistochemical overexpression of these targets is associated with several clinicopathological factors. This article reviews the clinicopathological significance of these growth factors and their receptors.

Original languageEnglish
Pages (from-to)319-325
Number of pages7
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume19
Issue number4
DOIs
Publication statusPublished - 2012 Jul
Externally publishedYes

Fingerprint

Growth Factor Receptors
Biliary Tract
Carcinoma
Hepatocyte Growth Factor
Epidermal Growth Factor Receptor
Transforming Growth Factor beta
Vascular Endothelial Growth Factor A
Carcinogenesis
Therapeutics
Recurrence
Drug Therapy

Keywords

  • Biliary tract carcinoma
  • Chemotherapy
  • Growth factor receptor
  • Immunohistochemistry
  • Molecular target

ASJC Scopus subject areas

  • Hepatology
  • Surgery

Cite this

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AB - Biliary tract carcinoma (BTC) has a poor prognosis. However, no standard chemotherapy regimens have been established for inoperable cases or cases of recurrence after surgical resection. Recent molecular biological analysis has shown that epidermal growth factor receptor, human epidermal growth factor receptor 2, vascular endothelial growth factor, hepatocyte growth factor, c-Met and transforming growth factor-beta could be potential targets for therapy of BTC. It is considered that these molecules are involved in the carcinogenesis, invasion, and progression of BTC. Furthermore, immunohistochemical overexpression of these targets is associated with several clinicopathological factors. This article reviews the clinicopathological significance of these growth factors and their receptors.

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