Abstract
Renal cell carcinoma (RCC) with t(6;11)(p21;q12) has been incorporated into the recent WHO classification. We performed a clinicopathological study of 5 cases with such a tumor. The patients consisted of 4 males and 1 female. The age of patients ranged from 17 to 57 years with a mean age of 38.6 years. Tumor sizes ranged from 2.8 to 11 cm with a mean value of 6.5 cm. Despite immunotherapy and molecular-targeted therapy, one patient died of the disease 28 months after the surgery. Grossly, the cut surface of this tumor showed grayish white color in at least the focal area of all tumors. Furthermore, hemorrhage, daughter nodules and cystic changes were observed in two, three, and two tumors, respectively. Morpho-logically, all the tumors consisted of two components of large cells and small cells, and the latter surrounded basement membrane-like materials, forming rosette-like structures. Immunohistochemically, nuclei of tumor cells in all cases were positive for TFEB. Fluorescence in situ hybridization study confirmed the TFEB gene break in two tumors. Finally, urologists and pathologists should bear in mind that this tumor may occur in young adults to adults and might behave in an aggressive fashion. Break-apart FISH is useful for the definite diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 66-72 |
| Number of pages | 7 |
| Journal | Polish Journal of Pathology |
| Volume | 68 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 |
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Keywords
- Renal cell carcinoma
- T(6; 11)
- TFEB
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)
Cite this
Clinicopathological study of 5 cases of renal cell carcinoma with t(6;11)(p21;q12). / Kuroda, Naoto; Yorita, Kenji; Sasaki, Naomi; Ishihara, Akira; Matsuura, Keiko; Daa, Tsutomu; Mori, Shintaro; Sasaki, Aya; Mikami, Shuji; Shigematsu, Kazuto; Nagashima, Yoji.
In: Polish Journal of Pathology, Vol. 68, No. 1, 2017, p. 66-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinicopathological study of 5 cases of renal cell carcinoma with t(6;11)(p21;q12)
AU - Kuroda, Naoto
AU - Yorita, Kenji
AU - Sasaki, Naomi
AU - Ishihara, Akira
AU - Matsuura, Keiko
AU - Daa, Tsutomu
AU - Mori, Shintaro
AU - Sasaki, Aya
AU - Mikami, Shuji
AU - Shigematsu, Kazuto
AU - Nagashima, Yoji
PY - 2017
Y1 - 2017
N2 - Renal cell carcinoma (RCC) with t(6;11)(p21;q12) has been incorporated into the recent WHO classification. We performed a clinicopathological study of 5 cases with such a tumor. The patients consisted of 4 males and 1 female. The age of patients ranged from 17 to 57 years with a mean age of 38.6 years. Tumor sizes ranged from 2.8 to 11 cm with a mean value of 6.5 cm. Despite immunotherapy and molecular-targeted therapy, one patient died of the disease 28 months after the surgery. Grossly, the cut surface of this tumor showed grayish white color in at least the focal area of all tumors. Furthermore, hemorrhage, daughter nodules and cystic changes were observed in two, three, and two tumors, respectively. Morpho-logically, all the tumors consisted of two components of large cells and small cells, and the latter surrounded basement membrane-like materials, forming rosette-like structures. Immunohistochemically, nuclei of tumor cells in all cases were positive for TFEB. Fluorescence in situ hybridization study confirmed the TFEB gene break in two tumors. Finally, urologists and pathologists should bear in mind that this tumor may occur in young adults to adults and might behave in an aggressive fashion. Break-apart FISH is useful for the definite diagnosis.
AB - Renal cell carcinoma (RCC) with t(6;11)(p21;q12) has been incorporated into the recent WHO classification. We performed a clinicopathological study of 5 cases with such a tumor. The patients consisted of 4 males and 1 female. The age of patients ranged from 17 to 57 years with a mean age of 38.6 years. Tumor sizes ranged from 2.8 to 11 cm with a mean value of 6.5 cm. Despite immunotherapy and molecular-targeted therapy, one patient died of the disease 28 months after the surgery. Grossly, the cut surface of this tumor showed grayish white color in at least the focal area of all tumors. Furthermore, hemorrhage, daughter nodules and cystic changes were observed in two, three, and two tumors, respectively. Morpho-logically, all the tumors consisted of two components of large cells and small cells, and the latter surrounded basement membrane-like materials, forming rosette-like structures. Immunohistochemically, nuclei of tumor cells in all cases were positive for TFEB. Fluorescence in situ hybridization study confirmed the TFEB gene break in two tumors. Finally, urologists and pathologists should bear in mind that this tumor may occur in young adults to adults and might behave in an aggressive fashion. Break-apart FISH is useful for the definite diagnosis.
KW - Renal cell carcinoma
KW - T(6; 11)
KW - TFEB
UR - http://www.scopus.com/inward/record.url?scp=85019761377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019761377&partnerID=8YFLogxK
U2 - 10.5114/pjp.2017.67617
DO - 10.5114/pjp.2017.67617
M3 - Article
C2 - 28547982
AN - SCOPUS:85019761377
VL - 68
SP - 66
EP - 72
JO - Polish Journal of Pathology
JF - Polish Journal of Pathology
SN - 1233-9687
IS - 1
ER -