Cloning a novel developmental regulating gene, Xotx5: Its potential role in anterior formation in Xenopus laevis

Hiroki Kuroda, Tadayoshi Hayata, Akira Eisaki, Makoto Asashima

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The vertebrate Otx gene family is related to otd, a gene contributing to head development in Drosophila. In Xenopus, Xotx1, Xotx2, and Xotx4 have already been isolated and analyzed. Here the cloning, developmental expression and functions of the additional Otx Xenopus gene, Xotx5 are reported. This latter gene shows a greater degree of homology to Xotx2 than Xotx1 and Xotx4. Xotx5 was initially expressed in Spemann's organizer and later in the anterior region. Ectopic expression of Xotx5 had similar effects to other Xotx genes in impairing trunk and tail development, and especially similar effects to Xotx2 in causing secondary cement glands. Taken together, these findings suggest that Xotx5 stimulates the formation of the anterior regions and represses the formation of posterior structures similar to Xotx2.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalDevelopment Growth and Differentiation
Volume42
Issue number2
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Head inducer
  • Homeobox
  • Orthodenticle
  • Xenopus laevis
  • Xotx2

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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