Cl--dependent HCO3- transport by cystic fibrosis transmembrane conductance regulator

Joo Young Choi, Min Goo Lee, Shigeru Ko, Shmuel Muallem

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cystic fibrosis (CF) affects the function of multiple organs. The inability to maintain luminal hydration of ducts leads to their plugging and destruction of the affected organs. An exacerbating problem is the acidic pH of the fluid produced by CF patients' secretory glands. This is best documented for pancreatic secretion. Alkaline fluid secretion requires vectorial transport of electrolytes and of HCO3 -. The mechanism of HCO3- secretion by cystic fibrosis transmembrane conductance regulator (CFTR) expressing cells is not well understood. In the present communication we discuss results suggesting that CFTR itself can transport large amounts of HCO3- and that HCO3- transport by CFTR is mediated by a coupled, Cl--dependent process that is different from a simple HCO3- conductance.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalJournal of the Pancreas
Volume2
Issue number4
Publication statusPublished - 2001 Jul 1
Externally publishedYes

Keywords

  • Bicarbonates
  • Cystic fibrosis transmembrane conductance
  • Ion transport
  • Pancreatic ducts
  • Pancreatic juice

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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    Choi, J. Y., Lee, M. G., Ko, S., & Muallem, S. (2001). Cl--dependent HCO3- transport by cystic fibrosis transmembrane conductance regulator. Journal of the Pancreas, 2(4), 243-246.