Abstract
Recent studies documented that most centenarians were survivors with multiple comorbidities. We examined morbidities and physical and cognitive function of 302 Japanese centenarians living in Tokyo, and assessed the association between morbidities and functional status. Most centenarians have chronic diseases such as hypertension, heart disease, and stroke. Notably, the prevalence of diabetes mellitus was very low compared with middle-aged Japanese adults. Stroke and fracture were significantly associated with poorer physical and cognitive function. Higher blood pressure, higher serum total cholesterol concentration and higher serum high-density lipoprotein cholesterol concentration were associated with better physical and cognitive function. It seems that the oldest-old might be less affected with conventional risk factors, such as hypertension and hypercholesterolemia, at least in terms of functional status. This phenomenon might be one of the "centenarian paradox".
| Original language | English |
|---|---|
| Pages (from-to) | 1343-1347 |
| Number of pages | 5 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 67 |
| Issue number | 7 |
| Publication status | Published - 2009 Jul |
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ASJC Scopus subject areas
- Medicine(all)
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Clues to the exceptional longevity --morbiditiy and functional status of Tokyo-area centenarians. / Takayama, Michiyo; Hirose, Nobuyoshi.
In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 67, No. 7, 07.2009, p. 1343-1347.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clues to the exceptional longevity --morbiditiy and functional status of Tokyo-area centenarians
AU - Takayama, Michiyo
AU - Hirose, Nobuyoshi
PY - 2009/7
Y1 - 2009/7
N2 - Recent studies documented that most centenarians were survivors with multiple comorbidities. We examined morbidities and physical and cognitive function of 302 Japanese centenarians living in Tokyo, and assessed the association between morbidities and functional status. Most centenarians have chronic diseases such as hypertension, heart disease, and stroke. Notably, the prevalence of diabetes mellitus was very low compared with middle-aged Japanese adults. Stroke and fracture were significantly associated with poorer physical and cognitive function. Higher blood pressure, higher serum total cholesterol concentration and higher serum high-density lipoprotein cholesterol concentration were associated with better physical and cognitive function. It seems that the oldest-old might be less affected with conventional risk factors, such as hypertension and hypercholesterolemia, at least in terms of functional status. This phenomenon might be one of the "centenarian paradox".
AB - Recent studies documented that most centenarians were survivors with multiple comorbidities. We examined morbidities and physical and cognitive function of 302 Japanese centenarians living in Tokyo, and assessed the association between morbidities and functional status. Most centenarians have chronic diseases such as hypertension, heart disease, and stroke. Notably, the prevalence of diabetes mellitus was very low compared with middle-aged Japanese adults. Stroke and fracture were significantly associated with poorer physical and cognitive function. Higher blood pressure, higher serum total cholesterol concentration and higher serum high-density lipoprotein cholesterol concentration were associated with better physical and cognitive function. It seems that the oldest-old might be less affected with conventional risk factors, such as hypertension and hypercholesterolemia, at least in terms of functional status. This phenomenon might be one of the "centenarian paradox".
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M3 - Article
C2 - 19591283
AN - SCOPUS:69849097504
VL - 67
SP - 1343
EP - 1347
JO - Nihon rinsho. Japanese journal of clinical medicine
JF - Nihon rinsho. Japanese journal of clinical medicine
SN - 0047-1852
IS - 7
ER -