Abstract
Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.
| Original language | English |
|---|---|
| Pages (from-to) | 640-644 |
| Number of pages | 5 |
| Journal | Neuropathology |
| Volume | 28 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2008 Dec 1 |
| Externally published | Yes |
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Keywords
- Central nervous system
- Gene rearrangement
- Lymph node involvement
- Lymphomatoid granulomatosis
- Malignant potential
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology
Cite this
CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements. / Takiyama, Akihiro; Nishihara, Hiroshi; Tateishi, Ukihide; Kimura, Taichi; Lei, Wang; Marukawa, Katsuji; Itoh, Tomoo; Hashino, Satoshi; Nagashima, Kazuo; Tanaka, Shinya.
In: Neuropathology, Vol. 28, No. 6, 01.12.2008, p. 640-644.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements
AU - Takiyama, Akihiro
AU - Nishihara, Hiroshi
AU - Tateishi, Ukihide
AU - Kimura, Taichi
AU - Lei, Wang
AU - Marukawa, Katsuji
AU - Itoh, Tomoo
AU - Hashino, Satoshi
AU - Nagashima, Kazuo
AU - Tanaka, Shinya
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.
AB - Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.
KW - Central nervous system
KW - Gene rearrangement
KW - Lymph node involvement
KW - Lymphomatoid granulomatosis
KW - Malignant potential
UR - http://www.scopus.com/inward/record.url?scp=54849416363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54849416363&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1789.2008.00903.x
DO - 10.1111/j.1440-1789.2008.00903.x
M3 - Article
C2 - 18410281
AN - SCOPUS:54849416363
VL - 28
SP - 640
EP - 644
JO - Neuropathology
JF - Neuropathology
SN - 0919-6544
IS - 6
ER -