CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements

Akihiro Takiyama; Hiroshi Nishihara; Ukihide Tateishi; Taichi Kimura; Wang Lei; Katsuji Marukawa; Tomoo Itoh; Satoshi Hashino; Kazuo Nagashima; Shinya Tanaka

doi:10.1111/j.1440-1789.2008.00903.x

CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements

Akihiro Takiyama, Hiroshi Nishihara, Ukihide Tateishi, Taichi Kimura, Wang Lei, Katsuji Marukawa, Tomoo Itoh, Satoshi Hashino, Kazuo Nagashima, Shinya Tanaka

Clinical and Translational Research Center

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.

Original language	English
Pages (from-to)	640-644
Number of pages	5
Journal	Neuropathology
Volume	28
Issue number	6
DOIs	https://doi.org/10.1111/j.1440-1789.2008.00903.x
Publication status	Published - 2008 Dec 1

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Keywords

Central nervous system
Gene rearrangement
Lymph node involvement
Lymphomatoid granulomatosis
Malignant potential

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology

Cite this

Takiyama, A., Nishihara, H., Tateishi, U., Kimura, T., Lei, W., Marukawa, K., Itoh, T., Hashino, S., Nagashima, K., & Tanaka, S. (2008). CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements. Neuropathology, 28(6), 640-644. https://doi.org/10.1111/j.1440-1789.2008.00903.x

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abstract = "Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.",

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author = "Akihiro Takiyama and Hiroshi Nishihara and Ukihide Tateishi and Taichi Kimura and Wang Lei and Katsuji Marukawa and Tomoo Itoh and Satoshi Hashino and Kazuo Nagashima and Shinya Tanaka",

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AU - Takiyama, Akihiro

AU - Nishihara, Hiroshi

AU - Tateishi, Ukihide

AU - Kimura, Taichi

AU - Lei, Wang

AU - Marukawa, Katsuji

AU - Itoh, Tomoo

AU - Hashino, Satoshi

AU - Nagashima, Kazuo

AU - Tanaka, Shinya

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N2 - Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.

AB - Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.

KW - Central nervous system

KW - Gene rearrangement

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KW - Lymphomatoid granulomatosis

KW - Malignant potential

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10.1111/j.1440-1789.2008.00903.x