CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements

Akihiro Takiyama, Hiroshi Nishihara, Ukihide Tateishi, Taichi Kimura, Wang Lei, Katsuji Marukawa, Tomoo Itoh, Satoshi Hashino, Kazuo Nagashima, Shinya Tanaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.

Original languageEnglish
Pages (from-to)640-644
Number of pages5
JournalNeuropathology
Volume28
Issue number6
DOIs
Publication statusPublished - 2008 Dec 1
Externally publishedYes

Fingerprint

Lymphomatoid Granulomatosis
Lymph Nodes
Bone Marrow
Groin
Peripheral T-Cell Lymphoma
Gene Rearrangement
Brain
Paraffin
T-Lymphocytes
Biopsy

Keywords

  • Central nervous system
  • Gene rearrangement
  • Lymph node involvement
  • Lymphomatoid granulomatosis
  • Malignant potential

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Takiyama, A., Nishihara, H., Tateishi, U., Kimura, T., Lei, W., Marukawa, K., ... Tanaka, S. (2008). CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements. Neuropathology, 28(6), 640-644. https://doi.org/10.1111/j.1440-1789.2008.00903.x

CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements. / Takiyama, Akihiro; Nishihara, Hiroshi; Tateishi, Ukihide; Kimura, Taichi; Lei, Wang; Marukawa, Katsuji; Itoh, Tomoo; Hashino, Satoshi; Nagashima, Kazuo; Tanaka, Shinya.

In: Neuropathology, Vol. 28, No. 6, 01.12.2008, p. 640-644.

Research output: Contribution to journalArticle

Takiyama, A, Nishihara, H, Tateishi, U, Kimura, T, Lei, W, Marukawa, K, Itoh, T, Hashino, S, Nagashima, K & Tanaka, S 2008, 'CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements', Neuropathology, vol. 28, no. 6, pp. 640-644. https://doi.org/10.1111/j.1440-1789.2008.00903.x
Takiyama, Akihiro ; Nishihara, Hiroshi ; Tateishi, Ukihide ; Kimura, Taichi ; Lei, Wang ; Marukawa, Katsuji ; Itoh, Tomoo ; Hashino, Satoshi ; Nagashima, Kazuo ; Tanaka, Shinya. / CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements. In: Neuropathology. 2008 ; Vol. 28, No. 6. pp. 640-644.
@article{ec24aaa2b59d43989f014d004e9172f1,
title = "CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements",
abstract = "Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.",
keywords = "Central nervous system, Gene rearrangement, Lymph node involvement, Lymphomatoid granulomatosis, Malignant potential",
author = "Akihiro Takiyama and Hiroshi Nishihara and Ukihide Tateishi and Taichi Kimura and Wang Lei and Katsuji Marukawa and Tomoo Itoh and Satoshi Hashino and Kazuo Nagashima and Shinya Tanaka",
year = "2008",
month = "12",
day = "1",
doi = "10.1111/j.1440-1789.2008.00903.x",
language = "English",
volume = "28",
pages = "640--644",
journal = "Neuropathology",
issn = "0919-6544",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements

AU - Takiyama, Akihiro

AU - Nishihara, Hiroshi

AU - Tateishi, Ukihide

AU - Kimura, Taichi

AU - Lei, Wang

AU - Marukawa, Katsuji

AU - Itoh, Tomoo

AU - Hashino, Satoshi

AU - Nagashima, Kazuo

AU - Tanaka, Shinya

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.

AB - Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.

KW - Central nervous system

KW - Gene rearrangement

KW - Lymph node involvement

KW - Lymphomatoid granulomatosis

KW - Malignant potential

UR - http://www.scopus.com/inward/record.url?scp=54849416363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54849416363&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1789.2008.00903.x

DO - 10.1111/j.1440-1789.2008.00903.x

M3 - Article

C2 - 18410281

AN - SCOPUS:54849416363

VL - 28

SP - 640

EP - 644

JO - Neuropathology

JF - Neuropathology

SN - 0919-6544

IS - 6

ER -