Abstract
Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRγ-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.
Original language | English |
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Pages (from-to) | 640-644 |
Number of pages | 5 |
Journal | Neuropathology |
Volume | 28 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2008 Dec |
Externally published | Yes |
Keywords
- Central nervous system
- Gene rearrangement
- Lymph node involvement
- Lymphomatoid granulomatosis
- Malignant potential
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology