Abstract
The reductive carboxylation of α,β-unsaturated carbonyl compounds with carbon dioxide was studied. After the screening of various transition-metal complex catalysts and reducing agents, it was found that the combination of bis(acetylacetonato) cobalt(II) and diethylzinc could effectively afford the corresponding α-carboxylate in high yield from α,β-unsaturated nitriles. The product was obtained after esterification by trimethylsilyldiazomethane. The highly selective carboxylation was observed at the β-position in the present study.
| Original language | English |
|---|---|
| Pages (from-to) | 565-567 |
| Number of pages | 3 |
| Journal | Chemistry Letters |
| Volume | 43 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Cobalt-catalyzed reductive carboxylation on α,β-unsaturated nitriles with carbon dioxide. / Hayashi, Chika; Hayashi, Takuo; Kikuchi, Satoshi; Yamada, Tohru.
In: Chemistry Letters, Vol. 43, No. 4, 2014, p. 565-567.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cobalt-catalyzed reductive carboxylation on α,β-unsaturated nitriles with carbon dioxide
AU - Hayashi, Chika
AU - Hayashi, Takuo
AU - Kikuchi, Satoshi
AU - Yamada, Tohru
PY - 2014
Y1 - 2014
N2 - The reductive carboxylation of α,β-unsaturated carbonyl compounds with carbon dioxide was studied. After the screening of various transition-metal complex catalysts and reducing agents, it was found that the combination of bis(acetylacetonato) cobalt(II) and diethylzinc could effectively afford the corresponding α-carboxylate in high yield from α,β-unsaturated nitriles. The product was obtained after esterification by trimethylsilyldiazomethane. The highly selective carboxylation was observed at the β-position in the present study.
AB - The reductive carboxylation of α,β-unsaturated carbonyl compounds with carbon dioxide was studied. After the screening of various transition-metal complex catalysts and reducing agents, it was found that the combination of bis(acetylacetonato) cobalt(II) and diethylzinc could effectively afford the corresponding α-carboxylate in high yield from α,β-unsaturated nitriles. The product was obtained after esterification by trimethylsilyldiazomethane. The highly selective carboxylation was observed at the β-position in the present study.
UR - http://www.scopus.com/inward/record.url?scp=84897481492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897481492&partnerID=8YFLogxK
U2 - 10.1246/cl.131163
DO - 10.1246/cl.131163
M3 - Article
AN - SCOPUS:84897481492
VL - 43
SP - 565
EP - 567
JO - Chemistry Letters
JF - Chemistry Letters
SN - 0366-7022
IS - 4
ER -