Cobalt-catalyzed reductive carboxylation on α,β-unsaturated nitriles with carbon dioxide

Chika Hayashi, Takuo Hayashi, Satoshi Kikuchi, Tohru Yamada

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The reductive carboxylation of α,β-unsaturated carbonyl compounds with carbon dioxide was studied. After the screening of various transition-metal complex catalysts and reducing agents, it was found that the combination of bis(acetylacetonato) cobalt(II) and diethylzinc could effectively afford the corresponding α-carboxylate in high yield from α,β-unsaturated nitriles. The product was obtained after esterification by trimethylsilyldiazomethane. The highly selective carboxylation was observed at the β-position in the present study.

Original languageEnglish
Pages (from-to)565-567
Number of pages3
JournalChemistry Letters
Volume43
Issue number4
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Chemistry(all)

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