Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases

M. Hirakata, M. Akizuki, K. Miyachi, H. Matsushima, T. Okano, M. Homma

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Two patients with characteristic features of CREST syndrome and primary biliary cirrhosis are reported. Sera of both patients contained autoantibodies to centromere and mitochondrial antigens. Immunodiffusion analysis identified the specificities of precipitating antibodies of mitochondria of the first case as anti-M-A and M-C, and of the second case as anti-M-A and M-B antibodies. Simultaneous occurrence of 2 marker antibodies in an individual patient indicates that the 2 patients reported here have CREST syndrome and primary biliary cirrhosis, both of which are considered as a distinct clinical entity.

Original languageEnglish
Pages (from-to)1166-1170
Number of pages5
JournalJournal of Rheumatology
Volume15
Issue number7
Publication statusPublished - 1988 Jan 1

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases'. Together they form a unique fingerprint.

  • Cite this

    Hirakata, M., Akizuki, M., Miyachi, K., Matsushima, H., Okano, T., & Homma, M. (1988). Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases. Journal of Rheumatology, 15(7), 1166-1170.