Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases

Michito Hirakata, M. Akizuki, K. Miyachi, H. Matsushima, T. Okano, M. Homma

Research output: Contribution to journalArticle

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Abstract

Two patients with characteristic features of CREST syndrome and primary biliary cirrhosis are reported. Sera of both patients contained autoantibodies to centromere and mitochondrial antigens. Immunodiffusion analysis identified the specificities of precipitating antibodies of mitochondria of the first case as anti-M-A and M-C, and of the second case as anti-M-A and M-B antibodies. Simultaneous occurrence of 2 marker antibodies in an individual patient indicates that the 2 patients reported here have CREST syndrome and primary biliary cirrhosis, both of which are considered as a distinct clinical entity.

Original languageEnglish
Pages (from-to)1166-1170
Number of pages5
JournalJournal of Rheumatology
Volume15
Issue number7
Publication statusPublished - 1988

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CREST Syndrome
Biliary Liver Cirrhosis
Antibody Specificity
Antibodies
Centromere
Immunodiffusion
Autoantibodies
Mitochondria
Antigens
Serum

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Hirakata, M., Akizuki, M., Miyachi, K., Matsushima, H., Okano, T., & Homma, M. (1988). Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases. Journal of Rheumatology, 15(7), 1166-1170.

Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases. / Hirakata, Michito; Akizuki, M.; Miyachi, K.; Matsushima, H.; Okano, T.; Homma, M.

In: Journal of Rheumatology, Vol. 15, No. 7, 1988, p. 1166-1170.

Research output: Contribution to journalArticle

Hirakata, M, Akizuki, M, Miyachi, K, Matsushima, H, Okano, T & Homma, M 1988, 'Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases', Journal of Rheumatology, vol. 15, no. 7, pp. 1166-1170.
Hirakata, Michito ; Akizuki, M. ; Miyachi, K. ; Matsushima, H. ; Okano, T. ; Homma, M. / Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases. In: Journal of Rheumatology. 1988 ; Vol. 15, No. 7. pp. 1166-1170.
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