TY - JOUR
T1 - Coexistence of psoriasis and linear IgA bullous dermatosis
AU - Takagi, Yuko
AU - Sawada, S.
AU - Yamauchi, M.
AU - Amagai, M.
AU - Niimura, M.
PY - 2000
Y1 - 2000
N2 - Linear IgA bullous dermatosis (LABD) is characterized by IgA autoantibodies against components of the basement membrane zone (BMZ). A 97- kDa protein is one of the major autoantigens associated with this disease. We report a 68-year-old man who developed LABD after a 3-year history of psoriasis and in the context of active hepatitis C virus infection. He had been treated with cyclosporin for psoriasis for about 9 months. Histologically, there was a subepidermal blister containing neutrophils and eosinophils with lymphocytes infiltrating predominantly in the dermis. Direct immunofluorescent staining showed linear IgA deposition at the BMZ. The patient's IgA autoantibodies bound exclusively to the epidermal side of 1 mol/L salt-split normal human skin. Immunoblot analysis identified a 97-kDa autoantigen in epidermal extracts. This appears to be the first case of LABD with IgA autoantibodies against a 97-kDa autoantigen, associated with psoriasis and hepatitis C virus infection.
AB - Linear IgA bullous dermatosis (LABD) is characterized by IgA autoantibodies against components of the basement membrane zone (BMZ). A 97- kDa protein is one of the major autoantigens associated with this disease. We report a 68-year-old man who developed LABD after a 3-year history of psoriasis and in the context of active hepatitis C virus infection. He had been treated with cyclosporin for psoriasis for about 9 months. Histologically, there was a subepidermal blister containing neutrophils and eosinophils with lymphocytes infiltrating predominantly in the dermis. Direct immunofluorescent staining showed linear IgA deposition at the BMZ. The patient's IgA autoantibodies bound exclusively to the epidermal side of 1 mol/L salt-split normal human skin. Immunoblot analysis identified a 97-kDa autoantigen in epidermal extracts. This appears to be the first case of LABD with IgA autoantibodies against a 97-kDa autoantigen, associated with psoriasis and hepatitis C virus infection.
KW - 97-kDa epidermal antigen
KW - Hepatitis C virus infection
KW - Linear IgA bullous dermatosis
KW - Psoriasis
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U2 - 10.1046/j.1365-2133.2000.03367.x
DO - 10.1046/j.1365-2133.2000.03367.x
M3 - Article
C2 - 10735961
AN - SCOPUS:0034057460
SN - 0007-0963
VL - 142
SP - 513
EP - 516
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 3
ER -
