Coffee induces vascular endothelial growth factor (VEGF) expression in human neuroblastama SH-SY5Y cells

Shota Kakio, Megumi Tago, Kenji Kobata, Hiroomi Tamura

Research output: Contribution to journalArticle

2 Citations (Scopus)


Recent evidence indicates that hypoxia-inducible vascular endothelial growth factor (VEGF) has neurotrophic and neuroprotective effects on neuronal and glial cells. On the other hand, recent epidemiological studies showed that daily coffee consumption has been associated with a lower risk of several neuronal disorders. Therefore, we investigated the effect of coffee on VEGF expression in human neuroblastoma SH-SY5Y cells. We found that even low concentration of coffee (

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalNutritional Neuroscience
Publication statusAccepted/In press - 2016 Jan 21



  • Coffee
  • HIF-1a
  • Neurodegeneration
  • SH-SY5Y
  • VEGF

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Neuroscience(all)

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