Cognitive dysfunction in systemic lupus erythematosus

Asako Emori, Eisuke Matsushima, Okihiko Aihara, Katsuya Ohta, Ryuji Koike, Nobuyuki Miyasaka, Motoichiro Kato

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune-mediated collagen disease that results in multiorgan failure. It is the collagen disease most frequently associated with neuropsychiatrie symptoms, which have been hypothesized to stem from certain types of cognitive dysfunction. Subjects were 21 patients with SLE (one man, 20 women; aged 16-55 years; mean age, 35.1 ± 10.7 years) who were undergoing treatment in the rheumatology unit of a general hospital, and 17 healthy control subjects matched to the patient group with respect to age and gender (two men, 15 women; mean age, 35.9 ± 6.3 years). They were administered various tests of cognitive function including verbal reasoning, non-verbal reasoning, verbal memory, non-verbal memory, attention and mental flexibility, psychomotor speed and frontal lobe function. In addition, the SLE patients were tested for antiphospholipid antibodies. The SLE patients performed worse than the control group on immediate, delayed and interference of the Rey verbal test and paired associate tests of Wechsler Memory Scale, and their reaction time was slower in Trail A and Trail B tests. Moreover, these findings were more pronounced in the group with major neuropsychiatrie symptoms. However, no relationship was apparent between these deficits in cognitive function and the presence or absence of antiphospholipid antibodies. The results suggest that verbal memory and psychomotor speed underlie the neuropsychiatric symptoms seen in SLE patients.

Original languageEnglish
Pages (from-to)584-589
Number of pages6
JournalPsychiatry and Clinical Neurosciences
Volume59
Issue number5
DOIs
Publication statusPublished - 2005 Oct

Fingerprint

Systemic Lupus Erythematosus
Collagen Diseases
Antiphospholipid Antibodies
Cognition
Wechsler Scales
Rheumatology
Frontal Lobe
General Hospitals
Reaction Time
Healthy Volunteers
Cognitive Dysfunction
Control Groups
Therapeutics

Keywords

  • Cognitive dysfunction
  • Neuropsychiatric symptom
  • Psychomotor speed
  • Systemic lupus erythematosus
  • Verbal memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Emori, A., Matsushima, E., Aihara, O., Ohta, K., Koike, R., Miyasaka, N., & Kato, M. (2005). Cognitive dysfunction in systemic lupus erythematosus. Psychiatry and Clinical Neurosciences, 59(5), 584-589. https://doi.org/10.1111/j.1440-1819.2005.01418.x

Cognitive dysfunction in systemic lupus erythematosus. / Emori, Asako; Matsushima, Eisuke; Aihara, Okihiko; Ohta, Katsuya; Koike, Ryuji; Miyasaka, Nobuyuki; Kato, Motoichiro.

In: Psychiatry and Clinical Neurosciences, Vol. 59, No. 5, 10.2005, p. 584-589.

Research output: Contribution to journalArticle

Emori, A, Matsushima, E, Aihara, O, Ohta, K, Koike, R, Miyasaka, N & Kato, M 2005, 'Cognitive dysfunction in systemic lupus erythematosus', Psychiatry and Clinical Neurosciences, vol. 59, no. 5, pp. 584-589. https://doi.org/10.1111/j.1440-1819.2005.01418.x
Emori A, Matsushima E, Aihara O, Ohta K, Koike R, Miyasaka N et al. Cognitive dysfunction in systemic lupus erythematosus. Psychiatry and Clinical Neurosciences. 2005 Oct;59(5):584-589. https://doi.org/10.1111/j.1440-1819.2005.01418.x
Emori, Asako ; Matsushima, Eisuke ; Aihara, Okihiko ; Ohta, Katsuya ; Koike, Ryuji ; Miyasaka, Nobuyuki ; Kato, Motoichiro. / Cognitive dysfunction in systemic lupus erythematosus. In: Psychiatry and Clinical Neurosciences. 2005 ; Vol. 59, No. 5. pp. 584-589.
@article{0b3b10d92ac74b61bc35a95ec1224a8d,
title = "Cognitive dysfunction in systemic lupus erythematosus",
abstract = "Systemic lupus erythematosus (SLE) is an autoimmune-mediated collagen disease that results in multiorgan failure. It is the collagen disease most frequently associated with neuropsychiatrie symptoms, which have been hypothesized to stem from certain types of cognitive dysfunction. Subjects were 21 patients with SLE (one man, 20 women; aged 16-55 years; mean age, 35.1 ± 10.7 years) who were undergoing treatment in the rheumatology unit of a general hospital, and 17 healthy control subjects matched to the patient group with respect to age and gender (two men, 15 women; mean age, 35.9 ± 6.3 years). They were administered various tests of cognitive function including verbal reasoning, non-verbal reasoning, verbal memory, non-verbal memory, attention and mental flexibility, psychomotor speed and frontal lobe function. In addition, the SLE patients were tested for antiphospholipid antibodies. The SLE patients performed worse than the control group on immediate, delayed and interference of the Rey verbal test and paired associate tests of Wechsler Memory Scale, and their reaction time was slower in Trail A and Trail B tests. Moreover, these findings were more pronounced in the group with major neuropsychiatrie symptoms. However, no relationship was apparent between these deficits in cognitive function and the presence or absence of antiphospholipid antibodies. The results suggest that verbal memory and psychomotor speed underlie the neuropsychiatric symptoms seen in SLE patients.",
keywords = "Cognitive dysfunction, Neuropsychiatric symptom, Psychomotor speed, Systemic lupus erythematosus, Verbal memory",
author = "Asako Emori and Eisuke Matsushima and Okihiko Aihara and Katsuya Ohta and Ryuji Koike and Nobuyuki Miyasaka and Motoichiro Kato",
year = "2005",
month = "10",
doi = "10.1111/j.1440-1819.2005.01418.x",
language = "English",
volume = "59",
pages = "584--589",
journal = "Psychiatry and Clinical Neurosciences",
issn = "1323-1316",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Cognitive dysfunction in systemic lupus erythematosus

AU - Emori, Asako

AU - Matsushima, Eisuke

AU - Aihara, Okihiko

AU - Ohta, Katsuya

AU - Koike, Ryuji

AU - Miyasaka, Nobuyuki

AU - Kato, Motoichiro

PY - 2005/10

Y1 - 2005/10

N2 - Systemic lupus erythematosus (SLE) is an autoimmune-mediated collagen disease that results in multiorgan failure. It is the collagen disease most frequently associated with neuropsychiatrie symptoms, which have been hypothesized to stem from certain types of cognitive dysfunction. Subjects were 21 patients with SLE (one man, 20 women; aged 16-55 years; mean age, 35.1 ± 10.7 years) who were undergoing treatment in the rheumatology unit of a general hospital, and 17 healthy control subjects matched to the patient group with respect to age and gender (two men, 15 women; mean age, 35.9 ± 6.3 years). They were administered various tests of cognitive function including verbal reasoning, non-verbal reasoning, verbal memory, non-verbal memory, attention and mental flexibility, psychomotor speed and frontal lobe function. In addition, the SLE patients were tested for antiphospholipid antibodies. The SLE patients performed worse than the control group on immediate, delayed and interference of the Rey verbal test and paired associate tests of Wechsler Memory Scale, and their reaction time was slower in Trail A and Trail B tests. Moreover, these findings were more pronounced in the group with major neuropsychiatrie symptoms. However, no relationship was apparent between these deficits in cognitive function and the presence or absence of antiphospholipid antibodies. The results suggest that verbal memory and psychomotor speed underlie the neuropsychiatric symptoms seen in SLE patients.

AB - Systemic lupus erythematosus (SLE) is an autoimmune-mediated collagen disease that results in multiorgan failure. It is the collagen disease most frequently associated with neuropsychiatrie symptoms, which have been hypothesized to stem from certain types of cognitive dysfunction. Subjects were 21 patients with SLE (one man, 20 women; aged 16-55 years; mean age, 35.1 ± 10.7 years) who were undergoing treatment in the rheumatology unit of a general hospital, and 17 healthy control subjects matched to the patient group with respect to age and gender (two men, 15 women; mean age, 35.9 ± 6.3 years). They were administered various tests of cognitive function including verbal reasoning, non-verbal reasoning, verbal memory, non-verbal memory, attention and mental flexibility, psychomotor speed and frontal lobe function. In addition, the SLE patients were tested for antiphospholipid antibodies. The SLE patients performed worse than the control group on immediate, delayed and interference of the Rey verbal test and paired associate tests of Wechsler Memory Scale, and their reaction time was slower in Trail A and Trail B tests. Moreover, these findings were more pronounced in the group with major neuropsychiatrie symptoms. However, no relationship was apparent between these deficits in cognitive function and the presence or absence of antiphospholipid antibodies. The results suggest that verbal memory and psychomotor speed underlie the neuropsychiatric symptoms seen in SLE patients.

KW - Cognitive dysfunction

KW - Neuropsychiatric symptom

KW - Psychomotor speed

KW - Systemic lupus erythematosus

KW - Verbal memory

UR - http://www.scopus.com/inward/record.url?scp=28844474967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28844474967&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1819.2005.01418.x

DO - 10.1111/j.1440-1819.2005.01418.x

M3 - Article

C2 - 16194262

AN - SCOPUS:28844474967

VL - 59

SP - 584

EP - 589

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

SN - 1323-1316

IS - 5

ER -