TY - JOUR
T1 - Cohort profile
T2 - Patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation - Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF)
AU - Ikemura, Nobuhiro
AU - Spertus, John A.
AU - Kimura, Takehiro
AU - Mahaffey, Kenneth
AU - Piccini, Jonathan P.
AU - Inohara, Taku
AU - Ueda, Ikuko
AU - Tanimoto, Kojiro
AU - Suzuki, Masahiro
AU - Nakamura, Iwao
AU - Akaishi, Makoto
AU - Mitamura, Hideo
AU - Fukuda, Keiichi
AU - Takatsuki, Seiji
AU - Kohsaka, Shun
N1 - Funding Information:
This study was funded by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (grant no. 16H05215, 16KK0186) and by an unrestricted research grant from Bayer Yakuhin Ltd.
Funding Information:
Competing interests SK received an unrestricted research grant for the Department of Cardiology at Keio University School of Medicine from Bayer Pharmaceutical and Daiichi Sankyo; reported receiving grants from Bayer Yakuhin Ltd and Daiichi Sankyo; and reported receiving personal fees from Bristol-Myers Squibb. TK received grants from Bayer Yakuhin Ltd. JS received personal fees from Novartis, AstraZeneca, Janssen, Bayer, Boehringer Ingelheim, Regeneron, Corvia and United Healthcare; reported receiving grants from Bayer and Abbott Vascular; and reported owning equity in Health Outcomes Sciences. ST received grants and personal fees from Bayer and reported receiving personal fees from Daiichi Sankyo and Bristol-Myers Squibb.
Funding Information:
Collaborators Site investigators: Munehisa Sakamoto, Jun Fuse, Kojiro Tanimoto, Yoko Tanimoto, Yukinori Ikegami, Kohei Inagawa (National Hospital Organization Tokyo Medical Center). Jyunji Suzuki, Tomohiro Matsuhashi, Hiroshi Shiga (Hino Municipal Hospital). Yoshiyasu Aizawa, Nobuhiro Nishiyama, Takahiko Nishiyama, Yoshinori Katsumata, Shin Kashimura, Akira Kunitomi, Kazuaki Nakajima, Taishi Fujisawa (Keio University School of Medicine). Takaharu Katayama, Keisuke Matsumura, Tomohiko Ono, Hanako Tokuda, Ryutaro Yamaguchi, Hiroaki Tanaka (National Hospital Organization Saitama National Hospital). Takashi Yagi, Kenichiro Shimoji, Koji Ueno, Satoshi Mogi (Saiseikai Utsunomiya Hospital). Shiro Ishikawa, Hideaki Kanki, Takashi Akima, Masahito Munakata, Kazutaka Miyamoto (Saitama City Hospital). Kazunori Moritani, Masaru Shibata, Toshimi Kageyama (Tachikawa Hospital). Akiyasu Baba, Yoshinori Mano, Hiroaki Sukegawa (Tokyo Dental College Ichikawa General Hospital). Takahiro Koura, Daisuke Shinmura, Kotaro Fukumoto, Hiroyuki Yamakawa (Yokohama Municipal Citizen’s Hospital). Kazuhiro Oyamada, Kotaro Naitou, Keijiro Chiba (Keiyu Hospital). Clinical co-ordinators: Aki Kato, Ikumi Koishi, Miho Matsuoka, Takako Nozaki, Hiroaki Nagayama, Chieko Tamura, Reiko Tamura, Junko Susa, Miho Umemura and Itsuka Saito. Contributors NI, SK and TK had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. IU, KT, MS, IN, MA and HM contributed substantially to data collection. NI, JAS, TK, KM, JPP, TI, KF, ST and SK contributed substantially to the study design, data analysis, data interpretation and the writing of the manuscript. Funding This study was funded by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (grant no. 16H05215, 16KK0186) and by an unrestricted research grant from Bayer Yakuhin Ltd. map disclaimer The depiction of boundaries on this map does not imply the expression of any opinion whatsoever on the part of BMJ (or any member of its group) concerning the legal status of any country, territory, jurisdiction or area or of its authorities. This map is provided without any warranty of any kind, either express or implied.
Publisher Copyright:
© 2019 Author(s).
PY - 2019/12/18
Y1 - 2019/12/18
N2 - Purpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) registry is to clarify the baseline and QOL profiles of the AF patients at the time of initial referral to identify areas for improvement and country-specific gaps. Participants: The KiCS-AF registry is a multicentre, prospective cohort study designed to specifically recruit AF patients newly referred to the 11 network hospitals within the Kanto area of Japan. The registry completed its enrolment in June 2018. All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. The registry also assessed individual treatment strategies including rate and rhythm control, stroke prophylaxis, and their impacts on patient-reported QOL. Findings to date: As of December 2016, 2464 AF patients were registered; their mean age was 67.1 years (SD, 11.7), majority (69.7%; n=1717) were men and 49.2% presented with paroxysmal AF. The mean CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age ≥75 years, diabetes, stroke including vascular disease, age 65-74 years, and sex category [female]) score was 2.3 (SD, 1.6) and oral anticoagulant therapy was used for 88.6% of patients with CHA2DS2-VASc scores ≥2. The median AFEQT-overall summary score was 79.1 (IQR, 66.6-89.1). Roughly 50% had significantly impaired QOL (ie, AFEQT <80) at baseline. Currently, 2307 eligible patients (93.6%) have completed the 1-year follow-up, of which 2072 patients (89.8%) answered the second AFEQT questionnaire. Future plans The KiCS-AF allowed for extensive investigation of AF-related QOL in a non-selected population with long-term follow-up using a rigorously validated QOL assessment tool. Almost half of patients had impaired QOL at baseline. Further investigations aimed at providing care and improving patient-reported QOL are required.
AB - Purpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) registry is to clarify the baseline and QOL profiles of the AF patients at the time of initial referral to identify areas for improvement and country-specific gaps. Participants: The KiCS-AF registry is a multicentre, prospective cohort study designed to specifically recruit AF patients newly referred to the 11 network hospitals within the Kanto area of Japan. The registry completed its enrolment in June 2018. All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. The registry also assessed individual treatment strategies including rate and rhythm control, stroke prophylaxis, and their impacts on patient-reported QOL. Findings to date: As of December 2016, 2464 AF patients were registered; their mean age was 67.1 years (SD, 11.7), majority (69.7%; n=1717) were men and 49.2% presented with paroxysmal AF. The mean CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age ≥75 years, diabetes, stroke including vascular disease, age 65-74 years, and sex category [female]) score was 2.3 (SD, 1.6) and oral anticoagulant therapy was used for 88.6% of patients with CHA2DS2-VASc scores ≥2. The median AFEQT-overall summary score was 79.1 (IQR, 66.6-89.1). Roughly 50% had significantly impaired QOL (ie, AFEQT <80) at baseline. Currently, 2307 eligible patients (93.6%) have completed the 1-year follow-up, of which 2072 patients (89.8%) answered the second AFEQT questionnaire. Future plans The KiCS-AF allowed for extensive investigation of AF-related QOL in a non-selected population with long-term follow-up using a rigorously validated QOL assessment tool. Almost half of patients had impaired QOL at baseline. Further investigations aimed at providing care and improving patient-reported QOL are required.
KW - adult cardiology
KW - pacing & electrophysiology
KW - quality in health care
UR - http://www.scopus.com/inward/record.url?scp=85077047774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077047774&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2019-032746
DO - 10.1136/bmjopen-2019-032746
M3 - Article
C2 - 31857312
AN - SCOPUS:85077047774
VL - 9
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 12
M1 - e032746
ER -