Abstract
Purpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) registry is to clarify the baseline and QOL profiles of the AF patients at the time of initial referral to identify areas for improvement and country-specific gaps. Participants: The KiCS-AF registry is a multicentre, prospective cohort study designed to specifically recruit AF patients newly referred to the 11 network hospitals within the Kanto area of Japan. The registry completed its enrolment in June 2018. All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. The registry also assessed individual treatment strategies including rate and rhythm control, stroke prophylaxis, and their impacts on patient-reported QOL. Findings to date: As of December 2016, 2464 AF patients were registered; their mean age was 67.1 years (SD, 11.7), majority (69.7%; n=1717) were men and 49.2% presented with paroxysmal AF. The mean CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age ≥75 years, diabetes, stroke including vascular disease, age 65-74 years, and sex category [female]) score was 2.3 (SD, 1.6) and oral anticoagulant therapy was used for 88.6% of patients with CHA2DS2-VASc scores ≥2. The median AFEQT-overall summary score was 79.1 (IQR, 66.6-89.1). Roughly 50% had significantly impaired QOL (ie, AFEQT <80) at baseline. Currently, 2307 eligible patients (93.6%) have completed the 1-year follow-up, of which 2072 patients (89.8%) answered the second AFEQT questionnaire. Future plans The KiCS-AF allowed for extensive investigation of AF-related QOL in a non-selected population with long-term follow-up using a rigorously validated QOL assessment tool. Almost half of patients had impaired QOL at baseline. Further investigations aimed at providing care and improving patient-reported QOL are required.
| Original language | English |
|---|---|
| Article number | e032746 |
| Journal | BMJ open |
| Volume | 9 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2019 Dec 18 |
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Keywords
- adult cardiology
- pacing & electrophysiology
- quality in health care
ASJC Scopus subject areas
- Medicine(all)
Cite this
Cohort profile : Patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation - Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF). / Ikemura, Nobuhiro; Spertus, John A.; Kimura, Takehiro; Mahaffey, Kenneth; Piccini, Jonathan P.; Inohara, Taku; Ueda, Ikuko; Tanimoto, Kojiro; Suzuki, Masahiro; Nakamura, Iwao; Akaishi, Makoto; Mitamura, Hideo; Fukuda, Keiichi; Takatsuki, Seiji; Kohsaka, Shun.
In: BMJ open, Vol. 9, No. 12, e032746, 18.12.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cohort profile
T2 - Patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation - Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF)
AU - Ikemura, Nobuhiro
AU - Spertus, John A.
AU - Kimura, Takehiro
AU - Mahaffey, Kenneth
AU - Piccini, Jonathan P.
AU - Inohara, Taku
AU - Ueda, Ikuko
AU - Tanimoto, Kojiro
AU - Suzuki, Masahiro
AU - Nakamura, Iwao
AU - Akaishi, Makoto
AU - Mitamura, Hideo
AU - Fukuda, Keiichi
AU - Takatsuki, Seiji
AU - Kohsaka, Shun
PY - 2019/12/18
Y1 - 2019/12/18
N2 - Purpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) registry is to clarify the baseline and QOL profiles of the AF patients at the time of initial referral to identify areas for improvement and country-specific gaps. Participants: The KiCS-AF registry is a multicentre, prospective cohort study designed to specifically recruit AF patients newly referred to the 11 network hospitals within the Kanto area of Japan. The registry completed its enrolment in June 2018. All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. The registry also assessed individual treatment strategies including rate and rhythm control, stroke prophylaxis, and their impacts on patient-reported QOL. Findings to date: As of December 2016, 2464 AF patients were registered; their mean age was 67.1 years (SD, 11.7), majority (69.7%; n=1717) were men and 49.2% presented with paroxysmal AF. The mean CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age ≥75 years, diabetes, stroke including vascular disease, age 65-74 years, and sex category [female]) score was 2.3 (SD, 1.6) and oral anticoagulant therapy was used for 88.6% of patients with CHA2DS2-VASc scores ≥2. The median AFEQT-overall summary score was 79.1 (IQR, 66.6-89.1). Roughly 50% had significantly impaired QOL (ie, AFEQT <80) at baseline. Currently, 2307 eligible patients (93.6%) have completed the 1-year follow-up, of which 2072 patients (89.8%) answered the second AFEQT questionnaire. Future plans The KiCS-AF allowed for extensive investigation of AF-related QOL in a non-selected population with long-term follow-up using a rigorously validated QOL assessment tool. Almost half of patients had impaired QOL at baseline. Further investigations aimed at providing care and improving patient-reported QOL are required.
AB - Purpose Besides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) registry is to clarify the baseline and QOL profiles of the AF patients at the time of initial referral to identify areas for improvement and country-specific gaps. Participants: The KiCS-AF registry is a multicentre, prospective cohort study designed to specifically recruit AF patients newly referred to the 11 network hospitals within the Kanto area of Japan. The registry completed its enrolment in June 2018. All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. The registry also assessed individual treatment strategies including rate and rhythm control, stroke prophylaxis, and their impacts on patient-reported QOL. Findings to date: As of December 2016, 2464 AF patients were registered; their mean age was 67.1 years (SD, 11.7), majority (69.7%; n=1717) were men and 49.2% presented with paroxysmal AF. The mean CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age ≥75 years, diabetes, stroke including vascular disease, age 65-74 years, and sex category [female]) score was 2.3 (SD, 1.6) and oral anticoagulant therapy was used for 88.6% of patients with CHA2DS2-VASc scores ≥2. The median AFEQT-overall summary score was 79.1 (IQR, 66.6-89.1). Roughly 50% had significantly impaired QOL (ie, AFEQT <80) at baseline. Currently, 2307 eligible patients (93.6%) have completed the 1-year follow-up, of which 2072 patients (89.8%) answered the second AFEQT questionnaire. Future plans The KiCS-AF allowed for extensive investigation of AF-related QOL in a non-selected population with long-term follow-up using a rigorously validated QOL assessment tool. Almost half of patients had impaired QOL at baseline. Further investigations aimed at providing care and improving patient-reported QOL are required.
KW - adult cardiology
KW - pacing & electrophysiology
KW - quality in health care
UR - http://www.scopus.com/inward/record.url?scp=85077047774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077047774&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2019-032746
DO - 10.1136/bmjopen-2019-032746
M3 - Article
C2 - 31857312
AN - SCOPUS:85077047774
VL - 9
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 12
M1 - e032746
ER -