Collagen immobilized PVA hydrogel-hydroxyapatite composites prepared by kneading methods as a material for peripheral cuff of artificial cornea

Hisatoshi Kobayashi, Masabumi Kato, Tetsushi Taguchi, Toshiyuki Ikoma, Hideyuki Miyashita, Shigeto Shimmura, Kazuo Tsubota, Junzo Tanaka

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

In order to achieve the firm fixation of the artificial cornea to host tissues, composites of collagen-immobilized poly(vinyl alcohol) hydrogel with hydroxyapatite were synthesized by a hydroxyapatite particles kneading method. The preparation method, characterization, and the results of corneal cell adhesion and proliferation on the composite material were studied. PVA-COL-HAp composites were successfully synthesized. A micro-porous structure of the PVA-COL-HAp could be introduced by hydrochloric acid treatment and the porosity could be controlled by the pH of the hydrochloric acid solution, the treatment time, and the crystallinity of the HAp particles, Chick embryonic keratocyto-like cells were well attached and proliferated on the PVA-COL-HAp composites. This material showed potential for keratoprosthesis application. Further study such as a long-term animal study is now required.

Original languageEnglish
Pages (from-to)729-735
Number of pages7
JournalMaterials Science and Engineering C
Volume24
Issue number6-8 SPEC. ISS.
DOIs
Publication statusPublished - 2004 Dec 1
Externally publishedYes

Keywords

  • Artificial cornea
  • PVA-collagen-hydroxyapatite composites hydrogel
  • Peripheral cuff

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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