Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation

Gen Sakai; Tomoharu Yajima; Hiromasa Takaishi; Takehiko Mori; Hajime Higuchi; Shoko Nakamura; Shinsuke Funakoshi; Masayuki Adachi; Motoko Izumiya; Hideko Akagi; Yasuo Hamamoto; Takanori Kanai; Makio Mukai; Shinichiro Okamoto; Toshifumi Hibi

Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation

Gen Sakai, Tomoharu Yajima, Hiromasa Takaishi, Takehiko Mori, Hajime Higuchi, Shoko Nakamura, Shinsuke Funakoshi, Masayuki Adachi, Motoko Izumiya, Hideko Akagi, Yasuo Hamamoto, Takanori Kanai, Makio Mukai, Shinichiro Okamoto, Toshifumi Hibi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: Although previous studies indicate that gastrointestinal (GI) cancer may originate from cells recruited from bone marrow (BM) in mice, whether similar phenomena occur in humans is controversial. In the current study, we evaluated two female patients who developed colonic adenocarcinoma more than 10 years after gender-mismatched BM transplantation, and followingly underwent successful endoscopic mucosal resection. Materials and Methods: Fluorescent in situ hybridization (FISH) analysis was used to determine whether the tumours contained donor-derived BM cells. Results: Approximately 1.2% of the tumour cells contained Y-chromosome-positive signals, and a comparable percentage of normal colonic epithelial cells close to the tumour also contained Y-chromosome-positive signals. Conclusion: These results do not support the concept that GI cancer can originate from BM-derived cells.

Original language	English
Pages (from-to)	4097-4103
Number of pages	7
Journal	Anticancer research
Volume	32
Issue number	9
Publication status	Published - 2012 Sept 1

Keywords

Cancer stem cell
Colon cancer
In situ hybridization
Sex-mismatched bone marrow transplantation

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation",

abstract = "Background: Although previous studies indicate that gastrointestinal (GI) cancer may originate from cells recruited from bone marrow (BM) in mice, whether similar phenomena occur in humans is controversial. In the current study, we evaluated two female patients who developed colonic adenocarcinoma more than 10 years after gender-mismatched BM transplantation, and followingly underwent successful endoscopic mucosal resection. Materials and Methods: Fluorescent in situ hybridization (FISH) analysis was used to determine whether the tumours contained donor-derived BM cells. Results: Approximately 1.2% of the tumour cells contained Y-chromosome-positive signals, and a comparable percentage of normal colonic epithelial cells close to the tumour also contained Y-chromosome-positive signals. Conclusion: These results do not support the concept that GI cancer can originate from BM-derived cells.",

keywords = "Cancer stem cell, Colon cancer, In situ hybridization, Sex-mismatched bone marrow transplantation",

author = "Gen Sakai and Tomoharu Yajima and Hiromasa Takaishi and Takehiko Mori and Hajime Higuchi and Shoko Nakamura and Shinsuke Funakoshi and Masayuki Adachi and Motoko Izumiya and Hideko Akagi and Yasuo Hamamoto and Takanori Kanai and Makio Mukai and Shinichiro Okamoto and Toshifumi Hibi",

year = "2012",

month = sep,

day = "1",

language = "English",

volume = "32",

pages = "4097--4103",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "9",

}

TY - JOUR

T1 - Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation

AU - Sakai, Gen

AU - Yajima, Tomoharu

AU - Takaishi, Hiromasa

AU - Mori, Takehiko

AU - Higuchi, Hajime

AU - Nakamura, Shoko

AU - Funakoshi, Shinsuke

AU - Adachi, Masayuki

AU - Izumiya, Motoko

AU - Akagi, Hideko

AU - Hamamoto, Yasuo

AU - Kanai, Takanori

AU - Mukai, Makio

AU - Okamoto, Shinichiro

AU - Hibi, Toshifumi

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background: Although previous studies indicate that gastrointestinal (GI) cancer may originate from cells recruited from bone marrow (BM) in mice, whether similar phenomena occur in humans is controversial. In the current study, we evaluated two female patients who developed colonic adenocarcinoma more than 10 years after gender-mismatched BM transplantation, and followingly underwent successful endoscopic mucosal resection. Materials and Methods: Fluorescent in situ hybridization (FISH) analysis was used to determine whether the tumours contained donor-derived BM cells. Results: Approximately 1.2% of the tumour cells contained Y-chromosome-positive signals, and a comparable percentage of normal colonic epithelial cells close to the tumour also contained Y-chromosome-positive signals. Conclusion: These results do not support the concept that GI cancer can originate from BM-derived cells.

AB - Background: Although previous studies indicate that gastrointestinal (GI) cancer may originate from cells recruited from bone marrow (BM) in mice, whether similar phenomena occur in humans is controversial. In the current study, we evaluated two female patients who developed colonic adenocarcinoma more than 10 years after gender-mismatched BM transplantation, and followingly underwent successful endoscopic mucosal resection. Materials and Methods: Fluorescent in situ hybridization (FISH) analysis was used to determine whether the tumours contained donor-derived BM cells. Results: Approximately 1.2% of the tumour cells contained Y-chromosome-positive signals, and a comparable percentage of normal colonic epithelial cells close to the tumour also contained Y-chromosome-positive signals. Conclusion: These results do not support the concept that GI cancer can originate from BM-derived cells.

KW - Cancer stem cell

KW - Colon cancer

KW - In situ hybridization

KW - Sex-mismatched bone marrow transplantation

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M3 - Article

C2 - 22993367

AN - SCOPUS:84866992450

SN - 0250-7005

VL - 32

SP - 4097

EP - 4103

JO - Anticancer Research

JF - Anticancer Research

IS - 9

ER -

Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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