Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development

Maiko Wakita, Hitomi I. Sano, Yasuhiro Naito, Masaru Tomita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

During rodent ventricular cell development, the sarcoplasmic reticulum (SR) is scarce and poorly organized. A Ca2+ transient in embryonic ventricular cells depends mostly on Ca2+ influx through L-type Ca2+ channels. In rat ventricular cells, transverse tubules (t-tubules) begin to form postnatally. As such, Ca2+-induced Ca2+ release (CICR), in which ryanodine receptor channels on the SR are activated via Ca2+ influx through L-type Ca2+ channels on the t-tubules, is not established in embryonic ventricular cells. Here, we modeled developmental changes in Guinea pig ventricular cells and identified the factors that enhance contraction of the cells with an increase in CICR.

Original languageEnglish
Title of host publicationComputing in Cardiology Conference, CinC 2016
PublisherIEEE Computer Society
Pages1093-1096
Number of pages4
Volume43
ISBN (Electronic)9781509008964
Publication statusPublished - 2017 Mar 1
Event43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
Duration: 2016 Sep 112016 Sep 14

Other

Other43rd Computing in Cardiology Conference, CinC 2016
CountryCanada
CityVancouver
Period16/9/1116/9/14

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ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Wakita, M., Sano, H. I., Naito, Y., & Tomita, M. (2017). Combination of quantitative changes in ionic components to enhance the contractile force during T-tubule development. In Computing in Cardiology Conference, CinC 2016 (Vol. 43, pp. 1093-1096). [7868937] IEEE Computer Society.