Combined effects of radiation and 5-FU derivatives

H. Miyamoto, T. Dokiya, J. Tominaga, E. Kunieda, N. Shigematsu, S. Hashimoto

Research output: Contribution to journalArticle

Abstract

The combined effects of X-ray irradiation and 5-FU derivatives (5-FU, tegafur, HCFU) treatment were investigated in mouse adenocarcinoma-755. Mice were given a single irradiation 5 Gy or 10 Gy of 6-MV X-rays and orally administered 5-FU derivatives at the time of pre- or post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation, in combination with 5-FU, tegafur or HCFU. The antitumor effects and survival time were greater for pre-irradiation treatment than for post-irradiation. Among 5-FU derivatives, the highest combination effect was shown by HCFU, followed by 5-FU and tegafur. The concentration of 5-FU in the tumor was correlated with the antitumor effect of each drug.

Original languageEnglish
Pages (from-to)570-577
Number of pages8
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume13
Issue number3 Pt 1
Publication statusPublished - 1986 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Miyamoto, H., Dokiya, T., Tominaga, J., Kunieda, E., Shigematsu, N., & Hashimoto, S. (1986). Combined effects of radiation and 5-FU derivatives. Gan to kagaku ryoho. Cancer & chemotherapy, 13(3 Pt 1), 570-577.