Combined effects of radiation and 5-FU derivatives

H. Miyamoto; T. Dokiya; J. Tominaga; E. Kunieda; N. Shigematsu; S. Hashimoto

Combined effects of radiation and 5-FU derivatives

H. Miyamoto, T. Dokiya, J. Tominaga, E. Kunieda, N. Shigematsu, S. Hashimoto

Research output: Contribution to journal › Article › peer-review

Abstract

The combined effects of X-ray irradiation and 5-FU derivatives (5-FU, tegafur, HCFU) treatment were investigated in mouse adenocarcinoma-755. Mice were given a single irradiation 5 Gy or 10 Gy of 6-MV X-rays and orally administered 5-FU derivatives at the time of pre- or post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation, in combination with 5-FU, tegafur or HCFU. The antitumor effects and survival time were greater for pre-irradiation treatment than for post-irradiation. Among 5-FU derivatives, the highest combination effect was shown by HCFU, followed by 5-FU and tegafur. The concentration of 5-FU in the tumor was correlated with the antitumor effect of each drug.

Original language	English
Pages (from-to)	570-577
Number of pages	8
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
Volume	13
Issue number	3 Pt 1
Publication status	Published - 1986 Mar
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Combined effects of radiation and 5-FU derivatives",

abstract = "The combined effects of X-ray irradiation and 5-FU derivatives (5-FU, tegafur, HCFU) treatment were investigated in mouse adenocarcinoma-755. Mice were given a single irradiation 5 Gy or 10 Gy of 6-MV X-rays and orally administered 5-FU derivatives at the time of pre- or post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation, in combination with 5-FU, tegafur or HCFU. The antitumor effects and survival time were greater for pre-irradiation treatment than for post-irradiation. Among 5-FU derivatives, the highest combination effect was shown by HCFU, followed by 5-FU and tegafur. The concentration of 5-FU in the tumor was correlated with the antitumor effect of each drug.",

author = "H. Miyamoto and T. Dokiya and J. Tominaga and E. Kunieda and N. Shigematsu and S. Hashimoto",

year = "1986",

month = mar,

language = "English",

volume = "13",

pages = "570--577",

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TY - JOUR

T1 - Combined effects of radiation and 5-FU derivatives

AU - Miyamoto, H.

AU - Dokiya, T.

AU - Tominaga, J.

AU - Kunieda, E.

AU - Shigematsu, N.

AU - Hashimoto, S.

PY - 1986/3

Y1 - 1986/3

N2 - The combined effects of X-ray irradiation and 5-FU derivatives (5-FU, tegafur, HCFU) treatment were investigated in mouse adenocarcinoma-755. Mice were given a single irradiation 5 Gy or 10 Gy of 6-MV X-rays and orally administered 5-FU derivatives at the time of pre- or post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation, in combination with 5-FU, tegafur or HCFU. The antitumor effects and survival time were greater for pre-irradiation treatment than for post-irradiation. Among 5-FU derivatives, the highest combination effect was shown by HCFU, followed by 5-FU and tegafur. The concentration of 5-FU in the tumor was correlated with the antitumor effect of each drug.

AB - The combined effects of X-ray irradiation and 5-FU derivatives (5-FU, tegafur, HCFU) treatment were investigated in mouse adenocarcinoma-755. Mice were given a single irradiation 5 Gy or 10 Gy of 6-MV X-rays and orally administered 5-FU derivatives at the time of pre- or post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation. Under these conditions, antitumor activity and survival time were compared between pre- and post-irradiation, in combination with 5-FU, tegafur or HCFU. The antitumor effects and survival time were greater for pre-irradiation treatment than for post-irradiation. Among 5-FU derivatives, the highest combination effect was shown by HCFU, followed by 5-FU and tegafur. The concentration of 5-FU in the tumor was correlated with the antitumor effect of each drug.

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M3 - Article

C2 - 3082291

AN - SCOPUS:0022685238

SN - 0385-0684

VL - 13

SP - 570

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JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 3 Pt 1

ER -

Combined effects of radiation and 5-FU derivatives

Abstract

ASJC Scopus subject areas

UN SDGs

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