Combined gangliocytoma and prolactinoma of the pituitary gland

Shuji Mikami, Kaori Kameyama, Satoshi Takahashi, Kazunari Yoshida, Takeshi Kawase, Toshiaki Sano, Makio Mukai

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Gangliocytomas of the pituitary gland are rare lesions that often occur in combination with pituitary adenomas, which are frequently associated with the hypersecretion of pituitary hormones, particularly growth hormones. We report a case of combined gangliocytoma and prolactinoma of the pituitary gland. A 49-year-old male presented with vertigo. Radiological examination revealed an intrasellar tumor with a suprasellar extension, which was removed via the trans-sphenoidal approach. Histologically, the tumor was composed of adenoma cells, mature ganglion cells and cells with features intermediate between those of adenoma cells and ganglion cells (intermediate cells). Immunohistochemical analysis revealed the ganglion cells and intermediate cells as well as adenoma cells to be positive for prolactin. No growth hormone-positive tumor cells were observed. The ganglion cells were positive for synaptophysin and neurofilament. The findings in this case are discussed in relation to hypotheses proposed for histogenesis, and the presence of intermediate cells supports three hypotheses. The first is that adenoma cells transform into ganglion cells, and the second is that both components originate from the embryonal pituitary cell rests, showing intermediate features between ganglion cells and adenoma cells. The last is that their common origin may be the same stem/progenitor cells in normal adult pituitaries.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalEndocrine Pathology
Volume19
Issue number2
DOIs
Publication statusPublished - 2008 Jun

Fingerprint

Ganglioneuroma
Prolactinoma
Pituitary Gland
Ganglia
Adenoma
Growth Hormone
Stem Cells
Neoplasms
Synaptophysin

Keywords

  • Gangliocytoma
  • Pituitary gland
  • Prolactinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Combined gangliocytoma and prolactinoma of the pituitary gland. / Mikami, Shuji; Kameyama, Kaori; Takahashi, Satoshi; Yoshida, Kazunari; Kawase, Takeshi; Sano, Toshiaki; Mukai, Makio.

In: Endocrine Pathology, Vol. 19, No. 2, 06.2008, p. 117-121.

Research output: Contribution to journalArticle

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