Combined primary aldosteronism and Cushing's syndrome due to a single adrenocortical adenoma complicated by Hashimoto's thyroiditis

Masami Tanaka, Masakazu Izeki, Yasushi Miyazaki, Masayuki Horigome, Takashi Yoneda, Shizuo Tsuyuki, Shigeto Takami, Motohiko Aiba

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A 43-year-old Japanese woman presented hypertension, hypokalemia and typical Cushingoid signs. Autonomous secretion of both aldosterone and cortisol was shown. Abdominal computed tomography demonstrated a single tumor in the right adrenal gland, which established the diagnosis of combined primary aldosteronism and Cushing's syndrome. The resected tumor was a golden yellow-colored adenoma (diameter 4.3 cm) which expressed P450aldo and P45011β, causing oversecretion of both hormones from this adenoma. After tumor resection, overproduction of both hormones disappeared and she developed adrenal insufficiency, suggesting the strong suppression of normal adrenal function. This case was complicated by Hashimoto's thyroiditis.

Original languageEnglish
Pages (from-to)967-971
Number of pages5
JournalInternal Medicine
Volume41
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1
Externally publishedYes

Keywords

  • Adrenal insufficiency
  • Aldosterone
  • Cortisol

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Combined primary aldosteronism and Cushing's syndrome due to a single adrenocortical adenoma complicated by Hashimoto's thyroiditis'. Together they form a unique fingerprint.

  • Cite this