Combined primary aldosteronism and Cushing's syndrome due to a single adrenocortical adenoma complicated by Hashimoto's thyroiditis

Masami Tanaka, Masakazu Izeki, Yasushi Miyazaki, Masayuki Horigome, Takashi Yoneda, Shizuo Tsuyuki, Shigeto Takami, Motohiko Aiba

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A 43-year-old Japanese woman presented hypertension, hypokalemia and typical Cushingoid signs. Autonomous secretion of both aldosterone and cortisol was shown. Abdominal computed tomography demonstrated a single tumor in the right adrenal gland, which established the diagnosis of combined primary aldosteronism and Cushing's syndrome. The resected tumor was a golden yellow-colored adenoma (diameter 4.3 cm) which expressed P450aldo and P45011β, causing oversecretion of both hormones from this adenoma. After tumor resection, overproduction of both hormones disappeared and she developed adrenal insufficiency, suggesting the strong suppression of normal adrenal function. This case was complicated by Hashimoto's thyroiditis.

Original languageEnglish
Pages (from-to)967-971
Number of pages5
JournalInternal Medicine
Volume41
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1
Externally publishedYes

Fingerprint

Adrenocortical Adenoma
Hashimoto Disease
Hyperaldosteronism
Cushing Syndrome
Adenoma
Hormones
Neoplasms
Adrenal Insufficiency
Hypokalemia
Adrenal Glands
Aldosterone
Hydrocortisone
Tomography
Hypertension

Keywords

  • Adrenal insufficiency
  • Aldosterone
  • Cortisol

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Combined primary aldosteronism and Cushing's syndrome due to a single adrenocortical adenoma complicated by Hashimoto's thyroiditis. / Tanaka, Masami; Izeki, Masakazu; Miyazaki, Yasushi; Horigome, Masayuki; Yoneda, Takashi; Tsuyuki, Shizuo; Takami, Shigeto; Aiba, Motohiko.

In: Internal Medicine, Vol. 41, No. 11, 01.11.2002, p. 967-971.

Research output: Contribution to journalArticle

Tanaka, Masami ; Izeki, Masakazu ; Miyazaki, Yasushi ; Horigome, Masayuki ; Yoneda, Takashi ; Tsuyuki, Shizuo ; Takami, Shigeto ; Aiba, Motohiko. / Combined primary aldosteronism and Cushing's syndrome due to a single adrenocortical adenoma complicated by Hashimoto's thyroiditis. In: Internal Medicine. 2002 ; Vol. 41, No. 11. pp. 967-971.
@article{c91daaa541ea43c5bbcf70def0d6ea0e,
title = "Combined primary aldosteronism and Cushing's syndrome due to a single adrenocortical adenoma complicated by Hashimoto's thyroiditis",
abstract = "A 43-year-old Japanese woman presented hypertension, hypokalemia and typical Cushingoid signs. Autonomous secretion of both aldosterone and cortisol was shown. Abdominal computed tomography demonstrated a single tumor in the right adrenal gland, which established the diagnosis of combined primary aldosteronism and Cushing's syndrome. The resected tumor was a golden yellow-colored adenoma (diameter 4.3 cm) which expressed P450aldo and P45011β, causing oversecretion of both hormones from this adenoma. After tumor resection, overproduction of both hormones disappeared and she developed adrenal insufficiency, suggesting the strong suppression of normal adrenal function. This case was complicated by Hashimoto's thyroiditis.",
keywords = "Adrenal insufficiency, Aldosterone, Cortisol",
author = "Masami Tanaka and Masakazu Izeki and Yasushi Miyazaki and Masayuki Horigome and Takashi Yoneda and Shizuo Tsuyuki and Shigeto Takami and Motohiko Aiba",
year = "2002",
month = "11",
day = "1",
doi = "10.2169/internalmedicine.41.967",
language = "English",
volume = "41",
pages = "967--971",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "11",

}

TY - JOUR

T1 - Combined primary aldosteronism and Cushing's syndrome due to a single adrenocortical adenoma complicated by Hashimoto's thyroiditis

AU - Tanaka, Masami

AU - Izeki, Masakazu

AU - Miyazaki, Yasushi

AU - Horigome, Masayuki

AU - Yoneda, Takashi

AU - Tsuyuki, Shizuo

AU - Takami, Shigeto

AU - Aiba, Motohiko

PY - 2002/11/1

Y1 - 2002/11/1

N2 - A 43-year-old Japanese woman presented hypertension, hypokalemia and typical Cushingoid signs. Autonomous secretion of both aldosterone and cortisol was shown. Abdominal computed tomography demonstrated a single tumor in the right adrenal gland, which established the diagnosis of combined primary aldosteronism and Cushing's syndrome. The resected tumor was a golden yellow-colored adenoma (diameter 4.3 cm) which expressed P450aldo and P45011β, causing oversecretion of both hormones from this adenoma. After tumor resection, overproduction of both hormones disappeared and she developed adrenal insufficiency, suggesting the strong suppression of normal adrenal function. This case was complicated by Hashimoto's thyroiditis.

AB - A 43-year-old Japanese woman presented hypertension, hypokalemia and typical Cushingoid signs. Autonomous secretion of both aldosterone and cortisol was shown. Abdominal computed tomography demonstrated a single tumor in the right adrenal gland, which established the diagnosis of combined primary aldosteronism and Cushing's syndrome. The resected tumor was a golden yellow-colored adenoma (diameter 4.3 cm) which expressed P450aldo and P45011β, causing oversecretion of both hormones from this adenoma. After tumor resection, overproduction of both hormones disappeared and she developed adrenal insufficiency, suggesting the strong suppression of normal adrenal function. This case was complicated by Hashimoto's thyroiditis.

KW - Adrenal insufficiency

KW - Aldosterone

KW - Cortisol

UR - http://www.scopus.com/inward/record.url?scp=0036858964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036858964&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.41.967

DO - 10.2169/internalmedicine.41.967

M3 - Article

C2 - 12487169

AN - SCOPUS:0036858964

VL - 41

SP - 967

EP - 971

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 11

ER -