Comparative effect of 6% hydroxyethyl starch (containing 1% dextrose) and lactated Ringer's solution for cesarean section under spinal anesthesia

Tomoko Yorozu, Hiroshi Morisaki, Masahiro Kondoh, Misako Zenfuku, Toshiyuki Shigematsu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose. This study aimed to compare low-molecular weight hydroxyethyl starch containing 1% dextrose (HES) infusion and lactated Ringer's solution (LR) in the prevention of hypotension associated with spinal anesthesia for cesarean section. Methods. Sixty-seven patients scheduled for cesarean section under spinal anesthesia were randomly allocated to receive either LR (n = 35) or HES (n = 32) infusion before cesarean delivery. Infusion of the fluid was started immediately after arrival at the operating room, through two fully open i.v. routes of 18 or 16 gauge. The two groups were compared in terms of the incidence of hypotension; ephedrine dose; cord and maternal blood gas, hemoglobin, and glucose; and Apgar scores. Results. Intravenous fluid volume until delivery in the LR group was significantly greater than that in the HES group (1298 ± 503 and 973 ± 339 ml, respectively) in spite of the similar periods of intravenous infusion (18.1 ± 3.9 and 18.2 ± 4.1 min). The incidence of hypotension, and the ephedrine dose, blood gas analyses, and Apgar scores were not significantly different between the groups. The ephedrine dose correlated with the anesthesia level by spinal anesthesia (P < 0.05). Conclusion. This study did not show an advantage of HES compared with LR in the prevention of hypotension or in the reduction of ephedrine dose during cesarean section under spinal anesthesia. The anesthesia level, rather than the choice of intravenous fluid solution, might be related to the ephedrine dose.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalJournal of Anesthesia
Volume16
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Ephedrine
Spinal Anesthesia
Cesarean Section
Starch
Hypotension
Glucose
Apgar Score
Anesthesia
Blood Gas Analysis
Incidence
Operating Rooms
Fetal Blood
Intravenous Infusions
Hemoglobins
Molecular Weight
Gases
Mothers
Ringer's lactate
Ringer's solution

Keywords

  • Cesarean section
  • Hydroxyethyl starch
  • Spinal anesthesia
  • Spinal hypotension

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Comparative effect of 6% hydroxyethyl starch (containing 1% dextrose) and lactated Ringer's solution for cesarean section under spinal anesthesia. / Yorozu, Tomoko; Morisaki, Hiroshi; Kondoh, Masahiro; Zenfuku, Misako; Shigematsu, Toshiyuki.

In: Journal of Anesthesia, Vol. 16, No. 3, 2002, p. 203-206.

Research output: Contribution to journalArticle

@article{6bc8287fcd744e728e6e447d24c49b54,
title = "Comparative effect of 6{\%} hydroxyethyl starch (containing 1{\%} dextrose) and lactated Ringer's solution for cesarean section under spinal anesthesia",
abstract = "Purpose. This study aimed to compare low-molecular weight hydroxyethyl starch containing 1{\%} dextrose (HES) infusion and lactated Ringer's solution (LR) in the prevention of hypotension associated with spinal anesthesia for cesarean section. Methods. Sixty-seven patients scheduled for cesarean section under spinal anesthesia were randomly allocated to receive either LR (n = 35) or HES (n = 32) infusion before cesarean delivery. Infusion of the fluid was started immediately after arrival at the operating room, through two fully open i.v. routes of 18 or 16 gauge. The two groups were compared in terms of the incidence of hypotension; ephedrine dose; cord and maternal blood gas, hemoglobin, and glucose; and Apgar scores. Results. Intravenous fluid volume until delivery in the LR group was significantly greater than that in the HES group (1298 ± 503 and 973 ± 339 ml, respectively) in spite of the similar periods of intravenous infusion (18.1 ± 3.9 and 18.2 ± 4.1 min). The incidence of hypotension, and the ephedrine dose, blood gas analyses, and Apgar scores were not significantly different between the groups. The ephedrine dose correlated with the anesthesia level by spinal anesthesia (P < 0.05). Conclusion. This study did not show an advantage of HES compared with LR in the prevention of hypotension or in the reduction of ephedrine dose during cesarean section under spinal anesthesia. The anesthesia level, rather than the choice of intravenous fluid solution, might be related to the ephedrine dose.",
keywords = "Cesarean section, Hydroxyethyl starch, Spinal anesthesia, Spinal hypotension",
author = "Tomoko Yorozu and Hiroshi Morisaki and Masahiro Kondoh and Misako Zenfuku and Toshiyuki Shigematsu",
year = "2002",
doi = "10.1007/s005400200025",
language = "English",
volume = "16",
pages = "203--206",
journal = "Journal of Anesthesia",
issn = "0913-8668",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Comparative effect of 6% hydroxyethyl starch (containing 1% dextrose) and lactated Ringer's solution for cesarean section under spinal anesthesia

AU - Yorozu, Tomoko

AU - Morisaki, Hiroshi

AU - Kondoh, Masahiro

AU - Zenfuku, Misako

AU - Shigematsu, Toshiyuki

PY - 2002

Y1 - 2002

N2 - Purpose. This study aimed to compare low-molecular weight hydroxyethyl starch containing 1% dextrose (HES) infusion and lactated Ringer's solution (LR) in the prevention of hypotension associated with spinal anesthesia for cesarean section. Methods. Sixty-seven patients scheduled for cesarean section under spinal anesthesia were randomly allocated to receive either LR (n = 35) or HES (n = 32) infusion before cesarean delivery. Infusion of the fluid was started immediately after arrival at the operating room, through two fully open i.v. routes of 18 or 16 gauge. The two groups were compared in terms of the incidence of hypotension; ephedrine dose; cord and maternal blood gas, hemoglobin, and glucose; and Apgar scores. Results. Intravenous fluid volume until delivery in the LR group was significantly greater than that in the HES group (1298 ± 503 and 973 ± 339 ml, respectively) in spite of the similar periods of intravenous infusion (18.1 ± 3.9 and 18.2 ± 4.1 min). The incidence of hypotension, and the ephedrine dose, blood gas analyses, and Apgar scores were not significantly different between the groups. The ephedrine dose correlated with the anesthesia level by spinal anesthesia (P < 0.05). Conclusion. This study did not show an advantage of HES compared with LR in the prevention of hypotension or in the reduction of ephedrine dose during cesarean section under spinal anesthesia. The anesthesia level, rather than the choice of intravenous fluid solution, might be related to the ephedrine dose.

AB - Purpose. This study aimed to compare low-molecular weight hydroxyethyl starch containing 1% dextrose (HES) infusion and lactated Ringer's solution (LR) in the prevention of hypotension associated with spinal anesthesia for cesarean section. Methods. Sixty-seven patients scheduled for cesarean section under spinal anesthesia were randomly allocated to receive either LR (n = 35) or HES (n = 32) infusion before cesarean delivery. Infusion of the fluid was started immediately after arrival at the operating room, through two fully open i.v. routes of 18 or 16 gauge. The two groups were compared in terms of the incidence of hypotension; ephedrine dose; cord and maternal blood gas, hemoglobin, and glucose; and Apgar scores. Results. Intravenous fluid volume until delivery in the LR group was significantly greater than that in the HES group (1298 ± 503 and 973 ± 339 ml, respectively) in spite of the similar periods of intravenous infusion (18.1 ± 3.9 and 18.2 ± 4.1 min). The incidence of hypotension, and the ephedrine dose, blood gas analyses, and Apgar scores were not significantly different between the groups. The ephedrine dose correlated with the anesthesia level by spinal anesthesia (P < 0.05). Conclusion. This study did not show an advantage of HES compared with LR in the prevention of hypotension or in the reduction of ephedrine dose during cesarean section under spinal anesthesia. The anesthesia level, rather than the choice of intravenous fluid solution, might be related to the ephedrine dose.

KW - Cesarean section

KW - Hydroxyethyl starch

KW - Spinal anesthesia

KW - Spinal hypotension

UR - http://www.scopus.com/inward/record.url?scp=0036388145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036388145&partnerID=8YFLogxK

U2 - 10.1007/s005400200025

DO - 10.1007/s005400200025

M3 - Article

VL - 16

SP - 203

EP - 206

JO - Journal of Anesthesia

JF - Journal of Anesthesia

SN - 0913-8668

IS - 3

ER -