Comparative pharmacokinetics of cefazolin in awake and urethane-anesthetized rats

T. Terasaki, A. Tsuji, E. Nakashima, K. Nishide, C. H. Nightingale, T. Yamana

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The influence of urethane and pentobarbital anesthesia on the pharmacokinetics of cefazolin has been investigated in rats. No significant difference of total body clearance or distribution volume was observed between urethane-anesthetized and non-anesthetized rats. There was also no significant difference in plasma concentration of cefazolin at the terminal phase between urethane-anesthetized, pentobarbital-anesthetized and non-anesthetized rats. Good coincidence was demonstrated between the observed tissue-to-plasma partition coefficient, K(p), of non-anesthetized rats and the predicted K(p) value based on the previously proposed model. Hence, it is considered that there is no significant influence of urethane or pentobarbital anesthesia on the distribution and elimination of cefazolin. The proposed physiological model could be useful to predict the distribution of cefazolin in non-anesthetized rats.

Original languageEnglish
Pages (from-to)2153-2157
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume33
Issue number5
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Cefazolin
Pharmacokinetics
Urethane
Rats
Pentobarbital
Anesthesia
Physiological models
Plasmas
Tissue

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Terasaki, T., Tsuji, A., Nakashima, E., Nishide, K., Nightingale, C. H., & Yamana, T. (1985). Comparative pharmacokinetics of cefazolin in awake and urethane-anesthetized rats. Chemical and Pharmaceutical Bulletin, 33(5), 2153-2157.

Comparative pharmacokinetics of cefazolin in awake and urethane-anesthetized rats. / Terasaki, T.; Tsuji, A.; Nakashima, E.; Nishide, K.; Nightingale, C. H.; Yamana, T.

In: Chemical and Pharmaceutical Bulletin, Vol. 33, No. 5, 1985, p. 2153-2157.

Research output: Contribution to journalArticle

Terasaki, T, Tsuji, A, Nakashima, E, Nishide, K, Nightingale, CH & Yamana, T 1985, 'Comparative pharmacokinetics of cefazolin in awake and urethane-anesthetized rats', Chemical and Pharmaceutical Bulletin, vol. 33, no. 5, pp. 2153-2157.
Terasaki T, Tsuji A, Nakashima E, Nishide K, Nightingale CH, Yamana T. Comparative pharmacokinetics of cefazolin in awake and urethane-anesthetized rats. Chemical and Pharmaceutical Bulletin. 1985;33(5):2153-2157.
Terasaki, T. ; Tsuji, A. ; Nakashima, E. ; Nishide, K. ; Nightingale, C. H. ; Yamana, T. / Comparative pharmacokinetics of cefazolin in awake and urethane-anesthetized rats. In: Chemical and Pharmaceutical Bulletin. 1985 ; Vol. 33, No. 5. pp. 2153-2157.
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