Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma

Ukihide Tateishi; Ako Hosono; Atsushi Makimoto; Yuki Nakamoto; Tomohiro Kaneta; Hiroshi Fukuda; Koji Murakami; Takashi Terauchi; Tsuyoshi Suga; Tomio Inoue; Edmund E. Kim

doi:10.1007/s12149-008-0219-z

Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma

Ukihide Tateishi, Ako Hosono, Atsushi Makimoto, Yuki Nakamoto, Tomohiro Kaneta, Hiroshi Fukuda, Koji Murakami, Takashi Terauchi, Tsuyoshi Suga, Tomio Inoue, Edmund E. Kim

Department of Radiology

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

Objective: The current study was conducted to compare the diagnostic accuracy between ¹⁸F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT), and conventional imaging (CI) for the staging and re-staging of patients with rhabdomyosarcomas. Methods: Thirty-five patients who underwent FDG PET/CT prior to treatment were evaluated retrospectively. CI methods consisted of ^99mTc-hydroxymethylene diphosphonate bone scintigraphy, chest radiograph, whole body CT, and magnetic resonance imaging of the primary site. The images were reviewed and two boardcertified radiologists reached a diagnostic consensus. Tumor stage was confirmed by histological examination and/or follow-up examinations. Results: Interpretation on the basis of FDG PET/CT, and CI, diagnostic accuracies of the T and N stages were similar. Using FDG PET/CT, the M stage was correctly assigned in 31 patients (89%), whereas the accuracy of CI in M stage was 63%. TNM stage was correctly assessed with FDG PET/CT in 30 of 35 patients (86%) and with CI in 19 of 35 patients (54%). The overall TNM staging and M staging accuracies of FDG PET/CT were significantly higher than that of CI (P < 0.01). Conclusions: FDG PET/CT is more accurate than CI regarding clinical staging and re-staging of patients with rhabdomyosarcomas.

Original language	English
Pages (from-to)	155-161
Number of pages	7
Journal	Annals of Nuclear Medicine
Volume	23
Issue number	2
DOIs	https://doi.org/10.1007/s12149-008-0219-z
Publication status	Published - 2009 Feb

Keywords

FDG PET/CT
Rhabdomyosarcoma
Stage

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s12149-008-0219-z

Cite this

@article{0b265acd2da741c485600fc93ab8fd75,

title = "Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma",

abstract = "Objective: The current study was conducted to compare the diagnostic accuracy between 18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT), and conventional imaging (CI) for the staging and re-staging of patients with rhabdomyosarcomas. Methods: Thirty-five patients who underwent FDG PET/CT prior to treatment were evaluated retrospectively. CI methods consisted of 99mTc-hydroxymethylene diphosphonate bone scintigraphy, chest radiograph, whole body CT, and magnetic resonance imaging of the primary site. The images were reviewed and two boardcertified radiologists reached a diagnostic consensus. Tumor stage was confirmed by histological examination and/or follow-up examinations. Results: Interpretation on the basis of FDG PET/CT, and CI, diagnostic accuracies of the T and N stages were similar. Using FDG PET/CT, the M stage was correctly assigned in 31 patients (89%), whereas the accuracy of CI in M stage was 63%. TNM stage was correctly assessed with FDG PET/CT in 30 of 35 patients (86%) and with CI in 19 of 35 patients (54%). The overall TNM staging and M staging accuracies of FDG PET/CT were significantly higher than that of CI (P < 0.01). Conclusions: FDG PET/CT is more accurate than CI regarding clinical staging and re-staging of patients with rhabdomyosarcomas.",

keywords = "FDG PET/CT, Rhabdomyosarcoma, Stage",

author = "Ukihide Tateishi and Ako Hosono and Atsushi Makimoto and Yuki Nakamoto and Tomohiro Kaneta and Hiroshi Fukuda and Koji Murakami and Takashi Terauchi and Tsuyoshi Suga and Tomio Inoue and Kim, {Edmund E.}",

note = "Funding Information: Acknowledgments The authors greatly thank for their assistance; Nagara Tamaki, MD, Noboru Oriuchi, MD, Keigo Endo, MD, Hiroshi Fujii, MD, Michio Senda, MD, Takashi Terauchi, MD, in the Scientific Research Expenses for Health and Welfare Programs, No. 17–12, the promotion and standardization of diagnostic accuracy in PET/CT imaging. This work was supported in part by grants from Scientific Research Expenses for Health and Welfare Programs, No. 17–12, the promotion and standardization of diagnostic accuracy in PET/CT imaging.",

year = "2009",

month = feb,

doi = "10.1007/s12149-008-0219-z",

language = "English",

volume = "23",

pages = "155--161",

journal = "Annals of Nuclear Medicine",

issn = "0914-7187",

publisher = "Springer Japan",

number = "2",

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T1 - Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma

AU - Tateishi, Ukihide

AU - Hosono, Ako

AU - Makimoto, Atsushi

AU - Nakamoto, Yuki

AU - Kaneta, Tomohiro

AU - Fukuda, Hiroshi

AU - Murakami, Koji

AU - Terauchi, Takashi

AU - Suga, Tsuyoshi

AU - Inoue, Tomio

AU - Kim, Edmund E.

N1 - Funding Information: Acknowledgments The authors greatly thank for their assistance; Nagara Tamaki, MD, Noboru Oriuchi, MD, Keigo Endo, MD, Hiroshi Fujii, MD, Michio Senda, MD, Takashi Terauchi, MD, in the Scientific Research Expenses for Health and Welfare Programs, No. 17–12, the promotion and standardization of diagnostic accuracy in PET/CT imaging. This work was supported in part by grants from Scientific Research Expenses for Health and Welfare Programs, No. 17–12, the promotion and standardization of diagnostic accuracy in PET/CT imaging.

PY - 2009/2

Y1 - 2009/2

N2 - Objective: The current study was conducted to compare the diagnostic accuracy between 18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT), and conventional imaging (CI) for the staging and re-staging of patients with rhabdomyosarcomas. Methods: Thirty-five patients who underwent FDG PET/CT prior to treatment were evaluated retrospectively. CI methods consisted of 99mTc-hydroxymethylene diphosphonate bone scintigraphy, chest radiograph, whole body CT, and magnetic resonance imaging of the primary site. The images were reviewed and two boardcertified radiologists reached a diagnostic consensus. Tumor stage was confirmed by histological examination and/or follow-up examinations. Results: Interpretation on the basis of FDG PET/CT, and CI, diagnostic accuracies of the T and N stages were similar. Using FDG PET/CT, the M stage was correctly assigned in 31 patients (89%), whereas the accuracy of CI in M stage was 63%. TNM stage was correctly assessed with FDG PET/CT in 30 of 35 patients (86%) and with CI in 19 of 35 patients (54%). The overall TNM staging and M staging accuracies of FDG PET/CT were significantly higher than that of CI (P < 0.01). Conclusions: FDG PET/CT is more accurate than CI regarding clinical staging and re-staging of patients with rhabdomyosarcomas.

AB - Objective: The current study was conducted to compare the diagnostic accuracy between 18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT), and conventional imaging (CI) for the staging and re-staging of patients with rhabdomyosarcomas. Methods: Thirty-five patients who underwent FDG PET/CT prior to treatment were evaluated retrospectively. CI methods consisted of 99mTc-hydroxymethylene diphosphonate bone scintigraphy, chest radiograph, whole body CT, and magnetic resonance imaging of the primary site. The images were reviewed and two boardcertified radiologists reached a diagnostic consensus. Tumor stage was confirmed by histological examination and/or follow-up examinations. Results: Interpretation on the basis of FDG PET/CT, and CI, diagnostic accuracies of the T and N stages were similar. Using FDG PET/CT, the M stage was correctly assigned in 31 patients (89%), whereas the accuracy of CI in M stage was 63%. TNM stage was correctly assessed with FDG PET/CT in 30 of 35 patients (86%) and with CI in 19 of 35 patients (54%). The overall TNM staging and M staging accuracies of FDG PET/CT were significantly higher than that of CI (P < 0.01). Conclusions: FDG PET/CT is more accurate than CI regarding clinical staging and re-staging of patients with rhabdomyosarcomas.

KW - FDG PET/CT

KW - Rhabdomyosarcoma

KW - Stage

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Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma

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Keywords

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