Comparative study on baseline clinical characteristics of Asian versus non-Asian patients with paroxysmal nocturnal hemoglobinuria

Masatoshi Sakurai, Jun Ho Jang, Wen Chien Chou, Jin Seok Kim, Amanda Wilson, Jun ichi Nishimura, Tzeon Jye Chiou, Yuzuru Kanakura, Jong Wook Lee, Shinichiro Okamoto

Research output: Contribution to journalArticle

Abstract

A difference in clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH) among different races has been suggested. The aim of this study was to clarify whether the clinical characteristics of patients with PNH in the International PNH Registry differ by ethnic background. Patients, who were eculizumab naïve at baseline and had ≥ 1% PNH clone size, were eligible for this analysis. Totally, 1793 patients were enrolled and divided into two cohorts, Asian (N = 246) and non-Asian (N = 1547). The Asian cohort was further divided into Asians in Asia cohort (N = 202) and Asians in non-Asia cohort (N = 44), based on geographical region. The Asian cohort had significantly higher PNH clone size in granulocytes, higher lactate dehydrogenase levels, and lower hemoglobin levels. However, the frequencies of symptoms including abdominal pain, backache, easy bleeding, fatigue and headache at baseline were significantly lower in the Asian cohort. The proportion of patients with a history of thromboembolism (TE) was significantly lower in the Asian than in the non-Asian cohort (3.6% vs. 8.9%, P < 0.01); however, there was no difference between Asians in Asia and Asians in non-Asia (3.3% vs. 4.9%, P = 0.61). These findings suggested that genetic factors may play a stronger role in developing TE than lifestyle factors in PNH patients.

Original languageEnglish
JournalInternational journal of hematology
DOIs
Publication statusPublished - 2019 Jan 1

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Paroxysmal Hemoglobinuria
Thromboembolism
Clone Cells
Back Pain
L-Lactate Dehydrogenase
Granulocytes
Abdominal Pain
Fatigue
Headache
Registries
Life Style
Hemoglobins
Hemorrhage

Keywords

  • Asian
  • International PNH Registry
  • Paroxysmal nocturnal hemoglobinuria
  • Thromboembolism

ASJC Scopus subject areas

  • Hematology

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Comparative study on baseline clinical characteristics of Asian versus non-Asian patients with paroxysmal nocturnal hemoglobinuria. / Sakurai, Masatoshi; Jang, Jun Ho; Chou, Wen Chien; Kim, Jin Seok; Wilson, Amanda; Nishimura, Jun ichi; Chiou, Tzeon Jye; Kanakura, Yuzuru; Lee, Jong Wook; Okamoto, Shinichiro.

In: International journal of hematology, 01.01.2019.

Research output: Contribution to journalArticle

Sakurai, Masatoshi ; Jang, Jun Ho ; Chou, Wen Chien ; Kim, Jin Seok ; Wilson, Amanda ; Nishimura, Jun ichi ; Chiou, Tzeon Jye ; Kanakura, Yuzuru ; Lee, Jong Wook ; Okamoto, Shinichiro. / Comparative study on baseline clinical characteristics of Asian versus non-Asian patients with paroxysmal nocturnal hemoglobinuria. In: International journal of hematology. 2019.
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