Comparative study on bioresorbability of chelate-setting cements with various calcium-phosphate phase using rabbit model

Toshiisa Konishi, Shuhei Takahashi, Minori Mizumoto, Michiyo Honda, Koki Kida, Yukiko Horiguchi, Kazuya Oribe, Ken Ishii, Hikaru Morisue, Yoshiaki Toyama, Morio Matsumoto, Mamoru Aizawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We have developed novel calcium-phosphate cements (CPCs) based on the chelate-setting mechanism of inositol phosphate (IP6) using hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP) and α-TCP as starting materials. These cements (IP6-HAp, IP6-β-TCP and IP6-α-TCP cements) have different bioresorbability due to the chemical composition of starting materials. In the present study, biocompatibility and bioresorbability of the above three cements and commercially available cement (BiopexR-R) was histologically evaluated in vivo using rabbit model for 4, 8, and 24 weeks, in addition to their dissolution in vitro. The dissolution of these cements increased in the order of IP6-HAp, IP6-β-TCP and IP6-α-TCP cements. The newly-formed bones were directly in contact with both the IP6-HAp and BiopexR-R cement specimens. As for the IP6-β-TCP and IP6-α-TCP cements, newly-formed bones were formed time-dependently slightly apart from the cement specimens. Resorption rate for BiopexR-R, IP6-HAp, IP6-β-TCP, and IP6-α-TCP cements after 24 weeks implantation were of 7.2, 5.0, 13.7, and 16.2%, respectively, compared to original cements. The present chelate-setting cements with different bioresorbability are promising candidates for application as the novel CPCs.

Original languageEnglish
Title of host publicationBioceramics 24
PublisherTrans Tech Publications Ltd
Pages167-172
Number of pages6
Edition1
ISBN (Print)9783037855171
DOIs
Publication statusPublished - 2013 Jan 1
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: 2012 Oct 212012 Oct 24

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period12/10/2112/10/24

Keywords

  • Biocompatibility
  • Bioresorbability
  • Bone graft
  • Calcium-phosphate cement
  • Inositol hexaphosphate
  • Surface modification

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Konishi, T., Takahashi, S., Mizumoto, M., Honda, M., Kida, K., Horiguchi, Y., Oribe, K., Ishii, K., Morisue, H., Toyama, Y., Matsumoto, M., & Aizawa, M. (2013). Comparative study on bioresorbability of chelate-setting cements with various calcium-phosphate phase using rabbit model. In Bioceramics 24 (1 ed., pp. 167-172). (Key Engineering Materials; Vol. 529-530, No. 1). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.529-530.167