Comparing the dosimetric impact of interfractional anatomical changes in photon, proton and carbon ion radiotherapy for pancreatic cancer patients

Antonetta C. Houweling, Koen Crama, Jorrit Visser, Kyohei Fukata, Coen R.N. Rasch, Tatsuya Ohno, Arjan Bel, Astrid Van Der Horst

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Radiotherapy using charged particles is characterized by a low dose to the surrounding healthy organs, while delivering a high dose to the tumor. However, interfractional anatomical changes can greatly affect the robustness of particle therapy. Therefore, we compared the dosimetric impact of interfractional anatomical changes (i.e. body contour differences and gastrointestinal gas volume changes) in photon, proton and carbon ion therapy for pancreatic cancer patients. In this retrospective planning study, photon, proton and carbon ion treatment plans were created for 9 patients. Fraction dose calculations were performed using daily cone-beam CT (CBCT) images. To this end, the planning CT was deformably registered to each CBCT; gastrointestinal gas volumes were delineated on the CBCTs and copied to the deformed CT. Fraction doses were accumulated rigidly. To compare planned and accumulated dose, dosevolume histogram (DVH) parameters of the planned and accumulated dose of the different radiotherapy modalities were determined for the internal gross tumor volume, internal clinical target volume (iCTV) and organs-at-risk (OARs; duodenum, stomach, kidneys, liver and spinal cord). Photon plans were highly robust against interfractional anatomical changes. The difference between the planned and accumulated DVH parameters for the photon plans was less than 0.5% for the target and OARs. In both proton and carbon ion therapy, however, coverage of the iCTV was considerably.

Original languageEnglish
Pages (from-to)3051-3064
Number of pages14
JournalPhysics in Medicine and Biology
Volume62
Issue number8
DOIs
Publication statusPublished - 2017 Mar 21
Externally publishedYes

Fingerprint

Heavy Ion Radiotherapy
Pancreatic Neoplasms
Photons
Protons
Radiotherapy
Gases
Organs at Risk
Cone-Beam Computed Tomography
Tumor Burden
Duodenum
Spinal Cord
Stomach
Carbon
Retrospective Studies
Ions
Kidney
Liver
Therapeutics
Neoplasms

Keywords

  • anatomical changes
  • carbon ion
  • interfractional changes
  • pancreatic cancer
  • photon, proton
  • radiotherapy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Comparing the dosimetric impact of interfractional anatomical changes in photon, proton and carbon ion radiotherapy for pancreatic cancer patients. / Houweling, Antonetta C.; Crama, Koen; Visser, Jorrit; Fukata, Kyohei; Rasch, Coen R.N.; Ohno, Tatsuya; Bel, Arjan; Van Der Horst, Astrid.

In: Physics in Medicine and Biology, Vol. 62, No. 8, 21.03.2017, p. 3051-3064.

Research output: Contribution to journalArticle

Houweling, Antonetta C. ; Crama, Koen ; Visser, Jorrit ; Fukata, Kyohei ; Rasch, Coen R.N. ; Ohno, Tatsuya ; Bel, Arjan ; Van Der Horst, Astrid. / Comparing the dosimetric impact of interfractional anatomical changes in photon, proton and carbon ion radiotherapy for pancreatic cancer patients. In: Physics in Medicine and Biology. 2017 ; Vol. 62, No. 8. pp. 3051-3064.
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