Comparison between pial and intraparenchymal vascular responses to sympathetic stimulation under hypercapnic conditions. With special reference to the mechanism for escape phenomenon

Daisuke Uematsu, Fumio Gotoh, Yasuo Fukuuchi, Takahiro Amano, Norihiro Suzuki, Masahiro Kobari, Jun Kawamura, Nobuhiko Itoh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have shown that secondary vasodilation ('escape' phenomenon) during sympathetic nerve stimulation occurs in the intraparenchymal vessels but not remarkable in the pial vessels. To test a possible role of CO2 accumulation in the brain tissue in this phenomenon, the responses of pial and intraparenchymal vessels to sympathetic nerve stimulation were investigated during hypercapnia in 9 cats by using a video camera photoelectric system. The ipsilateral superior cervical ganglion was electrically stimulated for 5 min during hypercapnia (PaCO2 = 50 ± 2 mm Hg). The intraparenchymal vessels as well as pial vessels remained constricted throughout the stimulation. Secondary dilation of the intraparenchymal vessels as seen at the later stage of sympathetic stimulation during normocapnia was not observed under the hypercapnic conditions. We assume that the arterial CO2 tension was so high that the constriction of inflow vessels could not result in accumulation of CO2 in the brain parenchyma. The accumulation of chemical metabolites as represented by CO2 is therefore considered to be the most probable mechanism underlying the escape phenomenon of the intraparenchymal vessels.

Original languageEnglish
Pages (from-to)303-311
Number of pages9
JournalJournal of the Neurological Sciences
Volume78
Issue number3
DOIs
Publication statusPublished - 1987

Fingerprint

Hypercapnia
Blood Vessels
Superior Cervical Ganglion
Brain
Constriction
Vasodilation
Dilatation
Arterial Pressure
Cats

Keywords

  • Cerebral blood volume
  • Escape phenomenon
  • Hypercapnia
  • Pial vessel
  • Sympathetic stimulation

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Comparison between pial and intraparenchymal vascular responses to sympathetic stimulation under hypercapnic conditions. With special reference to the mechanism for escape phenomenon. / Uematsu, Daisuke; Gotoh, Fumio; Fukuuchi, Yasuo; Amano, Takahiro; Suzuki, Norihiro; Kobari, Masahiro; Kawamura, Jun; Itoh, Nobuhiko.

In: Journal of the Neurological Sciences, Vol. 78, No. 3, 1987, p. 303-311.

Research output: Contribution to journalArticle

Uematsu, Daisuke ; Gotoh, Fumio ; Fukuuchi, Yasuo ; Amano, Takahiro ; Suzuki, Norihiro ; Kobari, Masahiro ; Kawamura, Jun ; Itoh, Nobuhiko. / Comparison between pial and intraparenchymal vascular responses to sympathetic stimulation under hypercapnic conditions. With special reference to the mechanism for escape phenomenon. In: Journal of the Neurological Sciences. 1987 ; Vol. 78, No. 3. pp. 303-311.
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