Comparison of barium swallow, CT and thallium-201 SPECT in evaluating responses of patients with esophageal squamous cell carcinoma to preoperative chemoradiotherapy

Tadaki Nakahara, Takashi Togawa, Matsuo Nagata, Kazunori Kikuchi, Kazuo Hatano, Nobuharu Yui, Atsushi Kubo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aims of this study were to compare the results of thallium-201 (Tl-201) SPECT, barium swallow and CT in the assessment of the effect of preoperative chemoradiotherapy. This study consisted of 28 patients with advanced esophageal squamous cell carcinoma (AESCC) who underwent the three imaging modalities before and after preoperative chemoradiotherapy. The results were quantified using the bidimensional method for barium swallow and contrast-enhanced CT and the tumor-to-lung ratio for SPECT. The percent decrease in these quantitative values after therapy was defined as %Dba, %Dct and %Dtl respectively. The histological effect of the chemoradiotherapy was determined from the resected surgical specimen of the esophagus: grade 0, 100% viable tumor cells; grade 1a, 99-67%; grade 1b, 66-34%; grade 2, 33-1%; grade 3, no viable cells. A statistically significant difference of %Dtl between the subgroups of each grade was evident (p = 0.0433), whereas no significant differences were evident for %Dba (p = 0.1778) or %Dct (p = 0.7377). However, the overlap of %Dtl between these groups was marked. Although thallium-201 SPECT cannot be used to evaluate the therapeutic effect with acceptable accuracy, SPECT may be of additional value to barium swallow and CT in assessing the response of AESCC to preoperative chemoradiotherapy.

Original languageEnglish
Pages (from-to)583-591
Number of pages9
JournalAnnals of Nuclear Medicine
Volume17
Issue number7
Publication statusPublished - 2003 Oct

Fingerprint

Thallium
Chemoradiotherapy
Barium
Deglutition
Single-Photon Emission-Computed Tomography
Therapeutic Uses
Esophagus
Neoplasms
Lung
Esophageal Squamous Cell Carcinoma
Therapeutics

Keywords

  • Esophageal carcinoma
  • Preoperative chemoradiotherapy
  • SPECT
  • Thallium-201
  • Therapeutic effect

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Comparison of barium swallow, CT and thallium-201 SPECT in evaluating responses of patients with esophageal squamous cell carcinoma to preoperative chemoradiotherapy. / Nakahara, Tadaki; Togawa, Takashi; Nagata, Matsuo; Kikuchi, Kazunori; Hatano, Kazuo; Yui, Nobuharu; Kubo, Atsushi.

In: Annals of Nuclear Medicine, Vol. 17, No. 7, 10.2003, p. 583-591.

Research output: Contribution to journalArticle

Nakahara, Tadaki ; Togawa, Takashi ; Nagata, Matsuo ; Kikuchi, Kazunori ; Hatano, Kazuo ; Yui, Nobuharu ; Kubo, Atsushi. / Comparison of barium swallow, CT and thallium-201 SPECT in evaluating responses of patients with esophageal squamous cell carcinoma to preoperative chemoradiotherapy. In: Annals of Nuclear Medicine. 2003 ; Vol. 17, No. 7. pp. 583-591.
@article{0becd0ac636a47e18149599ee7e81c2f,
title = "Comparison of barium swallow, CT and thallium-201 SPECT in evaluating responses of patients with esophageal squamous cell carcinoma to preoperative chemoradiotherapy",
abstract = "The aims of this study were to compare the results of thallium-201 (Tl-201) SPECT, barium swallow and CT in the assessment of the effect of preoperative chemoradiotherapy. This study consisted of 28 patients with advanced esophageal squamous cell carcinoma (AESCC) who underwent the three imaging modalities before and after preoperative chemoradiotherapy. The results were quantified using the bidimensional method for barium swallow and contrast-enhanced CT and the tumor-to-lung ratio for SPECT. The percent decrease in these quantitative values after therapy was defined as {\%}Dba, {\%}Dct and {\%}Dtl respectively. The histological effect of the chemoradiotherapy was determined from the resected surgical specimen of the esophagus: grade 0, 100{\%} viable tumor cells; grade 1a, 99-67{\%}; grade 1b, 66-34{\%}; grade 2, 33-1{\%}; grade 3, no viable cells. A statistically significant difference of {\%}Dtl between the subgroups of each grade was evident (p = 0.0433), whereas no significant differences were evident for {\%}Dba (p = 0.1778) or {\%}Dct (p = 0.7377). However, the overlap of {\%}Dtl between these groups was marked. Although thallium-201 SPECT cannot be used to evaluate the therapeutic effect with acceptable accuracy, SPECT may be of additional value to barium swallow and CT in assessing the response of AESCC to preoperative chemoradiotherapy.",
keywords = "Esophageal carcinoma, Preoperative chemoradiotherapy, SPECT, Thallium-201, Therapeutic effect",
author = "Tadaki Nakahara and Takashi Togawa and Matsuo Nagata and Kazunori Kikuchi and Kazuo Hatano and Nobuharu Yui and Atsushi Kubo",
year = "2003",
month = "10",
language = "English",
volume = "17",
pages = "583--591",
journal = "Annals of Nuclear Medicine",
issn = "0914-7187",
publisher = "Springer Japan",
number = "7",

}

TY - JOUR

T1 - Comparison of barium swallow, CT and thallium-201 SPECT in evaluating responses of patients with esophageal squamous cell carcinoma to preoperative chemoradiotherapy

AU - Nakahara, Tadaki

AU - Togawa, Takashi

AU - Nagata, Matsuo

AU - Kikuchi, Kazunori

AU - Hatano, Kazuo

AU - Yui, Nobuharu

AU - Kubo, Atsushi

PY - 2003/10

Y1 - 2003/10

N2 - The aims of this study were to compare the results of thallium-201 (Tl-201) SPECT, barium swallow and CT in the assessment of the effect of preoperative chemoradiotherapy. This study consisted of 28 patients with advanced esophageal squamous cell carcinoma (AESCC) who underwent the three imaging modalities before and after preoperative chemoradiotherapy. The results were quantified using the bidimensional method for barium swallow and contrast-enhanced CT and the tumor-to-lung ratio for SPECT. The percent decrease in these quantitative values after therapy was defined as %Dba, %Dct and %Dtl respectively. The histological effect of the chemoradiotherapy was determined from the resected surgical specimen of the esophagus: grade 0, 100% viable tumor cells; grade 1a, 99-67%; grade 1b, 66-34%; grade 2, 33-1%; grade 3, no viable cells. A statistically significant difference of %Dtl between the subgroups of each grade was evident (p = 0.0433), whereas no significant differences were evident for %Dba (p = 0.1778) or %Dct (p = 0.7377). However, the overlap of %Dtl between these groups was marked. Although thallium-201 SPECT cannot be used to evaluate the therapeutic effect with acceptable accuracy, SPECT may be of additional value to barium swallow and CT in assessing the response of AESCC to preoperative chemoradiotherapy.

AB - The aims of this study were to compare the results of thallium-201 (Tl-201) SPECT, barium swallow and CT in the assessment of the effect of preoperative chemoradiotherapy. This study consisted of 28 patients with advanced esophageal squamous cell carcinoma (AESCC) who underwent the three imaging modalities before and after preoperative chemoradiotherapy. The results were quantified using the bidimensional method for barium swallow and contrast-enhanced CT and the tumor-to-lung ratio for SPECT. The percent decrease in these quantitative values after therapy was defined as %Dba, %Dct and %Dtl respectively. The histological effect of the chemoradiotherapy was determined from the resected surgical specimen of the esophagus: grade 0, 100% viable tumor cells; grade 1a, 99-67%; grade 1b, 66-34%; grade 2, 33-1%; grade 3, no viable cells. A statistically significant difference of %Dtl between the subgroups of each grade was evident (p = 0.0433), whereas no significant differences were evident for %Dba (p = 0.1778) or %Dct (p = 0.7377). However, the overlap of %Dtl between these groups was marked. Although thallium-201 SPECT cannot be used to evaluate the therapeutic effect with acceptable accuracy, SPECT may be of additional value to barium swallow and CT in assessing the response of AESCC to preoperative chemoradiotherapy.

KW - Esophageal carcinoma

KW - Preoperative chemoradiotherapy

KW - SPECT

KW - Thallium-201

KW - Therapeutic effect

UR - http://www.scopus.com/inward/record.url?scp=0242409594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242409594&partnerID=8YFLogxK

M3 - Article

C2 - 14651358

AN - SCOPUS:0242409594

VL - 17

SP - 583

EP - 591

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

SN - 0914-7187

IS - 7

ER -