Comparison of cerebral blood flow data obtained by computed tomography (CT) perfusion with that obtained by xenon CT using 320-row CT

Satoshi Takahashi, Yoshio Tanizaki, Hiroaki Kimura, Kazunori Akaji, Tadashige Kano, Kentaro Suzuki, Youhei Takayama, Takao Kanzawa, Satoka Shidoh, Masaki Nakazawa, Kazunari Yoshida, Ban Mihara

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Abstract

Cerebral blood flow (CBF) data obtained by computed tomography perfusion (CTP) imaging have been shown to be qualitative data rather than quantitative, in contrast with data obtained by other imaging methods, such as xenon CT (XeCT) imaging. Thus, interpatient comparisons of CBF values themselves obtained by CTP may be inaccurate. In this study, we have compared CBF ratios as well as CBF values obtained from CTP-CBF data to those obtained from XeCT-CBF data for the same patients to determine CTP-CBF parameters that can be used for interpatient comparisons. The data used in the present study were obtained as volume data using 320-row CT. The volume data were applied to an automated region of interest-determining software (3DSRT, version 3.5.2) and converted to 59 slices of 2 mm interval standardized images. In the present study, we reviewed 10 patients with occlusive cerebrovascular diseases (CVDs) undergoing both CTP and XeCT in the same period. Our study shows that ratios of CBF measurements, such as hemodynamic stress distribution (perforator-to-cortical flow ratio of middle cerebral artery [MCA] region) or the left/right ratio for the region of the MCA, calculated using CTP data have been shown to correlate well with the same ratios calculated using XeCT data. These results suggest that such CBF ratios could be useful for generating interpatient comparisons of CTP-CBF data obtained by 320-row CT among patients with occlusive CVD.

Original languageEnglish
Pages (from-to)635-641
Number of pages7
JournalJournal of Stroke and Cerebrovascular Diseases
Volume24
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

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Keywords

  • CT perfusion
  • Cerebral blood flow
  • automated ROI
  • hemodynamic stress distribution
  • xenon CT

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Takahashi, S., Tanizaki, Y., Kimura, H., Akaji, K., Kano, T., Suzuki, K., Takayama, Y., Kanzawa, T., Shidoh, S., Nakazawa, M., Yoshida, K., & Mihara, B. (2015). Comparison of cerebral blood flow data obtained by computed tomography (CT) perfusion with that obtained by xenon CT using 320-row CT. Journal of Stroke and Cerebrovascular Diseases, 24(3), 635-641. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.10.010