Comparison of clinical and radiological features of pneumocystis pneumonia between malignancy cases and acquired immunodeficiency syndrome cases

A multicenter study

Sadatomo Tasaka, Hitoshi Tokuda, Fumikazu Sakai, Takeshi Fujii, Kazuhiro Tateda, Takeshi Johkoh, Norio Ohmagari, Hiromitsu Ohta, Hideki Araoka, Yoshimi Kikuchi, Masahide Yasui, Kanako Inuzuka, Hajime Goto

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: The clinical features of pneumocystis pneumonia (PCP) differ according to the predisposing factors responsible for immunosuppression. Although PCP in patients with acquired immunodeficiency syndrome (AIDS) has been extensively described, its characteristics in non-AIDS patients, such as those with malignancies, are not thoroughly documented. Study objective: To characterize and compare the clinical and imaging features of PCP in patients with malignancies with those in AIDS patients. Design: A multi-center retrospective study. Patients and Measurements: We evaluated the clinical and radiological features of PCP in 21 patients with malignancies and in 17 with AIDS. Clinical presentation, serum markers, oxygenation, CT findings, and outcome were examined. Results: The patients with malignancies showed shorter durations of symptoms before PCP was diagnosed. The levels of serum markers and the oxygenation index did not differ. CT showed diffuse or widespread ground-glass opacity (GGO) in all of the patients evaluated. None of the AIDS patients demonstrated consolidation, whereas half of the patients with malignancy showed consolidation along with GGO. The extent of GGO scored on CT images was significantly greater in the AIDS patients. No correlation was observed between the CT findings and other clinical parameters. All of the AIDS patients recovered from PCP, whereas six patients with malignancies died within a month after the onset of PCP. Conclusion: The characteristics of the CT images differed between the patient groups with different underlying disorders, although it remains to be determined whether CT findings are associated with other clinical features or are predictive of the outcome of PCP.

Original languageEnglish
Pages (from-to)273-281
Number of pages9
JournalInternal Medicine
Volume49
Issue number4
DOIs
Publication statusPublished - 2010

Fingerprint

Pneumocystis Pneumonia
Multicenter Studies
Acquired Immunodeficiency Syndrome
Neoplasms
Glass
Biomarkers
Causality
Immunosuppression

Keywords

  • Acquired immunodeficiency syndrome
  • Computed tomography
  • Ground-glass opacity
  • Malignancy
  • Pneumocystis pneumonia

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Comparison of clinical and radiological features of pneumocystis pneumonia between malignancy cases and acquired immunodeficiency syndrome cases : A multicenter study. / Tasaka, Sadatomo; Tokuda, Hitoshi; Sakai, Fumikazu; Fujii, Takeshi; Tateda, Kazuhiro; Johkoh, Takeshi; Ohmagari, Norio; Ohta, Hiromitsu; Araoka, Hideki; Kikuchi, Yoshimi; Yasui, Masahide; Inuzuka, Kanako; Goto, Hajime.

In: Internal Medicine, Vol. 49, No. 4, 2010, p. 273-281.

Research output: Contribution to journalArticle

Tasaka, S, Tokuda, H, Sakai, F, Fujii, T, Tateda, K, Johkoh, T, Ohmagari, N, Ohta, H, Araoka, H, Kikuchi, Y, Yasui, M, Inuzuka, K & Goto, H 2010, 'Comparison of clinical and radiological features of pneumocystis pneumonia between malignancy cases and acquired immunodeficiency syndrome cases: A multicenter study', Internal Medicine, vol. 49, no. 4, pp. 273-281. https://doi.org/10.2169/internalmedicine.49.2871
Tasaka, Sadatomo ; Tokuda, Hitoshi ; Sakai, Fumikazu ; Fujii, Takeshi ; Tateda, Kazuhiro ; Johkoh, Takeshi ; Ohmagari, Norio ; Ohta, Hiromitsu ; Araoka, Hideki ; Kikuchi, Yoshimi ; Yasui, Masahide ; Inuzuka, Kanako ; Goto, Hajime. / Comparison of clinical and radiological features of pneumocystis pneumonia between malignancy cases and acquired immunodeficiency syndrome cases : A multicenter study. In: Internal Medicine. 2010 ; Vol. 49, No. 4. pp. 273-281.
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