Comparison of Cord Blood Transplantation with Unrelated Bone Marrow Transplantation in Patients Older than Fifty Years

Masatsugu Tanaka, Koichi Miyamura, Seitaro Terakura, Kiyotoshi Imai, Naoyuki Uchida, Hiroatsu Ago, Toru Sakura, Tetsuya Eto, Kazuteru Ohashi, Takahiro Fukuda, Shuichi Taniguchi, Shinichiro Mori, Tokiko Nagamura-Inoue, Yoshiko Atsuta, Shinichiro Okamoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We retrospectively compared the transplantation outcomes for patients 50 years or older who received umbilical cord blood transplantation (UCBT) with those who received unrelated bone marrow transplantation (UBMT) for hematologic malignancies. A total of 1377 patients who underwent transplantation between 2000 and 2009 were included: 516 received 8/8 HLA allele-matched UBMT, 295 received 7/8 HLA allele-matched UBMT, and 566 received 4/6 to 6/6 HLA-matched UCBT. Adjusted overall survival (OS) was significantly lower in those who underwent UCBT than those who underwent 8/8 HLA-matched UBMT but was similar to that of 7/8 HLA-matched UBMT (the 2-year OS after 8/8 HLA-matched UBMT, 7/8 HLA-matched UBMT, and UCBT were 49% [95% confidence interval (CI), 45% to 55%], 38% [95% CI, 32% to 45%], and 39% [95% CI, 34% to 43%], respectively). However, adjusted OS was similar between 8/8 HLA-matched UBMT and UCBT receiving ≥.84× 105 CD34+ cells/kg among those with acute myeloid leukemia and those with acute lymphoblastic leukemia (the 2-year OS was 49% [95% CI, 43% to 55%], and 49% [95% CI, 41% to 58%], respectively). These data suggest that UCB is a reasonable alternative donor/stem cell source for elderly patients with similar outcomes compared with UBM from 8/8 HLA-matched unrelated donors when the graft containing ≥.84× 105 CD34+ cells/kg is available.

Original languageEnglish
Pages (from-to)517-525
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

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Bone Marrow Transplantation
Fetal Blood
Transplantation
Confidence Intervals
Survival
Alleles
Unrelated Donors
Hematologic Neoplasms
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Stem Cells
Tissue Donors
Transplants

Keywords

  • Elderly patients
  • Umbilical cord blood transplantation
  • Unrelated bone marrow transplantation

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this

Comparison of Cord Blood Transplantation with Unrelated Bone Marrow Transplantation in Patients Older than Fifty Years. / Tanaka, Masatsugu; Miyamura, Koichi; Terakura, Seitaro; Imai, Kiyotoshi; Uchida, Naoyuki; Ago, Hiroatsu; Sakura, Toru; Eto, Tetsuya; Ohashi, Kazuteru; Fukuda, Takahiro; Taniguchi, Shuichi; Mori, Shinichiro; Nagamura-Inoue, Tokiko; Atsuta, Yoshiko; Okamoto, Shinichiro.

In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 3, 01.03.2015, p. 517-525.

Research output: Contribution to journalArticle

Tanaka, M, Miyamura, K, Terakura, S, Imai, K, Uchida, N, Ago, H, Sakura, T, Eto, T, Ohashi, K, Fukuda, T, Taniguchi, S, Mori, S, Nagamura-Inoue, T, Atsuta, Y & Okamoto, S 2015, 'Comparison of Cord Blood Transplantation with Unrelated Bone Marrow Transplantation in Patients Older than Fifty Years', Biology of Blood and Marrow Transplantation, vol. 21, no. 3, pp. 517-525. https://doi.org/10.1016/j.bbmt.2014.11.685
Tanaka, Masatsugu ; Miyamura, Koichi ; Terakura, Seitaro ; Imai, Kiyotoshi ; Uchida, Naoyuki ; Ago, Hiroatsu ; Sakura, Toru ; Eto, Tetsuya ; Ohashi, Kazuteru ; Fukuda, Takahiro ; Taniguchi, Shuichi ; Mori, Shinichiro ; Nagamura-Inoue, Tokiko ; Atsuta, Yoshiko ; Okamoto, Shinichiro. / Comparison of Cord Blood Transplantation with Unrelated Bone Marrow Transplantation in Patients Older than Fifty Years. In: Biology of Blood and Marrow Transplantation. 2015 ; Vol. 21, No. 3. pp. 517-525.
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