Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer

Katsushi Takebayashi, Yasuhiro Tsubosa, Satoru Matsuda, Keisuke Kawamorita, Masahiro Niihara, Takahiro Tsushima, Tomoya Yokota, Hiroshi Sato, Yusuke Onozawa, Hirofumi Ogawa, Tomoyuki Kamijo, Tetsuro Onitsuka, Masahiro Nakagawa, Hirofumi Yasui

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Esophagectomy and definitive chemoradiotherapy are recognized standard initial treatment modalities for cervical esophageal cancer. The goal of this study was to compare the treatment outcomes of curative surgery with those of chemoradiotherapy in patients who had potentially resectable tumor and who were candidates for surgery.We evaluated the data from 49 consecutive patients who were diagnosed with potentially resectable cervical esophageal cancer and who were deemed candidates for surgery. Thirteen patients were included in the surgery group, and 36 patients were included in chemoradiotherapy group. Baseline characteristics were balanced between the two groups. In the chemoradiotherapy group, the complete response rate was 58.3%. There was no significant difference in 5-year overall survival when comparing the surgery group and the chemoradiotherapy group (surgery, 60.6%; chemoradiotherapy, 51.4%; P=0.89). In the chemoradiotherapy group, of the 15 patients who failed to respond to initial treatment, 11 patients subsequently underwent salvage surgery. In conclusion, curative surgery and chemoradiotherapy as initial treatment for cervical esophageal cancer have comparable survival outcomes. Chemoradiotherapy should be selected as the initial larynx-preserving treatment for patients with cervical esophageal cancer although chemoradiotherapy non-responders require additional treatment, including salvage surgery.

Original languageEnglish
Article number12502
JournalDiseases of the Esophagus
Volume30
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1
Externally publishedYes

Fingerprint

Chemoradiotherapy
Esophageal Neoplasms
Uterine Cervical Neoplasms
Therapeutics
Salvage Therapy
Esophagectomy
Survival
Larynx

Keywords

  • Cancer esophagus
  • Cervical esophageal cancer
  • Chemoradiotherapy
  • Esophagectomy
  • Esophagus surgery
  • Salvage surgery

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer. / Takebayashi, Katsushi; Tsubosa, Yasuhiro; Matsuda, Satoru; Kawamorita, Keisuke; Niihara, Masahiro; Tsushima, Takahiro; Yokota, Tomoya; Sato, Hiroshi; Onozawa, Yusuke; Ogawa, Hirofumi; Kamijo, Tomoyuki; Onitsuka, Tetsuro; Nakagawa, Masahiro; Yasui, Hirofumi.

In: Diseases of the Esophagus, Vol. 30, No. 2, 12502, 01.02.2017.

Research output: Contribution to journalArticle

Takebayashi, K, Tsubosa, Y, Matsuda, S, Kawamorita, K, Niihara, M, Tsushima, T, Yokota, T, Sato, H, Onozawa, Y, Ogawa, H, Kamijo, T, Onitsuka, T, Nakagawa, M & Yasui, H 2017, 'Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer', Diseases of the Esophagus, vol. 30, no. 2, 12502. https://doi.org/10.1111/dote.12502
Takebayashi, Katsushi ; Tsubosa, Yasuhiro ; Matsuda, Satoru ; Kawamorita, Keisuke ; Niihara, Masahiro ; Tsushima, Takahiro ; Yokota, Tomoya ; Sato, Hiroshi ; Onozawa, Yusuke ; Ogawa, Hirofumi ; Kamijo, Tomoyuki ; Onitsuka, Tetsuro ; Nakagawa, Masahiro ; Yasui, Hirofumi. / Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer. In: Diseases of the Esophagus. 2017 ; Vol. 30, No. 2.
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