Comparison of effects of low dose of spironolactone and a thiazide diuretic in patients with hypertension treated with an angiotensin-converting enzyme inhibitor or an angiotensin type 1 receptor blocker

Miyashita Yutaka, Mizuo Mifune, Eiji Kubota, Hiroshi Itoh, Ikuo Saito

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study was performed to investigate the additional anti-hypertensive effects and safety of low-dose thiazide diuretic, trichlormethiazide (TCTZ), and a mineralocorticoid receptor blocker, spironolactone (SPI), as add-on therapy in 64 patients whose blood pressure (BP) at office were over 14090 mmHg, while receiving anti-hypertensive medication including an angiotensin-converting enzyme inhibitor or angiotensin II type I receptor antagonist. After 6 months, we observed a decrease of office and home BP. Moreover, urinary albumin excretion (UAE) was reduced in SPI-treated group, but not in the TCTZ-treated group. No significant change in serum potassium, lipids, glucose, or uric acid was observed. In conclusion, low-dose thiazide diuretic or SPI provided a significant additional anti-hypertensive effect in patients in whom hypertension was not controlled by medication, and SPI-reduced UAE.

Original languageEnglish
Pages (from-to)648-656
Number of pages9
JournalClinical and Experimental Hypertension
Volume31
Issue number8
DOIs
Publication statusPublished - 2009 Dec

Keywords

  • Hypertension
  • Spironolactone
  • Thiazide diuretics

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Fingerprint Dive into the research topics of 'Comparison of effects of low dose of spironolactone and a thiazide diuretic in patients with hypertension treated with an angiotensin-converting enzyme inhibitor or an angiotensin type 1 receptor blocker'. Together they form a unique fingerprint.

  • Cite this