Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan

Ryu Ishihara, Hiroyasu Iishi, Noriya Uedo, Yoji Takeuchi, Sachiko Yamamoto, Takuya Yamada, Eriko Masuda, Koji Higashino, Motohiko Kato, Hiroyuki Narahara, Masaharu Tatsuta

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

Background: EMR and endoscopic submucosal dissection (ESD) are now being increasingly used for the treatment of esophageal cancers. However, their efficacies in smaller lesions have not been compared. Objective: For effective use of these methods, we compared the results of ESD and 2 major EMR methods for treating esophageal cancers of ≤20 mm. Design: A retrospective study. Setting: A cancer-referral center. Patients: A total of 136 patients with 171 lesions ≤20 mm who presented between January 2002 and October 2007 were enrolled. Main Outcome Measurements: En bloc and curative resection. Results: Of the 171 lesions, 168 were squamous-cell carcinoma and 3 were adenocarcinoma. The en bloc resection rates decreased in the order of ESD (100%), EMR using a transparent cap (EMRC) (87%), and 2-channel EMR (71%). However, the differences showed only marginal significance. The curative resection rate of ESD (97%) was significantly higher than those of the other 2 methods. Furthermore, the curative resection rate of EMRC (71%) was significantly higher than that of 2-channel EMR (46%). In lesions <15 mm, the en bloc and curative resection rates were significantly higher for EMRC (100% and 86%, respectively) than 2-channel EMR (86% and 51%, respectively), whereas no significant differences were found between the en bloc and curative resection rates of EMRC and ESD. There were no differences in the complication rates. Limitations: A single-center, retrospective analysis. Conclusions: ESD was found to be the best endoscopic resection method, even for smaller esophageal cancers. EMRC would be a good alternative to ESD for lesions <15 mm.

Original languageEnglish
Pages (from-to)1066-1072
Number of pages7
JournalGastrointestinal Endoscopy
Volume68
Issue number6
DOIs
Publication statusPublished - 2008 Dec 1
Externally publishedYes

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Esophageal Neoplasms
Japan
Endoscopic Mucosal Resection
Squamous Cell Carcinoma
Adenocarcinoma
Referral and Consultation
Retrospective Studies
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Ishihara, R., Iishi, H., Uedo, N., Takeuchi, Y., Yamamoto, S., Yamada, T., ... Tatsuta, M. (2008). Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan. Gastrointestinal Endoscopy, 68(6), 1066-1072. https://doi.org/10.1016/j.gie.2008.03.1114

Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan. / Ishihara, Ryu; Iishi, Hiroyasu; Uedo, Noriya; Takeuchi, Yoji; Yamamoto, Sachiko; Yamada, Takuya; Masuda, Eriko; Higashino, Koji; Kato, Motohiko; Narahara, Hiroyuki; Tatsuta, Masaharu.

In: Gastrointestinal Endoscopy, Vol. 68, No. 6, 01.12.2008, p. 1066-1072.

Research output: Contribution to journalArticle

Ishihara, R, Iishi, H, Uedo, N, Takeuchi, Y, Yamamoto, S, Yamada, T, Masuda, E, Higashino, K, Kato, M, Narahara, H & Tatsuta, M 2008, 'Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan', Gastrointestinal Endoscopy, vol. 68, no. 6, pp. 1066-1072. https://doi.org/10.1016/j.gie.2008.03.1114
Ishihara, Ryu ; Iishi, Hiroyasu ; Uedo, Noriya ; Takeuchi, Yoji ; Yamamoto, Sachiko ; Yamada, Takuya ; Masuda, Eriko ; Higashino, Koji ; Kato, Motohiko ; Narahara, Hiroyuki ; Tatsuta, Masaharu. / Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan. In: Gastrointestinal Endoscopy. 2008 ; Vol. 68, No. 6. pp. 1066-1072.
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T1 - Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan

AU - Ishihara, Ryu

AU - Iishi, Hiroyasu

AU - Uedo, Noriya

AU - Takeuchi, Yoji

AU - Yamamoto, Sachiko

AU - Yamada, Takuya

AU - Masuda, Eriko

AU - Higashino, Koji

AU - Kato, Motohiko

AU - Narahara, Hiroyuki

AU - Tatsuta, Masaharu

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Background: EMR and endoscopic submucosal dissection (ESD) are now being increasingly used for the treatment of esophageal cancers. However, their efficacies in smaller lesions have not been compared. Objective: For effective use of these methods, we compared the results of ESD and 2 major EMR methods for treating esophageal cancers of ≤20 mm. Design: A retrospective study. Setting: A cancer-referral center. Patients: A total of 136 patients with 171 lesions ≤20 mm who presented between January 2002 and October 2007 were enrolled. Main Outcome Measurements: En bloc and curative resection. Results: Of the 171 lesions, 168 were squamous-cell carcinoma and 3 were adenocarcinoma. The en bloc resection rates decreased in the order of ESD (100%), EMR using a transparent cap (EMRC) (87%), and 2-channel EMR (71%). However, the differences showed only marginal significance. The curative resection rate of ESD (97%) was significantly higher than those of the other 2 methods. Furthermore, the curative resection rate of EMRC (71%) was significantly higher than that of 2-channel EMR (46%). In lesions <15 mm, the en bloc and curative resection rates were significantly higher for EMRC (100% and 86%, respectively) than 2-channel EMR (86% and 51%, respectively), whereas no significant differences were found between the en bloc and curative resection rates of EMRC and ESD. There were no differences in the complication rates. Limitations: A single-center, retrospective analysis. Conclusions: ESD was found to be the best endoscopic resection method, even for smaller esophageal cancers. EMRC would be a good alternative to ESD for lesions <15 mm.

AB - Background: EMR and endoscopic submucosal dissection (ESD) are now being increasingly used for the treatment of esophageal cancers. However, their efficacies in smaller lesions have not been compared. Objective: For effective use of these methods, we compared the results of ESD and 2 major EMR methods for treating esophageal cancers of ≤20 mm. Design: A retrospective study. Setting: A cancer-referral center. Patients: A total of 136 patients with 171 lesions ≤20 mm who presented between January 2002 and October 2007 were enrolled. Main Outcome Measurements: En bloc and curative resection. Results: Of the 171 lesions, 168 were squamous-cell carcinoma and 3 were adenocarcinoma. The en bloc resection rates decreased in the order of ESD (100%), EMR using a transparent cap (EMRC) (87%), and 2-channel EMR (71%). However, the differences showed only marginal significance. The curative resection rate of ESD (97%) was significantly higher than those of the other 2 methods. Furthermore, the curative resection rate of EMRC (71%) was significantly higher than that of 2-channel EMR (46%). In lesions <15 mm, the en bloc and curative resection rates were significantly higher for EMRC (100% and 86%, respectively) than 2-channel EMR (86% and 51%, respectively), whereas no significant differences were found between the en bloc and curative resection rates of EMRC and ESD. There were no differences in the complication rates. Limitations: A single-center, retrospective analysis. Conclusions: ESD was found to be the best endoscopic resection method, even for smaller esophageal cancers. EMRC would be a good alternative to ESD for lesions <15 mm.

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