Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations

Hakumei Oh, Fausto R. Loberiza, Mei Jie Zhang, Olle Ringdén, Hideki Akiyama, Takayoshi Asai, Shuichi Miyawaki, Shinichiro Okamoto, Mary M. Horowitz, Joseph H. Antin, Asad Bashey, Jennifer M. Bird, Matthew H. Carabasi, Joseph W. Fay, Robert Peter Gale, Roger H. Giller, John M. Goldman, Gregory A. Hale, Richard E. Harris, Jean Henslee-DowneyHans Jochem Kolb, Mark R. Litzow, Philip L. McCarthy, Steven M. Neudorf, Derek S. Serna, Gerard Socié, Pierre Tiberghien, A. John Barrett

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Abstract

The association of ethinicity with the incidence of graft-versus-host disease (GVHD) and other clinical outcomes after transplantation is controversial. We compared the results of HLA-identical sibling bone marrow transplantations for leukemia, performed between 1990 and 1999, among different ethnic populations, including 562 Japanese, 829 white Americans, 71 African Americans, 195 Scandinavians, and 95 Irish. Results for adults and children were analyzed separately. Multivariate analyses of adult patients showed that white Americans, African Americans, and Irish cohorts were at significantly higher risk for acute GVHD than Japanese or Scandinavian cohorts (relative risk [RR] = 1.77, P < .001; RR = 1.84, P < .006; RR = 2.22, P < .001, respectively). White Americans, African Americans, and Irish, but not Scandinavians, were at significantly higher risk for early (within 3 months of transplantation) transplant-related mortality (TRM) compared with Japanese (RR = 2.99, P < .001; RR = 5.88, P < .001; RR = 2.66, P < .009, respectively). No differences in the risk for chronic GVHD, relapse, and overall survival were noted. In the pediatric cohort (limited to Japanese and white Americans), white Americans were at significantly higher risk for acute (RR = 1.93; P = .04) and chronic (RR = 3.16; P = .002) GVHD. No differences in other clinical outcomes were noted. Our findings suggest that ethnicity may influence the risk for GVHD, though overall survival rates after transplantation remain similar.

Original languageEnglish
Pages (from-to)1408-1416
Number of pages9
JournalBlood
Volume105
Issue number4
DOIs
Publication statusPublished - 2005 Feb 15
Externally publishedYes

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Graft vs Host Disease
Bone Marrow Transplantation
Grafts
Siblings
Bone
Survival
Population
African Americans
Transplantation (surgical)
Transplantation
Transplants
Pediatrics
Leukemia
Multivariate Analysis
Survival Rate

ASJC Scopus subject areas

  • Hematology

Cite this

Oh, H., Loberiza, F. R., Zhang, M. J., Ringdén, O., Akiyama, H., Asai, T., ... Barrett, A. J. (2005). Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations. Blood, 105(4), 1408-1416. https://doi.org/10.1182/blood-2004-06-2385

Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations. / Oh, Hakumei; Loberiza, Fausto R.; Zhang, Mei Jie; Ringdén, Olle; Akiyama, Hideki; Asai, Takayoshi; Miyawaki, Shuichi; Okamoto, Shinichiro; Horowitz, Mary M.; Antin, Joseph H.; Bashey, Asad; Bird, Jennifer M.; Carabasi, Matthew H.; Fay, Joseph W.; Gale, Robert Peter; Giller, Roger H.; Goldman, John M.; Hale, Gregory A.; Harris, Richard E.; Henslee-Downey, Jean; Kolb, Hans Jochem; Litzow, Mark R.; McCarthy, Philip L.; Neudorf, Steven M.; Serna, Derek S.; Socié, Gerard; Tiberghien, Pierre; Barrett, A. John.

In: Blood, Vol. 105, No. 4, 15.02.2005, p. 1408-1416.

Research output: Contribution to journalArticle

Oh, H, Loberiza, FR, Zhang, MJ, Ringdén, O, Akiyama, H, Asai, T, Miyawaki, S, Okamoto, S, Horowitz, MM, Antin, JH, Bashey, A, Bird, JM, Carabasi, MH, Fay, JW, Gale, RP, Giller, RH, Goldman, JM, Hale, GA, Harris, RE, Henslee-Downey, J, Kolb, HJ, Litzow, MR, McCarthy, PL, Neudorf, SM, Serna, DS, Socié, G, Tiberghien, P & Barrett, AJ 2005, 'Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations', Blood, vol. 105, no. 4, pp. 1408-1416. https://doi.org/10.1182/blood-2004-06-2385
Oh, Hakumei ; Loberiza, Fausto R. ; Zhang, Mei Jie ; Ringdén, Olle ; Akiyama, Hideki ; Asai, Takayoshi ; Miyawaki, Shuichi ; Okamoto, Shinichiro ; Horowitz, Mary M. ; Antin, Joseph H. ; Bashey, Asad ; Bird, Jennifer M. ; Carabasi, Matthew H. ; Fay, Joseph W. ; Gale, Robert Peter ; Giller, Roger H. ; Goldman, John M. ; Hale, Gregory A. ; Harris, Richard E. ; Henslee-Downey, Jean ; Kolb, Hans Jochem ; Litzow, Mark R. ; McCarthy, Philip L. ; Neudorf, Steven M. ; Serna, Derek S. ; Socié, Gerard ; Tiberghien, Pierre ; Barrett, A. John. / Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations. In: Blood. 2005 ; Vol. 105, No. 4. pp. 1408-1416.
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abstract = "The association of ethinicity with the incidence of graft-versus-host disease (GVHD) and other clinical outcomes after transplantation is controversial. We compared the results of HLA-identical sibling bone marrow transplantations for leukemia, performed between 1990 and 1999, among different ethnic populations, including 562 Japanese, 829 white Americans, 71 African Americans, 195 Scandinavians, and 95 Irish. Results for adults and children were analyzed separately. Multivariate analyses of adult patients showed that white Americans, African Americans, and Irish cohorts were at significantly higher risk for acute GVHD than Japanese or Scandinavian cohorts (relative risk [RR] = 1.77, P < .001; RR = 1.84, P < .006; RR = 2.22, P < .001, respectively). White Americans, African Americans, and Irish, but not Scandinavians, were at significantly higher risk for early (within 3 months of transplantation) transplant-related mortality (TRM) compared with Japanese (RR = 2.99, P < .001; RR = 5.88, P < .001; RR = 2.66, P < .009, respectively). No differences in the risk for chronic GVHD, relapse, and overall survival were noted. In the pediatric cohort (limited to Japanese and white Americans), white Americans were at significantly higher risk for acute (RR = 1.93; P = .04) and chronic (RR = 3.16; P = .002) GVHD. No differences in other clinical outcomes were noted. Our findings suggest that ethnicity may influence the risk for GVHD, though overall survival rates after transplantation remain similar.",
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AU - Oh, Hakumei

AU - Loberiza, Fausto R.

AU - Zhang, Mei Jie

AU - Ringdén, Olle

AU - Akiyama, Hideki

AU - Asai, Takayoshi

AU - Miyawaki, Shuichi

AU - Okamoto, Shinichiro

AU - Horowitz, Mary M.

AU - Antin, Joseph H.

AU - Bashey, Asad

AU - Bird, Jennifer M.

AU - Carabasi, Matthew H.

AU - Fay, Joseph W.

AU - Gale, Robert Peter

AU - Giller, Roger H.

AU - Goldman, John M.

AU - Hale, Gregory A.

AU - Harris, Richard E.

AU - Henslee-Downey, Jean

AU - Kolb, Hans Jochem

AU - Litzow, Mark R.

AU - McCarthy, Philip L.

AU - Neudorf, Steven M.

AU - Serna, Derek S.

AU - Socié, Gerard

AU - Tiberghien, Pierre

AU - Barrett, A. John

PY - 2005/2/15

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N2 - The association of ethinicity with the incidence of graft-versus-host disease (GVHD) and other clinical outcomes after transplantation is controversial. We compared the results of HLA-identical sibling bone marrow transplantations for leukemia, performed between 1990 and 1999, among different ethnic populations, including 562 Japanese, 829 white Americans, 71 African Americans, 195 Scandinavians, and 95 Irish. Results for adults and children were analyzed separately. Multivariate analyses of adult patients showed that white Americans, African Americans, and Irish cohorts were at significantly higher risk for acute GVHD than Japanese or Scandinavian cohorts (relative risk [RR] = 1.77, P < .001; RR = 1.84, P < .006; RR = 2.22, P < .001, respectively). White Americans, African Americans, and Irish, but not Scandinavians, were at significantly higher risk for early (within 3 months of transplantation) transplant-related mortality (TRM) compared with Japanese (RR = 2.99, P < .001; RR = 5.88, P < .001; RR = 2.66, P < .009, respectively). No differences in the risk for chronic GVHD, relapse, and overall survival were noted. In the pediatric cohort (limited to Japanese and white Americans), white Americans were at significantly higher risk for acute (RR = 1.93; P = .04) and chronic (RR = 3.16; P = .002) GVHD. No differences in other clinical outcomes were noted. Our findings suggest that ethnicity may influence the risk for GVHD, though overall survival rates after transplantation remain similar.

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