Comparison of meniscal extrusion and osteophyte formation at the intercondylar notch as a predictive biomarker for incidence of knee osteoarthritis-Data from the Osteoarthritis Initiative-

Kentaro Okada, Satoshi Yamaguchi, Yasunori Sato, Takahiro Enomoto, Yuya Ogawa, Seiji Ohtori, Masamichi Tahara, Takahisa Sasho

Research output: Contribution to journalArticle

Abstract

Background: Medial meniscal extrusion (ME) is a biomarker to predict later development of knee osteoarthritis (KOA). On the other hand, we have reported osteophyte formation at the posterior condylar notch of the femur served as a biomarker for the same purpose. The purpose of this study is to compare capacity of the two biomarkers in predicting KOA development. Methods: Two cohort of knees were established utilizing publicly available data from the Osteoarthritis Initiative (OAI). No OA group (NOA) consisted of knees that were grade 0 or 1 on Kellgren and Lawrence grade (K/L) both at baseline and 48 months later, and pre-radiographic-OA group (PROA) consisted of knees that were grade 0 or 1 at baseline but grade ≥2 48 months later. Baseline MR images were evaluated in terms of ME and osteophyte formation at the posterior condylar notch. ME was evaluated both by meniscus subluxation index (MSI) indicating the ratio of the extruded width of the medial meniscus to the width of medial meniscal body and by the medial radial displacement (MRD) indicating actual extruded width. The size of the osteophyte was assessed using a semi-quantitative whole-organ magnetic resonance imaging score (WORMS). The predictive accuracy of KOA was assessed by the area under the receiver operating characteristic curve (AUC) and optimal cutoff was determined for each parameter. Results: The AUC for MSI was 0.654 (0.561–0.748: 95% CI) and the cutoff value was determined as 17%. That for MRD was 0.677 (0.584–0.770) and the cutoff value was 2.2 mm. The AUC for the WORMS score at the posterior condylar notch was 0.667 (0.579–0.756) and the cutoff value was 2. Conclusions: Similar predicting capacity of KOA development was found both in ME and osteophyte formation at the posterior condylar notch. Using these simple parameter, mas-screening for KOA development would be possible.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalJournal of Orthopaedic Science
Volume24
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1
Externally publishedYes

Fingerprint

Osteophyte
Knee Osteoarthritis
Osteoarthritis
Biomarkers
Incidence
Area Under Curve
Knee
Magnetic Resonance Imaging
Tibial Meniscus
ROC Curve
Femur

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Comparison of meniscal extrusion and osteophyte formation at the intercondylar notch as a predictive biomarker for incidence of knee osteoarthritis-Data from the Osteoarthritis Initiative-. / Okada, Kentaro; Yamaguchi, Satoshi; Sato, Yasunori; Enomoto, Takahiro; Ogawa, Yuya; Ohtori, Seiji; Tahara, Masamichi; Sasho, Takahisa.

In: Journal of Orthopaedic Science, Vol. 24, No. 1, 01.01.2019, p. 121-127.

Research output: Contribution to journalArticle

Okada, Kentaro ; Yamaguchi, Satoshi ; Sato, Yasunori ; Enomoto, Takahiro ; Ogawa, Yuya ; Ohtori, Seiji ; Tahara, Masamichi ; Sasho, Takahisa. / Comparison of meniscal extrusion and osteophyte formation at the intercondylar notch as a predictive biomarker for incidence of knee osteoarthritis-Data from the Osteoarthritis Initiative-. In: Journal of Orthopaedic Science. 2019 ; Vol. 24, No. 1. pp. 121-127.
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T1 - Comparison of meniscal extrusion and osteophyte formation at the intercondylar notch as a predictive biomarker for incidence of knee osteoarthritis-Data from the Osteoarthritis Initiative-

AU - Okada, Kentaro

AU - Yamaguchi, Satoshi

AU - Sato, Yasunori

AU - Enomoto, Takahiro

AU - Ogawa, Yuya

AU - Ohtori, Seiji

AU - Tahara, Masamichi

AU - Sasho, Takahisa

PY - 2019/1/1

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