TY - JOUR
T1 - Comparison of oncological safety between nipple sparing mastectomy and total mastectomy using propensity score matching
AU - Seki, T.
AU - Jinno, Hiromitsu
AU - Okabayashi, K.
AU - Murata, T.
AU - Matsumoto, A.
AU - Takahashi, M.
AU - Hayashida, T.
AU - Kitagawa, Y.
PY - 2015
Y1 - 2015
N2 - INTRODCUTION Although nipple sparing mastectomy (NSM) has attracted increased recognition as an alternative to traditional mastectomy approaches, its oncological safety is unclear. The purpose of this study was to compare the local recurrence rate between NSM and total mastectomy (TM). METHODS: Between 2003 and 2013, 121 and 557 patients with stage 0-III breast cancer underwent NSM and TM respectively. Multivariate Cox regression and propensity score models were used to compare the two groups. RESULTS: There was no significant difference in the five-year local recurrence rate between the NSM and TM groups (7.6% vs 4.9%, p=0.398). In multivariate analysis, NSM was not a risk factor for local recurrence (hazard ratio: 1.653, 95% confidence interval: 0.586-4.663, p=0.343). Propensity score matching found similar five-year local recurrence free survival rates between the two groups (92.3% vs 93.7%, p=0.655). CONCLUSIONS: Our results suggest that NSM may provide oncological safety comparable with mastectomy for carefully selected patients.
AB - INTRODCUTION Although nipple sparing mastectomy (NSM) has attracted increased recognition as an alternative to traditional mastectomy approaches, its oncological safety is unclear. The purpose of this study was to compare the local recurrence rate between NSM and total mastectomy (TM). METHODS: Between 2003 and 2013, 121 and 557 patients with stage 0-III breast cancer underwent NSM and TM respectively. Multivariate Cox regression and propensity score models were used to compare the two groups. RESULTS: There was no significant difference in the five-year local recurrence rate between the NSM and TM groups (7.6% vs 4.9%, p=0.398). In multivariate analysis, NSM was not a risk factor for local recurrence (hazard ratio: 1.653, 95% confidence interval: 0.586-4.663, p=0.343). Propensity score matching found similar five-year local recurrence free survival rates between the two groups (92.3% vs 93.7%, p=0.655). CONCLUSIONS: Our results suggest that NSM may provide oncological safety comparable with mastectomy for carefully selected patients.
KW - Breast cancer
KW - Nipple sparing mastectomy
KW - Propensity score matching
UR - http://www.scopus.com/inward/record.url?scp=84929757054&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929757054&partnerID=8YFLogxK
U2 - 10.1308/003588415X14181254788881
DO - 10.1308/003588415X14181254788881
M3 - Article
C2 - 26263938
AN - SCOPUS:84929757054
SN - 0035-8843
VL - 97
SP - 291
EP - 297
JO - Annals of the Royal College of Surgeons of England
JF - Annals of the Royal College of Surgeons of England
IS - 4
ER -
