Comparison of outcomes after allogeneic hematopoietic stem cell transplantation in patients with follicular lymphoma, diffuse large B-cell lymphoma associated with follicular lymphoma, or de novo diffuse large B-cell lymphoma

Kohei Tada, Sung Won Kim, Yoshitaka Asakura, Nobuhiro Hiramoto, Kimikazu Yakushijin, Saiko Kurosawa, Kinuko Tajima, Shin ichiro Mori, Yuji Heike, Ryuji Tanosaki, Akiko Miyagi Maeshima, Hirokazu Taniguchi, Koh Furuta, Yoshikazu Kagami, Yoshihiro Matsuno, Kensei Tobinai, Yoichi Takaue, Takahiro Fukuda

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11 Citations (Scopus)

Abstract

The outcome after allogeneic hematopoietic stem cell transplantation (allo-HCT) for diffuse large B-cell lymphoma (DLBCL) associated with follicular lymphoma (FL), which includes DLBCL with pre- or co-existing FL, remains controversial, and few previous reports have compared the outcomes after allo-HCT for FL, DLBCL associated with FL, and de novo DLBCL. We retrospectively analyzed 97 consecutive patients with FL (n = 46), DLBCL associated with FL (n = 22), or de novo DLBCL (n = 29) who received allo-HCT at our institute between 2000 and 2010. With a median follow-up of 53 months, the 5-year overall survival (OS) and progression-free survival (PFS) were, respectively, 77% and 70% for FL, 62% and 57% for DLBCL associated with FL, and 26% and 23% for de novo DLBCL. The 5-year cumulative incidences of non-relapse mortality and disease progression/relapse were, respectively, 16% and 15% for FL, 19% and 24% for DLBCL associated with FL, and 36% and 41% for de novo DLBCL. By a multivariate analysis, the OS and PFS for DLBCL associated with FL were significantly better than those for de novo DLBCL, whereas they were not significantly different from those for FL. These results suggest that allo-HCT may be a promising option for patients with not only advanced FL but also DLBCL associated with FL.

Original languageEnglish
Pages (from-to)770-775
Number of pages6
JournalAmerican journal of hematology
Volume87
Issue number8
DOIs
Publication statusPublished - 2012 Aug

ASJC Scopus subject areas

  • Hematology

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    Tada, K., Kim, S. W., Asakura, Y., Hiramoto, N., Yakushijin, K., Kurosawa, S., Tajima, K., Mori, S. I., Heike, Y., Tanosaki, R., Maeshima, A. M., Taniguchi, H., Furuta, K., Kagami, Y., Matsuno, Y., Tobinai, K., Takaue, Y., & Fukuda, T. (2012). Comparison of outcomes after allogeneic hematopoietic stem cell transplantation in patients with follicular lymphoma, diffuse large B-cell lymphoma associated with follicular lymphoma, or de novo diffuse large B-cell lymphoma. American journal of hematology, 87(8), 770-775. https://doi.org/10.1002/ajh.23246