Comparison of Outcomes of Women Versus Men With Non–ST-elevation Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention (from the Japanese Nationwide Registry)

Yohei Numasawa, Taku Inohara, Hideki Ishii, Toshiki Kuno, Masaki Kodaira, Shun Kosaka, Kenshi Fujii, Shiro Uemura, Tetsuya Amano, Kazushige Kadota, Masato Nakamura

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Previous studies have reported that women have worse outcomes than men after percutaneous coronary intervention (PCI), especially in patients with ST-elevation myocardial infarction. However, gender-related differences in patients with non–ST-elevation acute coronary syndromes (NSTE-ACS) have not been thoroughly investigated. In the Japanese nationwide registry, a total of 43,239 patients with NSTE-ACS from 861 hospitals underwent PCI in 2014. Overall, 11,326 patients (26.2%) were women. The women were older (75.0 ± 10.3 vs 68.7 ± 11.4 years, p <0.001) and had a higher prevalence of hypertension (p <0.001), hyperlipidemia (p = 0.003), and heart failure (p <0.001) compared with men. For inpatient outcomes, women had a higher rate of overall complications (3.3% vs 2.4%, p <0.001) and bleeding complications that required blood transfusion (0.6% vs 0.2%, p <0.001). On multivariate analysis, female gender was an independent predictor of overall (odds ratio [OR] 1.20, 95% CI 1.04 to 1.38; p = 0.011) and bleeding complications (OR 1.94, 95% CI 1.35 to 2.79; p <0.001) after adjustment but was not associated with in-hospital mortality (OR 1.05, 95% CI 0.79 to 1.40; p = 0.747). In conclusion, in patients with NSTE-ACS who underwent PCI, women were at greater risk than men for in-hospital complications, especially in bleeding complications.

Original languageEnglish
Pages (from-to)826-831
Number of pages6
JournalAmerican Journal of Cardiology
Volume119
Issue number6
DOIs
Publication statusPublished - 2017 Mar 15

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Percutaneous Coronary Intervention
Acute Coronary Syndrome
Registries
Odds Ratio
Hemorrhage
Hospital Mortality
Hyperlipidemias
Blood Transfusion
Inpatients
Multivariate Analysis
Heart Failure
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of Outcomes of Women Versus Men With Non–ST-elevation Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention (from the Japanese Nationwide Registry). / Numasawa, Yohei; Inohara, Taku; Ishii, Hideki; Kuno, Toshiki; Kodaira, Masaki; Kosaka, Shun; Fujii, Kenshi; Uemura, Shiro; Amano, Tetsuya; Kadota, Kazushige; Nakamura, Masato.

In: American Journal of Cardiology, Vol. 119, No. 6, 15.03.2017, p. 826-831.

Research output: Contribution to journalArticle

Numasawa, Yohei ; Inohara, Taku ; Ishii, Hideki ; Kuno, Toshiki ; Kodaira, Masaki ; Kosaka, Shun ; Fujii, Kenshi ; Uemura, Shiro ; Amano, Tetsuya ; Kadota, Kazushige ; Nakamura, Masato. / Comparison of Outcomes of Women Versus Men With Non–ST-elevation Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention (from the Japanese Nationwide Registry). In: American Journal of Cardiology. 2017 ; Vol. 119, No. 6. pp. 826-831.
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abstract = "Previous studies have reported that women have worse outcomes than men after percutaneous coronary intervention (PCI), especially in patients with ST-elevation myocardial infarction. However, gender-related differences in patients with non–ST-elevation acute coronary syndromes (NSTE-ACS) have not been thoroughly investigated. In the Japanese nationwide registry, a total of 43,239 patients with NSTE-ACS from 861 hospitals underwent PCI in 2014. Overall, 11,326 patients (26.2{\%}) were women. The women were older (75.0 ± 10.3 vs 68.7 ± 11.4 years, p <0.001) and had a higher prevalence of hypertension (p <0.001), hyperlipidemia (p = 0.003), and heart failure (p <0.001) compared with men. For inpatient outcomes, women had a higher rate of overall complications (3.3{\%} vs 2.4{\%}, p <0.001) and bleeding complications that required blood transfusion (0.6{\%} vs 0.2{\%}, p <0.001). On multivariate analysis, female gender was an independent predictor of overall (odds ratio [OR] 1.20, 95{\%} CI 1.04 to 1.38; p = 0.011) and bleeding complications (OR 1.94, 95{\%} CI 1.35 to 2.79; p <0.001) after adjustment but was not associated with in-hospital mortality (OR 1.05, 95{\%} CI 0.79 to 1.40; p = 0.747). In conclusion, in patients with NSTE-ACS who underwent PCI, women were at greater risk than men for in-hospital complications, especially in bleeding complications.",
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AU - Kadota, Kazushige

AU - Nakamura, Masato

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