Comparison of oxidative stress markers in type 2 diabetes: Basal bolus therapy versus twice daily premixed insulin analogs

Masaki Sakamoto; Gaku Inoue; Kaoru Tsuyusaki; Kensuke Usui; Miwako Watanabe; Junichiro Irie; Koichiro Atsuda; Satoru Yamada

doi:10.2169/internalmedicine.49.2725

Comparison of oxidative stress markers in type 2 diabetes: Basal bolus therapy versus twice daily premixed insulin analogs

Masaki Sakamoto, Gaku Inoue, Kaoru Tsuyusaki, Kensuke Usui, Miwako Watanabe, Junichiro Irie, Koichiro Atsuda, Satoru Yamada

Department of Internal Medicine (Nephrology, Endocrinology and Metabolism)

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Aims: Several studies have shown that twice-daily injection of premixed insulin analog (MIX) therapy achieves glycemic control equivalent to that with basal-bolus (BB) therapy. However, glycemic fluctuations that lead to oxidative stress may be associated with the risk of diabetic complications. Therefore, in this study, we compared oxidative stress markers between MIX therapy and BB therapy. Methods: In this cross-sectional study, we recruited a total of 37 patients (17 patients in the BB group and 20 patients in the MIX group) and compared urinary 8-isoprostane and urinary 8-hydroxydeoxyguanosine (8-OHdG) levels. Results: There were no significant differences in urinary 8-isoprostane (BB vs MIX: 199±92 pg/mg Cr vs 266±107 pg/mg Cr) or urinary 8-OHdG (4.7±1.6 ng/mg Cr vs 5.4±1.9 ng/mg Cr, respectively). Conclusion: These results suggest that MIX is equivalent to BB in terms of glycemic fluctuations and oxidative stress.

Original language	English
Pages (from-to)	355-359
Number of pages	5
Journal	Internal Medicine
Volume	49
Issue number	5
DOIs	https://doi.org/10.2169/internalmedicine.49.2725
Publication status	Published - 2010

Keywords

Diabetes 1
Insulin therapy
Oxidative stress

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.49.2725

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title = "Comparison of oxidative stress markers in type 2 diabetes: Basal bolus therapy versus twice daily premixed insulin analogs",

abstract = "Aims: Several studies have shown that twice-daily injection of premixed insulin analog (MIX) therapy achieves glycemic control equivalent to that with basal-bolus (BB) therapy. However, glycemic fluctuations that lead to oxidative stress may be associated with the risk of diabetic complications. Therefore, in this study, we compared oxidative stress markers between MIX therapy and BB therapy. Methods: In this cross-sectional study, we recruited a total of 37 patients (17 patients in the BB group and 20 patients in the MIX group) and compared urinary 8-isoprostane and urinary 8-hydroxydeoxyguanosine (8-OHdG) levels. Results: There were no significant differences in urinary 8-isoprostane (BB vs MIX: 199±92 pg/mg Cr vs 266±107 pg/mg Cr) or urinary 8-OHdG (4.7±1.6 ng/mg Cr vs 5.4±1.9 ng/mg Cr, respectively). Conclusion: These results suggest that MIX is equivalent to BB in terms of glycemic fluctuations and oxidative stress.",

keywords = "Diabetes 1, Insulin therapy, Oxidative stress",

author = "Masaki Sakamoto and Gaku Inoue and Kaoru Tsuyusaki and Kensuke Usui and Miwako Watanabe and Junichiro Irie and Koichiro Atsuda and Satoru Yamada",

year = "2010",

doi = "10.2169/internalmedicine.49.2725",

language = "English",

volume = "49",

pages = "355--359",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

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TY - JOUR

T1 - Comparison of oxidative stress markers in type 2 diabetes

T2 - Basal bolus therapy versus twice daily premixed insulin analogs

AU - Sakamoto, Masaki

AU - Inoue, Gaku

AU - Tsuyusaki, Kaoru

AU - Usui, Kensuke

AU - Watanabe, Miwako

AU - Irie, Junichiro

AU - Atsuda, Koichiro

AU - Yamada, Satoru

PY - 2010

Y1 - 2010

N2 - Aims: Several studies have shown that twice-daily injection of premixed insulin analog (MIX) therapy achieves glycemic control equivalent to that with basal-bolus (BB) therapy. However, glycemic fluctuations that lead to oxidative stress may be associated with the risk of diabetic complications. Therefore, in this study, we compared oxidative stress markers between MIX therapy and BB therapy. Methods: In this cross-sectional study, we recruited a total of 37 patients (17 patients in the BB group and 20 patients in the MIX group) and compared urinary 8-isoprostane and urinary 8-hydroxydeoxyguanosine (8-OHdG) levels. Results: There were no significant differences in urinary 8-isoprostane (BB vs MIX: 199±92 pg/mg Cr vs 266±107 pg/mg Cr) or urinary 8-OHdG (4.7±1.6 ng/mg Cr vs 5.4±1.9 ng/mg Cr, respectively). Conclusion: These results suggest that MIX is equivalent to BB in terms of glycemic fluctuations and oxidative stress.

AB - Aims: Several studies have shown that twice-daily injection of premixed insulin analog (MIX) therapy achieves glycemic control equivalent to that with basal-bolus (BB) therapy. However, glycemic fluctuations that lead to oxidative stress may be associated with the risk of diabetic complications. Therefore, in this study, we compared oxidative stress markers between MIX therapy and BB therapy. Methods: In this cross-sectional study, we recruited a total of 37 patients (17 patients in the BB group and 20 patients in the MIX group) and compared urinary 8-isoprostane and urinary 8-hydroxydeoxyguanosine (8-OHdG) levels. Results: There were no significant differences in urinary 8-isoprostane (BB vs MIX: 199±92 pg/mg Cr vs 266±107 pg/mg Cr) or urinary 8-OHdG (4.7±1.6 ng/mg Cr vs 5.4±1.9 ng/mg Cr, respectively). Conclusion: These results suggest that MIX is equivalent to BB in terms of glycemic fluctuations and oxidative stress.

KW - Diabetes 1

KW - Insulin therapy

KW - Oxidative stress

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Comparison of oxidative stress markers in type 2 diabetes: Basal bolus therapy versus twice daily premixed insulin analogs

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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