Abstract
Prevention of the atrophy of denervated muscles is essential for a good outcome in facial contouring and oral reconstruction. In this study, we compared the effectiveness of end-to-end and end-to-side neurorrhaphy of the motor nerve, and end-to-end neurorrhaphy of the sensory nerve, all of which are frequently used in such reconstruction for the prevention of muscle atrophy. Wistar rats were divided into four groups: group 1, motor nerve division of semi-membranosus without repair; group 2, motor nerve division and end-to-end coaptation to the saphenous nerve; group 3, motor nerve division and end-to-side coaptation to the sciatic nerve; and group 4, motor nerve division and end-to-end repair. Measurement of semi-membranosus volume, histological evaluation and staining of neuromuscular junctions that were carried out 3 months postoperatively revealed that muscle volume preservation was larger in groups 3 and 4 than in the other two groups (p < 0.05), but slightly superior in group 4 (p < 0.05). There was no statistical difference between groups 2 and 1; histologically, muscle architecture was better preserved in group 2 than in group 1; reactivation of the neuromuscular junctions was observed in all except group 1. End-to-side repair of motor nerves is one of the better options for the preservation of muscle volume when end-to-end nerve repair is not indicated. Sensory protection may also provide some advantages in the preservation of muscle volume.
| Original language | English |
|---|---|
| Pages (from-to) | 943-949 |
| Number of pages | 7 |
| Journal | Journal of Plastic, Reconstructive and Aesthetic Surgery |
| Volume | 65 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2012 Jul |
| Externally published | Yes |
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Keywords
- End-to-end neurorrhaphy
- End-to-side neurorrhaphy
- Reinnervation
- Sensory protection
ASJC Scopus subject areas
- Surgery
Cite this
Comparison of reinnervation for preservation of denervated muscle volume with motor and sensory nerve : An experimental study. / Omori, Makoto; Sakakibara, Shunsuke; Hashikawa, Kazunobu; Terashi, Hiroto; Tahara, Shinya; Sugiyama, Daisuke.
In: Journal of Plastic, Reconstructive and Aesthetic Surgery, Vol. 65, No. 7, 07.2012, p. 943-949.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of reinnervation for preservation of denervated muscle volume with motor and sensory nerve
T2 - An experimental study
AU - Omori, Makoto
AU - Sakakibara, Shunsuke
AU - Hashikawa, Kazunobu
AU - Terashi, Hiroto
AU - Tahara, Shinya
AU - Sugiyama, Daisuke
PY - 2012/7
Y1 - 2012/7
N2 - Prevention of the atrophy of denervated muscles is essential for a good outcome in facial contouring and oral reconstruction. In this study, we compared the effectiveness of end-to-end and end-to-side neurorrhaphy of the motor nerve, and end-to-end neurorrhaphy of the sensory nerve, all of which are frequently used in such reconstruction for the prevention of muscle atrophy. Wistar rats were divided into four groups: group 1, motor nerve division of semi-membranosus without repair; group 2, motor nerve division and end-to-end coaptation to the saphenous nerve; group 3, motor nerve division and end-to-side coaptation to the sciatic nerve; and group 4, motor nerve division and end-to-end repair. Measurement of semi-membranosus volume, histological evaluation and staining of neuromuscular junctions that were carried out 3 months postoperatively revealed that muscle volume preservation was larger in groups 3 and 4 than in the other two groups (p < 0.05), but slightly superior in group 4 (p < 0.05). There was no statistical difference between groups 2 and 1; histologically, muscle architecture was better preserved in group 2 than in group 1; reactivation of the neuromuscular junctions was observed in all except group 1. End-to-side repair of motor nerves is one of the better options for the preservation of muscle volume when end-to-end nerve repair is not indicated. Sensory protection may also provide some advantages in the preservation of muscle volume.
AB - Prevention of the atrophy of denervated muscles is essential for a good outcome in facial contouring and oral reconstruction. In this study, we compared the effectiveness of end-to-end and end-to-side neurorrhaphy of the motor nerve, and end-to-end neurorrhaphy of the sensory nerve, all of which are frequently used in such reconstruction for the prevention of muscle atrophy. Wistar rats were divided into four groups: group 1, motor nerve division of semi-membranosus without repair; group 2, motor nerve division and end-to-end coaptation to the saphenous nerve; group 3, motor nerve division and end-to-side coaptation to the sciatic nerve; and group 4, motor nerve division and end-to-end repair. Measurement of semi-membranosus volume, histological evaluation and staining of neuromuscular junctions that were carried out 3 months postoperatively revealed that muscle volume preservation was larger in groups 3 and 4 than in the other two groups (p < 0.05), but slightly superior in group 4 (p < 0.05). There was no statistical difference between groups 2 and 1; histologically, muscle architecture was better preserved in group 2 than in group 1; reactivation of the neuromuscular junctions was observed in all except group 1. End-to-side repair of motor nerves is one of the better options for the preservation of muscle volume when end-to-end nerve repair is not indicated. Sensory protection may also provide some advantages in the preservation of muscle volume.
KW - End-to-end neurorrhaphy
KW - End-to-side neurorrhaphy
KW - Reinnervation
KW - Sensory protection
UR - http://www.scopus.com/inward/record.url?scp=84862523987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862523987&partnerID=8YFLogxK
U2 - 10.1016/j.bjps.2012.01.018
DO - 10.1016/j.bjps.2012.01.018
M3 - Article
C2 - 22366538
AN - SCOPUS:84862523987
VL - 65
SP - 943
EP - 949
JO - Journal of Plastic, Reconstructive and Aesthetic Surgery
JF - Journal of Plastic, Reconstructive and Aesthetic Surgery
SN - 1748-6815
IS - 7
ER -