Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser doppler flowmetry

Masashi Kusano, Haruka Nakayama, Hiroyuki Takuwa, Kazuto Masamoto, Iwao Kanno, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cerebral blood flow (CBF) change of mice during whisker stimulation is measured by laser speckle flowgraphy (LSFG) and laser Doppler flowmetry (LDF). Laser speckle flowgraphy (LSFG) has been used to obtain the two-dimensional distribution of the blood flow in tissue as well as scanning laser Doppler flowmetry (LDF). There are several parameters of LSFG to obtain the blood flow maps and the distribution change of blood flow. In this study, we calculate four parameters from the speckle pattern to measure CBF in awake mice. The temporal resolution of LSFG is likely to be less than that of LDF. The temporal changes in CBF obtained from the four parameters calculated from the speckle pattern detected by a common CCD camera are compared with those measured by LDF. The time courses of CBF change measured by LSFG highly correlate with those by LDF. The results indicate that the temporal response of LSFG is sufficient to measure CBF change evoked by brain activations.

Original languageEnglish
Title of host publicationOptics InfoBase Conference Papers
Publication statusPublished - 2011
EventEuropean Conference on Biomedical Optics, ECBO 2011 - Munich, Germany
Duration: 2011 May 222011 May 26

Other

OtherEuropean Conference on Biomedical Optics, ECBO 2011
CountryGermany
CityMunich
Period11/5/2211/5/26

Fingerprint

blood flow
Speckle
Blood
Lasers
lasers
speckle patterns
mice
CCD cameras
temporal resolution
stimulation
brain
Brain
Chemical activation
activation
Tissue
Scanning
scanning

Keywords

  • Cerebral blood flow
  • Laser doppler flowmetry
  • Laser speckle flowgraphy
  • Optical imaging

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

Cite this

Kusano, M., Nakayama, H., Takuwa, H., Masamoto, K., Kanno, I., & Okada, E. (2011). Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser doppler flowmetry. In Optics InfoBase Conference Papers [80880E]

Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser doppler flowmetry. / Kusano, Masashi; Nakayama, Haruka; Takuwa, Hiroyuki; Masamoto, Kazuto; Kanno, Iwao; Okada, Eiji.

Optics InfoBase Conference Papers. 2011. 80880E.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kusano, M, Nakayama, H, Takuwa, H, Masamoto, K, Kanno, I & Okada, E 2011, Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser doppler flowmetry. in Optics InfoBase Conference Papers., 80880E, European Conference on Biomedical Optics, ECBO 2011, Munich, Germany, 11/5/22.
Kusano M, Nakayama H, Takuwa H, Masamoto K, Kanno I, Okada E. Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser doppler flowmetry. In Optics InfoBase Conference Papers. 2011. 80880E
Kusano, Masashi ; Nakayama, Haruka ; Takuwa, Hiroyuki ; Masamoto, Kazuto ; Kanno, Iwao ; Okada, Eiji. / Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser doppler flowmetry. Optics InfoBase Conference Papers. 2011.
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