Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser Doppler flowmetry

Masashi Kusano, Haruka Nakayama, Hiroyuki Takuwa, Kazuto Masamoto, Iwao Kanno, Eiji Okada

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Cerebral blood flow (CBF) change of mice during whisker stimulation is measured by laser speckle flowgraphy (LSFG) and laser Doppler flowmetry (LDF). Laser speckle flowgraphy (LSFG) has been used to obtain the two-dimensional distribution of the blood flow in tissue as well as scanning laser Doppler flowmetry (LDF). There are several parameters of LSFG to obtain the blood flow maps and the distribution change of blood flow. In this study, we calculate four parameters from the speckle pattern to measure CBF in awake mice. The temporal resolution of LSFG is likely to be less than that of LDF. The temporal changes in CBF obtained from the four parameters calculated from the speckle pattern detected by a common CCD camera are compared with those measured by LDF. The time courses of CBF change measured by LSFG highly correlate with those by LDF. The results indicate that the temporal response of LSFG is sufficient to measure CBF change evoked by brain activations.

    Original languageEnglish
    Title of host publicationDiffuse Optical Imaging III
    DOIs
    Publication statusPublished - 2011 Jul 28
    EventDiffuse Optical Imaging III - Munich, Germany
    Duration: 2011 May 222011 May 24

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume8088
    ISSN (Print)1605-7422

    Other

    OtherDiffuse Optical Imaging III
    CountryGermany
    CityMunich
    Period11/5/2211/5/24

    Keywords

    • cerebral blood flow
    • laser Doppler flowmetry
    • laser speckle flowgraphy
    • optical Imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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  • Cite this

    Kusano, M., Nakayama, H., Takuwa, H., Masamoto, K., Kanno, I., & Okada, E. (2011). Comparison of temporal response to cerebral blood flow measured by laser speckle flowgraphy and laser Doppler flowmetry. In Diffuse Optical Imaging III [80880E] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8088). https://doi.org/10.1117/12.889787